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001-es BibID:BIBFORM032944
035-os BibID:(Scopus)84856275918 (WOS)000298887100008
Első szerző:Budincevic, Hrvoje
Cím:Translational challenges of neuroprotection strategy in ischemic stroke / Hrvoje Budincevic, Ivan Bielen, László Csiba
Dátum:2011
Megjegyzések:Neuroprotection is a therapeutic strategy that attempts to save neurons from irreversible injury by modifying the effects of the ischemic cascade or facilitating reperfusion. Although numerous agents have shown neuroprotective effect in preclinical trials, their translation to clinical trials failed to show any meaningful effect. The Stroke Therapy Academic Industry Roundtable (STAIR) guidelines were made for performing research on neuroprotective agents in pre-clinical and clinical trials. Although the STAIR guidelines have been available for more than ten years, we still do not have any adequate neuroprotective agents. Reasons for unsuccessful translation from preclinical to clinical research can be considered along stages of drug development: 1) preclinical, 2) transitional and 3) clinical. By extending the therapeutic window for application of intravenous thrombolysis in acute stroke patients to 4.5 hours, as well as increasing the use intra-arterial thrombolysis and development of mechanical devices for thrombectomy in 6 hour period we may be able to achieve some degree of neuroprotection in acute stroke. Future therapy is likely to add to the current thrombolytic therapy with potential neuroprotective drugs or procedures.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
egyetemen (Magyarországon) készült közlemény
Megjelenés:Translational Neuroscience. - 2 : 4 (2011), p. 344-350. -
További szerzők:Bielen, Ivan Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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2.

001-es BibID:BIBFORM087867
035-os BibID:(Scopus)85091004594 (WOS)000565252800001
Első szerző:Fülesdi Béla (aneszteziológus)
Cím:Correlation between calcium, water contents and ultrasonographic appearance of atherosclerotic lesions of carotid artery lesions / Béla Fülesdi, Szabolcs Farkas, Zoltán Gyöngyösi, Péter Siró, Dániel Bereczki, József Bacsó, László Csiba
Dátum:2020
ISSN:2081-3856 2081-6936
Megjegyzések:Background We tested the hypothesis whether there is a correlation between the echogenicity and calcium and water contents of carotid plaques. Patients and methods Ninety carotid befurcations from 45 deceased patients were removed during autopsy. Thirty-four plaques were categorized as homogenous echolucent (HEL), homogenous echogenic (HEG) and heterogenous (HE) plaques based on premortem B-mode image. Water content was expressed in % of wet weight. Ca was determined by proton-induced X-ray emission and expressed in ppm. Relative optical density of the B-mode images was analyzed offline using a computer program. Results HEL plaques had lower Ca content (medians and IQRs: 6,145 [4,465?6,536?ppm]) compared to HEG (74,100 [15,300?1,44,500?ppm]), P ? 0.001). HE plaques showed an intermediate calcium content (7,310 [4,840?9,920?ppm]) that was statistically not different from echolucent plaques. Water content of HEG plaques was statistically not different from HEL and HE (HEG:53.5 [35.5?64%], HEL: 73.5 [69.7?78.5%], HE: 70.6 [67.4?73.9%]). HEG plaques had the highest relative optical densities (196 [188?217%]). HEL and HE had similar relative optical densities (HEL: 176 [164?187%], HE: 164 [144?188%], respectively). A significant positive correlation was found between the Ca content and relative optical density of plaques. Conclusions Echogenicity of carotid plaques increases along with their calcium content. Water content may be an important factor in differentiation of different plaques.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ca and water contents
carotid plaque
B-mode ultrasound
ultrasonic tissue characterisation
Megjelenés:Translational Neuroscience. - 11 : 1 (2020), p. 269-276. -
További szerzők:Farkas Szabolcs (1983-) (orvos) Gyöngyösi Zoltán (1977-) (aneszteziológus) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Bereczki Dániel (1960-) (neurológus) Bacsó József Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:2017-1.2.1-NKP-2017-00002
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM105018
035-os BibID:(WOS)000879996500001 (Scopus)85142129652
Első szerző:Orosz László (sebész)
Cím:Assessment of malformations, variations and diameters of vessels forming the circle of Willis : An autopsy study in a non-cerebrovascular cohort / Orosz László, Gyöngyösi Zoltán, Susán Zsolt, Siró Péter, Hoksbergen Arjan Willem, Csiba László, Fülesdi Béla
Dátum:2022
ISSN:2081-3856 2081-6936
Megjegyzések:Background a purpose The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed to assess CoW variations and vessel diameters in a Central European cohort. Subjects and methods CoWs were removed during routine autopsy. The morphological pattern of the circles was recorded. The prepared circles were then put between two glass plates and tightly compressed. The length of the vessels and half of the circumference were measured under a light microscope enabling measurement with an approximation of 0.1?mm. Vessel diameters were calculated from vessel circumference. Results A total of 110 circles were analysed. Incomplete circles (missing one or two segments of CoW) were found in 25 cases (22.7%). Any forms of anatomical variations were detected in 14 cases (12.7%). When applying the <1?mm diameter threshold for analysis, 36 anterior communicating arteries (32.7%), 53 right posterior communicating arteries (48.2%), 73 left posterior communicating arteries (66.4%) and 18 posterior communicating arteries (16.3%) on both the sides were considered hypoplastic. Conclusions In patients without stroke in their history, complete CoW may be present in >60% of the cases. Our diameter data may serve as reference values for the Central-European population.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Translational Neuroscience. - 13 : 1 (2022), p. 398-406. -
További szerzők:Gyöngyösi Zoltán (1977-) (aneszteziológus) Susán Zsolt (1983-) (sebész) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Hoksbergen, Arjan W. J. Csiba László (1952-) (neurológus, pszichiáter) Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:Szerző által megadott URL
DOI
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