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001-es BibID:BIBFORM036053
Első szerző:Touboul, P. J.
Cím:Mannheim Carotid Intima-Media Thickness Consensus (2004-2006) : an update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006 / Touboul, P.-J., Hennerici, M. G., Meairs, S., Adams, H., Amarenco, P., Bornstein, N., Csiba, L., Desvarieux, M., Ebrahim, S., Fatar, M., Hernandez Hernandez, R., Jaff, M., Kownator, S., Prati, P., Rundek, T., Sitzer, M., Schminke, U., Tardif, Jean-Claude, Taylor, A., Vicaut, E., Woo, K. S., Zannad, F., Zureik, M.
Dátum:2007
ISSN:1015-9770
Megjegyzések:Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success of interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction and peripheral artery diseases). The necessity to promote further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT and to standardize IMT measurements is expressed through this updated consensus. Plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. Standard use of IMT measurements is based on physics, technical and disease-related principles as well as agreements on how to perform, interpret and document study results. Harmonization of carotid image acquisition and analysis is needed for the comparison of the IMT results obtained from epidemiological and interventional studies around the world. The consensus concludes that there is no need to 'treat IMT values' nor to monitor IMT values in individual patients apart from exceptions named, which emphasize that inside randomized clinical trials should be performed. Although IMT has been suggested to represent an important risk marker, according to the current evidence it does not fulfill the characteristics of an accepted risk factor. Standardized methods recommended in this consensus statement will foster homogenous data collection and analysis. This will help to improve the power of randomized clinical trials incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular Diseases 23 : 1 (2007), p. 75-80. -
További szerzők:Hennerici, M. Meairs, S. Adams, H. Amarenco, Pierre Bornstein, N. Csiba László (1952-) (neurológus, pszichiáter) Desvarieux, M. Ebrahim, S. Fatar, M. Hernandez Hernandez, R. Jaff, M. Kownator, S. Prati, P. Rundek, T. Sitzer, M. Schminke, U. Tardif, Jean-Claude Taylor, A. Vicaut, E. Woo, K. S. Zannad, Faiez Zureik, M.
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DOI
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001-es BibID:BIBFORM029311
Első szerző:Touboul, P. J.
Cím:Mannheim Intima-Media Thickness Consensus on Behalf of the Advisory Board of the 3rd Watching the Risk Symposium 2004 / Touboul, P. J., Hennerici, G., Meairs, S., Adams, H., Amarenco, P., Desvarieux, M., Ebrahim, S., Fatar, M., Hernandez, R. H., Kownator, S., Prati, P., Rundek, T., Taylor, A., Bornstein, N., Csiba, L., Vicaut, E., Woo, K. S., Zannad, F.
Dátum:2004
ISSN:1015-9770
Megjegyzések:Intima-media thickness (IMT) is increasingly used in clinical trials as a surrogate end point for determining the success of interventions that lower risk factors for atherosclerosis. The necessity for unified criteria to distinguish early atherosclerotic plaque formation from thickening of IMT and to standardize IMT measurements is addressed in this consensus statement. Plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness of > or =1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. Standard use of IMT measurements is recommended in all epidemiological and interventional trials dealing with vascular diseases to improve characterization of the population investigated. The consensus concludes that there is no need to 'treat IMT values' nor to monitor IMT values in individual patients apart from few exceptions. Although IMT has been suggested to represent an important risk marker, it does not fulfill the characteristics of an accepted risk factor. Standardized methods recommended in this consensus statement will foster homogenous data collection and analysis. This will help to improve the power of studies incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular Diseases 18 : 4 (2004), p. 346-349. -
További szerzők:Hennerici, G. Meairs, S. Adams, H. Amarenco, Pierre Desvarieux, M. Ebrahim, S. Fatar, M. Hernandez, R. H. Kownator, S. Prati, P. Rundek, T. Taylor, A. Bornstein, N. Csiba László (1952-) (neurológus, pszichiáter) Vicaut, E. Woo, K. S. Zannad, Faiez
Internet cím:DOI
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