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001-es BibID:	BIBFORM007505
Első szerző:	Csiba László (neurológus, pszichiáter)
Cím:	A topographic quantitative method for measuring brain tissue pH under physiological and pathophysiological conditions / Csiba L., Paschen W., Hossmann K. A.
Dátum:	1983
Megjegyzések:	A technique was developed for the quantitative regional assessment of brain pH by a modification of the umbelliferone method. Twenty micron thick sections were brought into contact with umbelliferone-soaked paper strips and the fluorescence (450 nm) following excitation at 370 nm and 340 nm was recorded photographically. The 340 nm excitation image was subtracted from 370 nm picture, using a computerized image-processing system. Regional pH values were measured in rats and cats under normal and ischemic conditions
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Brain Research. - 289 : 1-2 (1983), p. 334-337. -
További szerzők:	Paschen, Wulf Hossmann, Konstantin-Alexander
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001-es BibID:	BIBFORM007559
Első szerző:	Hossmann, Konstantin-Alexander
Cím:	Regional pH and electrolyte homeostasis of cat brain after prolonged ischemia / Hossmann K. A., Ophoff B. G., Csiba L., Paschen W.
Dátum:	1988
Megjegyzések:	Following prolonged cerebral ischemia, primary electrophysiological recovery may be followed by secondary deterioration of the recovery process. It has been suggested that the secondary deterioration is caused by "late" cytotoxic brain edema. To test this hypothesis, adult normothermic cats were submitted to 1 h complete cerebral ischemia followed by 3 and 6 h recirculation, respectively. Postischemic recovery of energy metabolism was imaged by ATP-induced bioluminescence, and regional tissue pH and electrolyte content was measured in regions with and without metabolic recovery. In areas with postischemic restitution of metabolic activity, sodium gradually rose from 338 +/- 17 to 488 +/- 28 mumol/g protein and calcium from 8.81 +/- 0.35 to 18.24 +/- 0.97 mumol/g protein. Tissue potassium content decreased from 761 +/- 12 to 676 +/- 19 mumol/g protein and magnesium from 46.8 +/- 0.8 to 36.3 +/- 1.1 mumol/g protein. Tissue pH rose from 7.09 +/- 0.04 to 7.31 +/- 0.13 and 7.26 +/- 0.17 after 3 and 6 h recirculation, respectively. In areas without metabolic recovery, electrolyte disturbances were even more pronounced and pH--after transient alkalization--fell to 6.82 +/- 0.12. These data demonstrate that during the later phase of postischemic recirculation, progressive disturbances of electrolyte homeostasis create a preedematous situation that has to be considered for preventing delayed postischemic complications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neurochemical Pathology. - 9 (1988), p. 127-137. -
További szerzők:	Ophoff, B. G. Csiba László (1952-) (neurológus, pszichiáter) Paschen, Wulf
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001-es BibID:	BIBFORM007523
Első szerző:	Hossmann, Konstantin-Alexander
Cím:	Multiparametric imaging of blood flow and metabolism after middle cerebral artery occlusion in cats / Hossmann K. A., Mies G., Paschen W., Csiba L., Bodsch W., Rapin J. R., Leponcinlafitte M., Takahashi K.
Dátum:	1985
Megjegyzések:	In anesthetized adult cats, acute stroke was produced by transorbital occlusion of the left middle cerebral artery. A battery of imaging techniques was used for simultaneous evaluation of regional blood flow, glucose utilization, protein synthesis, pH, and the regional tissue content of glucose, ATP, and potassium. The electrophysiological impact of stroke was monitored by EEG frequency analysis and recording of somatosensory evoked potentials. Two hours after vascular occlusion, a close correlation existed between the degree of electrophysiological changes and biochemical alterations, in particular with the extent of tissue acidosis, ATP depletion, decrease of tissue potassium content, and suppression of protein synthesis. However, there was only a poor correlation with blood flow and glucose utilization. Both of these exhibited a greatly inhomogeneous pattern with regions of reduced, normal, or increased rates. In areas remote from the infarct, the content of biochemical substrates was normal but blood flow was reduced globally by approximately 50% and glucose utilization by approximately 20%. An anatomically defined regional pattern of cerebral or cerebellar diaschisis was not observed. It is concluded that during the acute phase of stroke, imaging of blood flow and glucose utilization does not provide an accurate estimate of the actual functional or metabolic disturbance. For the clinical evaluation of the development or treatment of stroke, in consequence, alternative noninvasive techniques such as imaging of protein synthesis and/or pH may be more relevant.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cerebral Blood Flow and Metabolism. - 5 (1985), p. 97-107. -
További szerzők:	Mies, Günter Paschen, Wulf Csiba László (1952-) (neurológus, pszichiáter) Bodsch, W. Rapin, J. R. Leponcinlafitte, M. Takahashi, Kentaro
Internet cím:	elektronikus változat DOI
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001-es BibID:	BIBFORM007506
Első szerző:	Hossmann, Konstantin-Alexander
Cím:	Relationship between calcium accumulation and recovery of cat brain after prolonged cerebral ischemia / Hossmann K. A., Paschen W., Csiba L.
Dátum:	1983
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cerebral Blood Flow and Metabolism. - 3 : 3 (1983), p. 346-353. -
További szerzők:	Paschen, Wulf Csiba László (1952-) (neurológus, pszichiáter)
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