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1.

001-es BibID:BIBFORM029870
035-os BibID:PMID:22017293
Első szerző:Auriel, Eitan
Cím:Leukoaraiosis is associated with arterial wall thickness : a quantitative analysis / Auriel Eitan, Csiba Laszlo, Berenyi Ervin, Varkonyi Ildiko, Mehes Gabor, Kardos Laszlo, Karni Arnon, Bornstein Natan M.
Dátum:2012
ISSN:0919-6544
Megjegyzések:Leukoaraiosis refers to an age-related, abnormal appearance of the brain white matter on neuroimaging. The association between leukoaraiosis and cerebrovascular disease suggests that ischemia may be an important contributing factor; however, the pathogenesis of the condition remains controversial. We hypothesized that physical abnormalities of blood vessels might be culpable and compared the external and internal measurements of blood vessel walls between brains that demonstrated leukoaraiosis on imaging and normal control brains. Fourteen brains of individuals who had been diagnosed as having severe leukoaraiosis and five non-leukoaraiosis control brains were studied. Arterial cross-sections were evaluated by length measurements with an image analysis device. Arterial wall thickness and the ratio of the outer and inner diameters of the vessel were measured. We measured a total of 108 vessels in the leukoaraiosis group and 95 vessels in the control group. The vessel walls of the leukoaraiosis patients were an average of 5.5 mikrom thicker than the walls of control vessels of the same inside diameter (P = 0.0000, 95% CI 3.01-8.08) and an average of 2.3 mikrom thicker than walls of control vessels of the same outside diameter (P = 0.016, 95% CI 0.48-4.17). Our data provide evidence that leukoaraiosis is associated with vessel wall thickening in an additive fashion and indicate that structural vascular abnormalities are associated with leukoaraiosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuropathology. - 32 : 3 (2012), p. 227-233. -
További szerzők:Csiba László (1952-) (neurológus, pszichiáter) Berényi Ervin (1964-) (radiológus) Várkonyi Ildikó (szakorvos jelölt) Méhes Gábor (1966-) (patológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Karni, Arnon Bornstein, Natan M.
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2.

001-es BibID:BIBFORM016921
035-os BibID:(WoS)000284961100007 (Scopus)78650048739
Első szerző:Auriel, Eitan
Cím:Clinical, radiological and pathological correlates of leukoaraiosis / Auriel, E., Bornstein, N. M., Berenyi, E., Varkonyi, I., Mehes, G., Majtenyi, K., Szepesi, R., Goldberg, I., Lampe, R., Csiba, L.
Dátum:2011
ISSN:0001-6314
Megjegyzések:Introduction - Leukoaraiosis is characterized by an abnormal appearanceof the brain white matter on imaging. Its pathogenesis is still amatter of investigation. The purpose of this study was to investigatethe radiological, clinical and pathological correlates ofleukoaraiosis. Methods - The study population consisted of 93 deceasedpatients. The pre-mortem T2W magnetic resonance images were evaluatedfor the presence and grading of leukoaraiosis. The clinical andpathological characteristics based on the clinical charts and autopsyreports were evaluated. Tissue specimens of the blocks of 19 brainsthat demonstrated severe leukoaraiosis and those of five control brainswere excised and stained. Results - The variables found to besignificantly associated with leukoaraiosis were age and a clinicalhistory of Parkinson's disease. Other risk factors and pathologicalmarkers of atherosclerosis were not significantly correlated withleukoaraiosis. No significant difference was found between the scoringof the myelin integrity, glial fibrillary acidic protein, cluster ofdifferentiation 68 and smooth muscle actin. There was a significantdifference with respect to thickening of vessels walls. Conclusions - Our pathological results indicate that structural vascularabnormalities characterized by vessel wall thickening are associatedwith leukoaraiosis, supporting the assertion that vascular changes andischemia generate leukoaraiosis. The relations between parkinsonism andleukoaraiosis may be explicable through vascular effects on thecircuitry of the basal ganglia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Acta Neurologica Scandinavica. - 123 : 1 (2011), p. 41-47. -
További szerzők:Bornstein, Natan M. Berényi Ervin (1964-) (radiológus) Várkonyi Ildikó (szakorvos jelölt) Méhes Gábor (1966-) (patológus) Majtényi K. Szepesi Rita (1975-) (neurológus) Goldberg, Isaac Lampé Rudolf (1983-) (szülész-nőgyógyász) Csiba László (1952-) (neurológus, pszichiáter)
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3.

001-es BibID:BIBFORM106780
Első szerző:Baracchini, Claudio
Cím:Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic : an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics / Baracchini C., Pieroni A., Kneihsl M., Azevedo E., Diomedi M., Pascazio L., Wojczal J., Lucas C., Bartels E., Bornstein N. M., Csiba L., Valdueza J., Tsivgoulis G., Malojcic B.
Dátum:2020
ISSN:1351-5101
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Neurology. - 27 : 9 (2020), p. 1776-1780. -
További szerzők:Pieroni, Alessio Kneihsl, M. Azevedo, Elsa Diomedi, M. Pascazio, L. Wojczal, J. Lucas, Christina Bartels, Eva Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Valdueza, José M. Tsivgoulis, Georgios Malojcic, Branko
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4.

001-es BibID:BIBFORM036709
Első szerző:Baracchini, Claudio
Cím:CCSVI and MS : a statement from the European Society of neurosonology and cerebral hemodynamics / Baracchini Claudio, Valdueza José M., Del Sette Massimo, Baltgaile Galina, Bartels Eva, Bornstein Natan M., Klingelhoefer Juergen, Molina Carlos, Niederkorn Kurt, Siebler Mario, Sturzenegger Matthias, Ringelstein Bernd E., Russell David, Csiba Laszlo
Dátum:2012
ISSN:0340-5354
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurology. - 259 : 12 (2012), p. 2585-2589. -
További szerzők:Valdueza, José M. Del Sette, Massimo Baltgaile, Galina Bartels, Eva Bornstein, Natan M. Klingelhoefer, Juergen Molina, Carlos Niederkorn, Kurt Siebler, Mario Sturzenegger, Matthias Ringelstein, E. Bernd Russell, David Csiba László (1952-) (neurológus, pszichiáter)
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5.

001-es BibID:BIBFORM010623
Első szerző:Boms, Neta
Cím:Effect of smoking cessation on visually evoked cerebral blood flow response in healthy volunteers / Neta Boms, Yaniv Yonai, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:1018-1172 (Print)
Megjegyzések:In our previous study, impaired visually evoked flow velocity response was demonstrated in young chronic smokers. Our aim was to study whether impaired cerebrovascular reactivity is reversible 6?18 months after smoking cessation. Methods: Flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries in 15 smokers, 15 former smokers and 15 nonsmokers. The stimulation protocol consisted of 10 cycles with a resting phase of 20 s (baseline) and a stimulating phase of 40 s for each cycle. Relative changes of flow velocity were expressed in relation to baseline. Breath holding index, visual evoked potential and intima-media thickness were also examined. Results: Repeated measures ANOVA revealed marked difference in the flow velocity time courses between the 3 groups (p ! 0.01). The flow response was significantly worse in former smokers than in nonsmokers (p ! 0.002), however, no significant difference was found between former and current smokers (p = 0.0556). Conclusion: This is the first transcranial Doppler study demonstrating long-term impairment of visually evoked cerebrovascular response af-ter smoking cessation. These findings indicate that the impairment of neurovascular coupling caused by smoking is due to structural changes of the vessels, rather than acute effect of smoking.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Transcranial Doppler
Hemodynamics
Vasoreactivity
Neurovascular coupling
Visual stimulation
Cerebral blood flow
Smoking
Megjelenés:Journal of Vascular Research. - 47 : 3 (2010), p. 214-220. -
További szerzők:Yonai, Yaniv Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:K 68864
OTKA
ETT 260/2009
EGYÉB
ETT 197-05/2010
EGYÉB
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6.

001-es BibID:BIBFORM050856
Első szerző:Czuriga-Kovács Katalin Réka (neurológus)
Cím:Silent brain infarction : a review of recent observations / Katalin Réka Kovács, Dániel Czuriga, Dániel Bereczki, Natan M. Bornstein, László Csiba
Dátum:2013
ISSN:1747-4930 1747-4949
Megjegyzések:Silent brain infarction (SBI) is a cerebral ischemic event evident on brain imaging without any clinical symptom. SBI is often detected in apparently healthy, elderly people and in different selected patient groups as well. Lately, several studies were carried out in order to identify the clinical conditions leading to SBI. A large number of clinical and paraclinical parameters were found to increase SBI prevalence, and the continuously growing list of risk factors revealed, that the majority of them are similar to those related to stroke. Accordingly, some consider SBI the preclinical stage of clinically overt stroke. This point of view emphasizes the early recognition and management of SBI related risk factors, and a great need for comparative studies, which could elicit the most sensitive indicators of the increased SBI risk, especially the ones that could be cost-effectively screened in the large populations as well.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Silent brain infarction
Cerebral ischemia
Stroke
Risk factors
Megjelenés:International Journal of Stroke. - 8 : 5 (2013), p. 334-347. -
További szerzők:Czuriga Dániel (1982-) (kardiológus) Bereczki Dániel (1960-) (neurológus) Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter)
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7.

001-es BibID:BIBFORM090992
035-os BibID:(cikkazonosító)e0217472 (WOS)000484927300005 (Scopus)85069268954
Első szerző:Khurana, Dheeraj
Cím:Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke / Khurana Dheeraj, Kaul Subhash, Schneider Dietmar, Csanyi Attila, Adam Ilona, Ichaporia Nasli R., Griewing Bernd, Csiba Laszlo, Valikovics Attila, Puri Vinod, Diener Hans Christoph, Schwab Stefan, Hetzel Andreas, Bornstein Natan, ImpACT-1 Study Group
Dátum:2019
ISSN:1932-6203
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 14 : 7 (2019), p. 1-14. -
További szerzők:Kaul, Subhash Schneider, Dietmar Csányi Attila Ádám Ilona Ichaporia, Nasli R. Griewing, Bernd Csiba László (1952-) (neurológus, pszichiáter) Valikovics Attila Puri, Vinod Diener, Hans-Christoph Schwab, Stefan Hetzel, Andreas Bornstein, Natan M. ImpACT-1 Study Group
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8.

001-es BibID:BIBFORM007352
Első szerző:Oláh László (neurológus)
Cím:Visually evoked cerebral vasomotor response in smoking and non-smoking young adults, investigated byfunctional transcanial doppler / László Oláh, Yaron Raiter, Claudia Candale, Sándor Molnár, Bernhard Rosengarten, Natan M. Bornstein, László Csiba
Dátum:2008
Megjegyzések:Smoking has been known to cause endothelial dysfunction and is an important risk factor for ischemic stroke. In our study we investigated whether chronic cigarette smoking affects the cerebral blood flow velocity response to a physiological, visual stimulus. By using a visual cortex stimulation paradigm, the flow velocity response in the posterior cerebral arteries (PCA) was measured bilaterally, in 32 young healthy adults (16 smokers, 16 non-smokers). The stimulation protocol consisted of 10 cycles with a resting phase of 20 seconds and a stimulating phase of 40 seconds for each cycle. Besides functional transcranial Doppler (TCD), laboratory tests and measurement of intima-media-thickness (IMT) were also performed. Repeated measure ANOVA was used to detect differences in visually evoked relative flow velocity time courses between smokers and non-smokers. Repeated measure ANOVA revealed marked difference in the peak systolic flow velocity time courses between smokers and non-smokers (p<0.001). Maximum percent change of visually evoked flow velocity after visual stimulation was 19?4% and 30?3% in smokers and non-smokers, respectively (p<0.0001). IMT values did not indicate atherosclerosis in young smokers. Infectious disease and hyperlipidaemia were also ruled out by measurement of sensitive Creactive protein and serum lipids. This is the first functional TCD study demonstrating impaired visually evoked flow velocity response caused by chronic cigarette smoking in otherwise healthy, young subjects. The impaired cerebral vasodilatory mechanism together with atherosclerosis may influence stroke occurrence and outcome in chronic smokers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nicotine Tobacco Research. - 10 : 2 (2008), p. 353-358. -
További szerzők:Raiter, Yaron Candale, Claudia Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:elektronikus változat
DOI
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9.

001-es BibID:BIBFORM013718
Első szerző:Yonai, Yaniv
Cím:Acetazolamide-induced vasodilation does not inhibit the visually evoked flow response / Yaniv Yonai, Neta Boms, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:0271-678X
Megjegyzések:Different methods are used to assess the vasodilator ability of cerebral blood vessels; however, the exact mechanism of cerebral vasodilation, induced by different stimuli, is not entirely known. Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation. Therefore, visually evoked flow parameters were examined by transcranial Doppler in ten healthy subjects before and after AZ administration. Pulsatility index and peak systolic flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries before and after intravenous administration of 15 mg/kg AZ. Repeated-measures ANOVA did not show significant group main effect between the visually evoked relative flow velocity time courses before and after AZ provocation (P=0.43). Visual stimulation induced significant increase of relative flow velocity and decrease of pulsatility index not only before but also at the maximal effect of AZ. These results suggest that maximal cerebral vasodilation cannot be determined by the clinically accepted dose of AZ (15 mg/kg) and prove that neurovascular coupling remains preserved despite AZ-induced vasodilation. Our observation indicates independent regulation of vasodilation during neurovascular coupling, allowing the adaptation of cerebral blood flow according to neuronal activity even if other processes require significant vasodilation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Cerebral Blood Flow and Metabolism. - 30 : 3 (2010), p. 516-521. -
További szerzők:Boms, Neta Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:0271-678x/10
Egyéb
ETT 260/2009
Egyéb
ETT 197-05/2010
Egyéb
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