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1.
001-es BibID:
BIBFORM046046
Első szerző:
Diener, Hans-Christoph
Cím:
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH) : randomised, double-blind, placebo-controlled trial / Diener Hans-Christoph, Bogousslavsky Julien, Brass Lawrence M, Cimminiello Claudio, Csiba Laszlo, Kaste Markku, Leys Didier, Matias-Guiu Jordi, Rupprecht Hans-Jürgen, the MATCH Investigators
Dátum:
2004
ISSN:
0140-6736
Megjegyzések:
Clopidogrel was superior to aspirin in patients with previous manifestations of atherothrombotic disease in the CAPRIE study and its benefit was amplified in some high-risk subgroups of patients. We aimed to assess whether addition of aspirin to clopidogrel could have a greater benefit than clopidogrel alone in prevention of vascular events with potentially higher bleeding risk. METHODS: We did a randomised, double-blind, placebo-controlled trial to compare aspirin (75 mg/day) with placebo in 7599 high-risk patients with recent ischaemic stroke or transient ischaemic attack and at least one additional vascular risk factor who were already receiving clopidogrel 75 mg/day. Duration of treatment and follow-up was 18 months. The primary endpoint was a composite of ischaemic stroke, myocardial infarction, vascular death, or rehospitalisation for acute ischaemia (including rehospitalisation for transient ischaemic attack, angina pectoris, or worsening of peripheral arterial disease). Analysis was by intention to treat, using logrank test and a Cox's proportional-hazards model. FINDINGS: 596 (15.7%) patients reached the primary endpoint in the group receiving aspirin and clopidogrel compared with 636 (16.7%) in the clopidogrel alone group (relative risk reduction 6.4%, [95% CI -4.6 to 16.3]; absolute risk reduction 1% [-0.6 to 2.7]). Life-threatening bleedings were higher in the group receiving aspirin and clopidogrel versus clopidogrel alone (96 [2.6%] vs 49 [1.3%]; absolute risk increase 1.3% [95% CI 0.6 to 1.9]). Major bleedings were also increased in the group receiving aspirin and clopidogrel but no difference was recorded in mortality. INTERPRETATION: Adding aspirin to clopidogrel in high-risk patients with recent ischaemic stroke or transient ischaemic attack is associated with a non-significant difference in reducing major vascular events. However, the risk of life-threatening or major bleeding is increased by the addition of aspirin.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Lancet. - 364 : 9431 (2004), p. 331-337. -
További szerzők:
Bogousslavsky, Julien
Brass, Lawrence M.
Cimminiello, Claudio
Csiba László (1952-) (neurológus, pszichiáter)
Kaste, Markku
Leys, Didier
Matias-Guiu, Jordi
Rupprecht, Hans-Jürgen
the MATCH Investigators
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM029302
Első szerző:
Diener, Hans-Christoph
Cím:
Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH) : study design and baseline data / Diener, H. C., Bogousslavsky, J., Brass, L. M., Cimminiello, C., Csiba, L., Kaste, M., Leys, D., Matias Guiu, J., Rupprecht, H. J., the MATCH Investigators
Dátum:
2004
ISSN:
1015-9770
Megjegyzések:
The CAPRIE study showed the superiority of clopidogrel over acetylsalicylic acid (ASA) for reducing the combined risk of major atherothrombotic events in patients with recent myocardial infarction (MI), recent ischaemic stroke (IS) or established peripheral arterial disease. The benefit of clopidogrel over ASA is amplified in high-risk patients. Proof of concept for the benefit of clopidogrel in addition to ASA in patients with coronary manifestations of atherothrombosis was provided by the CURE trial. METHODS: MATCH is a randomized, double-blind, placebo-controlled trial that compares clopidogrel and ASA versus clopidogrel alone in high-risk patients with recently symptomatic cerebrovascular disease. Eligible patients have experienced a transient ischaemic attack (TIA) or IS within the last 3 months and have evidence of at least 1 additional risk factor within the last 3 years (prior IS, MI, stable or unstable angina pectoris, diabetes or symptomatic peripheral arterial disease). Patients were randomized to receive ASA 75 mg once daily or placebo, with both groups receiving clopidogrel 75 mg once daily as part of standard therapy. The primary end point is the composite of IS, MI, vascular death and rehospitalization for an acute ischaemic event. The duration of treatment and follow-up is 18 months for each patient. RESULTS: Enrollment was completed in April 2002, with 7,599 patients randomized to receive the study medication. The mean age at randomization was 66 years, and the qualifying event was IS in 78.9% of patients and TIA in 21.1%. The baseline features of the study cohort indicate a population that is at a high risk for atherothrombotic recurrence. CONCLUSION: MATCH is a major ongoing trial that will provide important data on the benefit of clopidogrel and ASA compared with clopidogrel alone for reduction of vascular ischaemic events in patients with recent TIA or IS who are at high risk of atherothrombotic event recurrence.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Cerebrovascular Diseases. - 17 : 2-3 (2004), p. 253-261. -
További szerzők:
Bogousslavsky, Julien
Brass, Lawrence M.
Cimminiello, Claudio
Csiba László (1952-) (neurológus, pszichiáter)
Kaste, Markku
Leys, Didier
Matias-Guiu, Jordi
Rupprecht, Hans-Jürgen
the MATCH Investigators
Internet cím:
DOI
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM090995
035-os BibID:
(WoS)000477012300043 (Scopus)85068808314
Első szerző:
Greving, Jacoba P.
Cím:
Antiplatelet Therapy After Noncardioembolic Stroke : an Individual Patient Data Network Meta-Analysis / Greving Jacoba P., Diener Hans-Christoph, Reitsma Johannes B., Bath Philip M., Csiba László, Hacke Werner, Kappelle L. Jaap, Koudstaal Peter J., Leys Didier, Mas Jean-Louis, Sacco Ralph L., Algra Ale
Dátum:
2019
ISSN:
0039-2499
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Stroke. - 50 : 7 (2019), p. 1812-1818. -
További szerzők:
Diener, Hans-Christoph
Reitsma, Johannes B.
Bath, Philip M.
Csiba László (1952-) (neurológus, pszichiáter)
Hacke, Werner
Kappelle, L. Jaap
Koudstaal, Peter J.
Leys, Didier
Mas, Jean-Louis
Sacco, Ralph L.
Algra, Ale
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM063378
Első szerző:
Greving, Jacoba P.
Cím:
Individual patient data meta-analysis of antiplatelet regimens after noncardioembolic stroke or TIA : rationale and design / Jacoba P. Greving, Hans-Christoph Diener, László Csiba, Werner Hacke, L. Jaap Kappelle, Peter J. Koudstaal, Didier Leys, Jean-Louis Mas, Ralph L. Sacco, Juhani Sivenius, Ale Algra, Cerebrovascular Antiplatelet Trialists' Collaborative Group
Dátum:
2015
ISSN:
1747-4930 1747-4949
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
International Journal of Stroke 10 (2015), p. 145-150. -
További szerzők:
Diener, Hans-Christoph
Csiba László (1952-) (neurológus, pszichiáter)
Hacke, Werner
Kappelle, L. Jaap
Koudstaal, Peter J.
Leys, Didier
Mas, Jean-Louis
Sacco, Ralph L.
Sivenius, Juhani
Algra, Ale
Cerebrovascular Antiplatelet Trialists' Collaborative Group
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
5.
001-es BibID:
BIBFORM106778
035-os BibID:
(scopus)85116510813 (wos)000701327900042
Első szerző:
Hilkens, Nina A.
Cím:
Balancing Benefits and Risks of Long-Term Antiplatelet Therapy in Noncardioembolic Transient Ischemic Attack or Stroke / Hilkens Nina A., Algra Ale, Diener Hans-Christoph, Bath Philip M., Csiba László, Hacke Werner, Kappelle L. Jaap, Koudstaal Peter J., Leys Didier, Mas Jean-Louis, Sacco Ralph L., Greving Jacoba P., Cerebrovascular Antiplatelet Trialists` Collaborative Group
Dátum:
2021
ISSN:
0039-2499
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Stroke. - 52 : 10 (2021), p. 3258-3265. -
További szerzők:
Algra, Ale
Diener, Hans-Christoph
Bath, Philip M.
Csiba László (1952-) (neurológus, pszichiáter)
Hacke, Werner
Kappelle, L. Jaap
Koudstaal, Peter J.
Leys, Didier
Mas, Jean-Louis
Sacco, Ralph L.
Greving, Jacoba P.
Cerebrovascular Antiplatelet Trialists' Collaborative Group
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
6.
001-es BibID:
BIBFORM073083
Első szerző:
Hilkens, Nina A.
Cím:
Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets : S2TOP-BLEED / Nina A. Hilkens, Ale Algra, Hans-Christoph Diener, Johannes B. Reitsma, Philip M. Bath, Laszlo Csiba, Werner Hacke, L. Jaap Kappelle, Peter J. Koudstaal, Didier Leys, Jean-Louis Mas, Ralph L. Sacco, Pierre Amarenco, Leila Sissani, Jacoba P. Greving, Cerebrovascular Antiplatelet Trialists' Collaborative Group
Dátum:
2017
ISSN:
0028-3878
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Neurology 89 : 9 (2017), p. 936-943. -
További szerzők:
Algra, Ale
Diener, Hans-Christoph
Reitsma, Johannes B.
Bath, Philip M.
Csiba László (1952-) (neurológus, pszichiáter)
Hacke, Werner
Kappelle, L. Jaap
Koudstaal, Peter J.
Leys, Didier
Mas, Jean-Louis
Sacco, Ralph L.
Amarenco, Pierre
Sissani, Leila
Greving, Jacoba P.
Cerebrovascular Antiplatelet Trialists' Collaborative Group
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
7.
001-es BibID:
BIBFORM042546
Első szerző:
Putaala, Jukka
Cím:
Demographic and geographic vascular risk factor differences in European young adults with ischemic stroke :the 15 cities young stroke study / Jukka Putaala, Nilufer Yesilot, Ulrike Waje-Andreassen, Janne Pitkäniemi, Sofia Vassilopoulou, Katiuscia Nardi, Celine Odier, Gergely Hofgart, Stefan Engelter, Annika Burow, Laszlo Mihalka, Manja Kloss, Julia Ferrari, Robin Lemmens, Oguzhan Coban, Elena Haapaniemi, Noortje Maaijwee, Loes Rutten-Jacobs, Anna Bersano, Carlo Cereda, Pierluigi Baron, Linda Borellini, Caterina Valcarenghi, Lars Thomassen, Armin J. Grau, Frederick Palm, Christioan Urbanek, Rezzan Tuncay, Aysan Durukan-Tolvanen, Ewoud J. van Dijk, Frank-Erik de Leeuw, Vincent Thijs, Stefan Greisenegger, Konstantinos Vemmos, Christoph Lichy, Daniel Bereczki, Laszlo Csiba, Patrik Michel, Didier Leys, Konstantinos Spengos, Halvor Naess, Sara Zarko Bahar, Turgut Tatlisumak
Dátum:
2012
ISSN:
0039-2499
Megjegyzések:
Abstract - BACKGROUND AND PURPOSE: We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS: We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospective or consecutive young stroke registries involving 15 cities in 12 countries. Geographic regions were defined as northern (Finland, Norway), central (Austria, Belgium, France, Germany, Hungary, The Netherlands, Switzerland), and southern (Greece, Italy, Turkey) Europe. Hierarchical regression models were used for comparisons. RESULTS: In the study cohort (n=3944), the 3 most frequent risk factors were current smoking (48.7%), dyslipidemia (45.8%), and hypertension (35.9%). Compared with central (n=1868; median age, 43 years) and northern (n=1330; median age, 44 years) European patients, southern Europeans (n=746; median age, 41 years) were younger. No sex difference emerged between the regions, male:female ratio being 0.7 in those aged <34 years and reaching 1.7 in those aged 45 to 49 years. After accounting for confounders, no risk-factor differences emerged at the region level. Compared with females, males were older and they more frequently had dyslipidemia or coronary heart disease, or were smokers, irrespective of region. In both sexes, prevalence of family history of stroke, dyslipidemia, smoking, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial disease, and atrial fibrillation positively correlated with age across all regions. CONCLUSIONS: Primary preventive strategies for ischemic stroke in young adults-having high rate of modifiable risk factors-should be targeted according to sex and age at continental level.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Stroke. - 43 : 10 (2012), p. 2624-30. -
További szerzők:
Yesilot Barlas, Nilufer
Waje-Andreassen, Ulrike
Pitkäniemi, Janne
Vassilopoulou, Sofia
Nardi, Katiuscia
Odier, Celine
Hofgárt Gergely (1984-) (neurológus)
Engelter, Stefan
Burow, Annika
Mihálka László (1950-) (neurológus)
Kloss, Manja
Ferrari, Julia
Lemmens, Robin
Coban, Oguzhan
Haapaniemi, Elena
Maaijwee, Noortje
Rutten-Jacobs, Loes
Bersano, Anna
Cereda, Carlo
Baron, Pierluigi
Borellini, Linda
Valcarenghi, Caterina
Thomassen, Lars
Grau, Armin J.
Palm, Frederick
Urbanek, Christioan
Tuncay, Rezzan
Durukan-Tolvanen, Aysan
Dijk, Ewoud J. van
de Leeuw, Frank-Erik
Thijs, Vincent
Greisenegger, Stefan
Vemmos, Konstantinos
Lichy, Christoph
Bereczki Dániel (1960-) (neurológus)
Csiba László (1952-) (neurológus, pszichiáter)
Michel, Patrik
Leys, Didier
Spengos, Konstantinos
Naess, Halvor
Bahar, Sara Zarko
Tatlisumak, Turgut
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
8.
001-es BibID:
BIBFORM051019
035-os BibID:
PMID:23837733
Első szerző:
Yesilot Barlas, Nilufer
Cím:
Etiology of first-ever ischaemic stroke in European young adults : the 15 cities young stroke study / N. Yesilot Barlas, J. Putaala, U. Waje-Andreassen, S. Vassilopoulou, K. Nardi, C. Odier, G. Hofgart, S. Engelter, A. Burow, L. Mihalka, M. Kloss, J. Ferrari, R. Lemmens, O. Coban, E. Haapaniemi, N. Maaijwee, L. Rutten-Jacobs, A. Bersano, C. Cereda, P. Baron, L. Borellini, C. Valcarenghi, L. Thomassen, A. J. Grau, F. Palm, C. Urbanek, R. Tuncay, A. Durukan Tolvanen, E. J. van Dijk, F.-E. de Leeuw, V. Thijs, S. Greisenegger, K. Vemmos, C. Lichy, D. Bereczki, L. Csiba, P. Michel, D. Leys, K. Spengos, H. Naess, T. Tatlisumak, S. Z. Bahar
Dátum:
2013
ISSN:
1351-5101
Megjegyzések:
BACKGROUND AND PURPOSE: Risk factors for IS in young adults differ between genders and evolve with age, but data on the age- and gender-specific differences by stroke etiology are scare. These features were compared based on individual patient data from 15 European stroke centers. METHODS: Stroke etiology was reported in detail for 3331 patients aged 15-49 years with first-ever IS according to Trial of Org in Acute Stroke Treatment (TOAST) criteria: large-artery atherosclerosis (LAA), cardioembolism (CE), small-vessel occlusion (SVO), other determined etiology, or undetermined etiology. CE was categorized into low- and high-risk sources. Other determined group was divided into dissection and other non-dissection causes. Comparisons were done using logistic regression, adjusting for age, gender, and center heterogeneity. RESULTS: Etiology remained undetermined in 39.6%. Other determined etiology was found in 21.6%, CE in 17.3%, SVO in 12.2%, and LAA in 9.3%. Other determined etiology was more common in females and younger patients, with cervical artery dissection being the single most common etiology (12.8%). CE was more common in younger patients. Within CE, the most frequent high-risk sources were atrial fibrillation/flutter (15.1%) and cardiomyopathy (11.5%). LAA, high-risk sources of CE, and SVO were more common in males. LAA and SVO showed an increasing frequency with age. No significant etiologic distribution differences were found amongst southern, central, or northern Europe. CONCLUSIONS: The etiology of IS in young adults has clear gender-specific patterns that change with age. A notable portion of these patients remains without an evident stroke mechanism according to TOAST criteria.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
European Journal of Neurology 20 : 11 (2013), p. 1431-1439. -
További szerzők:
Putaala, Jukka
Waje-Andreassen, Ulrike
Vassilopoulou, Sofia
Nardi, Katiuscia
Odier, Celine
Hofgárt Gergely (1984-) (neurológus)
Engelter, Stefan
Burow, Annika
Mihálka László (1950-) (neurológus)
Kloss, Manja
Ferrari, Julia
Lemmens, Robin
Coban, Oguzhan
Haapaniemi, Elena
Maaijwee, Noortje
Rutten-Jacobs, Loes
Bersano, Anna
Cereda, Carlo
Baron, Pierluigi
Borellini, Linda
Valcarenghi, Caterina
Thomassen, Lars
Grau, Armin J.
Palm, Frederick
Urbanek, Christioan
Tuncay, Rezzan
Durukan-Tolvanen, Aysan
Dijk, Ewoud J. van
de Leeuw, Frank-Erik
Thijs, Vincent
Greisenegger, Stefan
Vemmos, Konstantinos
Lichy, Christoph
Bereczki Dániel (1960-) (neurológus)
Csiba László (1952-) (neurológus, pszichiáter)
Michel, Patrik
Leys, Didier
Spengos, Konstantinos
Naess, Halvor
Tatlisumak, Turgut
Bahar, Sara Zarko
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
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