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1.

001-es BibID:BIBFORM063379
Első szerző:Karlinski, Michal
Cím:Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event / Michal Karlinski, Adam Kobayashi, Anna Czlonkowska, Robert Mikulik, Daniel Vaclavik, Miroslav Brozman, Zuzana Gdovinova, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Vanja Bašic-Kes, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Nikolay Shamalov, Silva Andonova, Niaz Ahmed, Nils Wahlgren
Dátum:2015
ISSN:0039-2499
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke 46 : 11 (2015), p. 3184-3189. -
További szerzők:Kobayashi, Adam Czlonkowska, Anna Mikulík, Robert Vaclavik, Daniel Brozman, Miroslav Gdovinova, Zuzana Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Bašic-Kes, Vanja Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Shamalov, Nikolay Andonova, Silva Ahmed, Niaz Wahlgren, Nils
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2.

001-es BibID:BIBFORM050397
Első szerző:Karlinski, Michal
Cím:Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke / Michal Karlinski, Adam Kobayashi, Anna Czlonkowska, Robert Mikulik, Daniel Vaclavik, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Niaz Ahmed, Nils Wahlgren, Safe Implementation of Treatments in Stroke-Eastern Europe (SITS-EAST) Investigators
Dátum:2014
ISSN:0039-2499
Megjegyzések:BACKGROUND AND PURPOSE:Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.METHODS:We analyzed the data of all stroke patients admitted between October 2003 and December 2011 that were contributed to the Safe Implementation of Treatments in Stroke-Eastern Europe (SITS-EAST) registry. Patients with no prestroke disability at all (modified Rankin Scale [mRS] score, 0) were used as a reference in multivariable logistic regression.RESULTS:Of 7250 patients, 5995 (82%) had prestroke mRS 0, 791 (11%) had prestroke mRS 1, 293 (4%) had prestroke mRS 2, and 171 (2%) had prestroke mRS ?3. Compared with patients with mRS 0, all other groups were older, had more comorbidities, and more severe neurological deficit on admission. There was no clear association between preexisting disability and the risk of symptomatic intracranial hemorrhage. Prestroke mRS 1, 2, and ?3 were associated with increased risk of death at 3 months (odds ratio, 1.3, 2.0, and 2.6, respectively) and lower chance of achieving favorable outcome (achieving mRS 0-2 or returning to the prestroke mRS; 0.80, 0.41, 0.59, respectively). Patients with mRS ?3 and 2 had similar vascular profile and favorable outcome (34% versus 29%), despite higher mortality (48% versus 39%).CONCLUSIONS:Prestroke disability does not seem to independently increase the risk of symptomatic intracranial hemorrhage after thrombolysis. Despite higher mortality, 1 in 3 previously disabled patients may return to his/her prestroke mRS. Therefore, they should not be routinely excluded from thrombolytic therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke. - 45 : 3 (2014), p. 770-775. -
További szerzők:Kobayashi, Adam Czlonkowska, Anna Mikulík, Robert Vaclavik, Daniel Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz Wahlgren, Nils Safe Implementation of Treatments in Stroke-Eastern Europe (SITS-EAST) Investigators
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3.

001-es BibID:BIBFORM049534
Első szerző:Kõrv, Janika
Cím:Benefit of thrombolysis for stroke is maintained around the clock : results from the SITS-EAST Registry / J. Kõrv, R. Vibo, P. Kadlecová, A. Kobayashi, A. Czlonkowska, M. Brozman, V. Švigelj, L. Csiba, K. Fekete, V. Demarin, A. Vilionskis, D. Jatuzis, Y. Krespi, N. Ahmed, R. Mikulík, the Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
Dátum:2014
ISSN:1351-5101
Megjegyzések:Background and purpose: The outcome of thrombolysis for early morning and sleeptime strokes may be worse because of uncertainty of stroke onset time or differencesin logistics. The aim of the study was to analyze if stroke outcome after intravenousthrombolysis differs depending on time of day when the stroke occurs.Methods: The data collected in the Safe Implementation of Treatments in Stroke Eastern Europe (SITS-EAST) Registry between September 2000 and December2011 were used. Strokes were categorized as night-time 00:00?07:59, day-time08:00?15:59 and evening-time 16:00?23:59 and were compared in terms of severaloutcome measures. All results were adjusted for baseline differences.Results: A total of 8878 patients were enrolled: 18% had night-time, 54% day-timeand 28% evening-time strokes. Onset-to-treatment time in patients with night-timestrokes was 10 min longer than in day-time and evening-time strokes (P < 0.001).Symptomatic intracerebral hemorrhage by ECASS II definition occurred in 5.6%,5.6% and 5.3% (adjusted P = 0.41) of the night-time, day-time and evening-timestroke patients, respectively; by SITS definition it occurred in 2.5%, 1.9% and 1.3%(adjusted P = 0.013) and by NINDS definition in 7.8%, 7.6% and 7.5% (adjustedP = 0.74). Patients with night-time, day-time and evening-time strokes achievedmodified Rankin Scale score 0?1 in 33%, 31%, 31% (adjusted P = 0.34) and 0?2 in52%, 51%, 50% (adjusted P = 0.23), and 13%, 15%, 16% respectively of patientsdied (adjusted P = 0.17) by 3 months.Conclusions: The time when stroke occurs (day versus evening versus night) doesnot affect the outcome after thrombolysis despite the fact that patients with nighttimestrokes have worse time management.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circadian variation
mRS
NIHSS
outcome
SITS
stroke
symptomatic intracerebral haemorrhage
trhombolysis
Megjelenés:European Journal of Neurology 21 : 1 (2014), p. 112-117. -
További szerzők:Vibo, R. Kadlecova, Pavla Kobayashi, Anna Czlonkowska, A. Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz Mikulík, Robert The Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
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4.

001-es BibID:BIBFORM042545
Első szerző:Mikulík, Robert
Cím:Factors influencing in-hospital delay in treatment with intravenous thrombolysis / Robert Mikulík, Pavla Kadlecova, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Victor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Niaz Ahmed
Dátum:2012
ISSN:0039-2499
Megjegyzések:Background: Shortening door-to-needle time (DNT) for the thrombolytic treatment of strokecan improve treatment efficacy by reducing onset-to-treatment time. The goal of our studywas to explore the association between DNT and outcome and to identify factors influencingDNT to better understand why some patients are treated late.Methods: Prospectively collected data from the Safe Implementation of Treatments in Stroke-East registry (SITS-EAST: nine Central and Eastern European countries) on all patientstreated with thrombolysis between February/2003 and February/2010 were analyzed. Multiplelogistic regression analysis was used to identify predictors of DNT?60 minutes.Results: Altogether, 5563 patients were treated with thrombolysis within 4.5 hours ofsymptom onset. Of these, 2097 (38%) had DNT?60 minutes. In different centers, theproportion of patients treated with DNT?60 minutes ranged from 18 to 84% (p<0.0001).Patients with longer DNT (in 60 minute increments) had less chance of achieving modifiedRankin scale 0-1 at 3 month (adjusted OR 0.86, 95%CI 0.77 to 0.97). DNT?60 minutes wasindependently predicted by younger age (in 10 year increments, OR 0.92, 95%CI 0.87 to0.97), NIHSS score 7-24 (OR 1.44, 95%CI 1.2 to 1.7), onset-to-door time (in 10 minuteincrements, OR 1.19, 95%CI 1.17 to 1.22), treatment center (p<0.001), and country(p<0.001).Conclusions: Thrombolysis of patients with older age and mild or severe neurological deficitis delayed. The perception that there is sufficient time before the end of thrombolytic windowalso delays treatment. It is necessary to improve adherence to guidelines and to treat patientssooner after arrival to hospital.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke. - 43 : 6 (2012), p. 1578-1583. -
További szerzők:Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz
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5.

001-es BibID:BIBFORM105087
035-os BibID:(scopus)85138547393 (wos)000875091000001
Első szerző:Shoamanesh, Ashkan
Cím:Factor Xla inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke) : an international, randomised, double-blind, placebo-controlled, phase 2b trial / Ashkan Shoamanesh, Hardi Mundl, Eric E. Smith, Jaime Masjuan, Ivan Milanov, Teruyuki Hirano, Alina Agafina, Bruce Campbell, Valeria Caso, Jean-Louis Mas, Qiang Dong, Peter Turcani, Hanne Christensen, Jose M. Ferro, Roland Veltkamp, Robert Mikulik, Gian Marco De Marchis, Thompson Robinson, Robin Lemmens, Adam Stepien, Stefan Greisenegger, Risto Roine, Laszlo Csiba, Pooja Khatri, Jonathan Coutinho, Arne G. Lindgren, Andrew M. Demchuk, Pablo Colorado, Bodo Kirsch, Christoph Neumann, Laura Heenan, Lizhen Xu, Stuart J. Connolly, Robert G. Hart, PACIFIC-Stroke Investigators
Dátum:2022
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Lancet. - 400 : 10357 (2021), p. 997-1007. -
További szerzők:Mundl, Hardi Smith, Eric E. Masjuan, Jaime Milanov, Ivan Hirano, Teruyuki Agafina, Alina Campbell, Bruce Caso, Valeria Mas, Jean-Louis Dong, Qiang Turcani Péter Christensen, Hanne Ferro, Jose M. Veltkamp, Roland Mikulík, Robert De Marchis, Gian Marco Robinson, Thompson Lemmens, Robin Stepien, Adam Greisenegger, Stefan Roine, Risto Csiba László (1952-) (neurológus, pszichiáter) Khatri, Pooja Coutinho, Jonathan Lindgren, Arne G. Demchuk, Andrew M. Colorado, Pablo Kirsch, Bodo Neumann, Christoph Heenan, Laura Xu, Lizhen Connolly, Stuart J. Hart, Robert G. PACIFIC-Stroke Investigators
Pályázati támogatás:Bayer AG.
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6.

001-es BibID:BIBFORM091004
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for ischemic stroke in the golden hour : propensity-matched analysis from the SITS-EAST registry / Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecova, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Körv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Chrissoula Liantinioti, Sotirios Giannopoulos, Robert Mikulik
Dátum:2017
ISSN:0340-5354
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Neurology. - 264 : 5 (2017), p. 912-920. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Körv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Liantinioti, Chrissoula Giannopoulos, Sotirios Mikulík, Robert
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7.

001-es BibID:BIBFORM079857
035-os BibID:(cikkazonosító)AS08-015
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for patients with in-hospital stroke onset : propensity-matched analysis from the SITS-EAST registry / G. Tsivgoulis, A. H. Katsanos, P. Kadlecova, A. Czlonkowska, A. Kobayashi, M. Brozman, V. Švigelj, L. Csiba, K. Fekete, J. Kõrv, V. Demarin, A. Vilionskis, D. Jatuzis, Y. Krespi, C. Liantinioti, S. Giannopoulos, R. Mikulik
Dátum:2017
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:European Stroke Journal. - 2 : Suppl. 1 (2017), p. 71. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, A. Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin V. Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Liantinioti, Chrissoula Giannopoulos, Sotirios Mikulík, Robert
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8.

001-es BibID:BIBFORM071091
035-os BibID:(WoS)000415723800016 (Scopus)85034075239
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for patients with in-hospital stroke onset : propensity-matched analysis from the Safe Implementation of Treatments in Stroke-East registry / Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecová, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Theodore Karapanayiotides, Sotirios Giannopoulos, Robert Mikulik
Dátum:2017
ISSN:1351-5101
Megjegyzések:Introduction: Recent cross-sectional study data suggest that intravenous thrombolysis (IVT) in patients with in-hospital (IHS) acute ischemic stroke (AIS) onset is associated with unfavourable functional outcomes at hospital discharge and in-hospital mortality compared to patients with outof-hospital stroke onset (OHS) treated with IVT. We sought to compare outcomes between IVT treated IHS and OHS patients by analysing propensity score matched (PSM) data from the SITSEAST registry. Methods: We compared the following outcomes for all PSM patients: 1.symptomatic intracranial hemorrhage (sICH) defined with the SITS-MOST criteria, 2.favourable functional outcome Accepted ArticleThis article is protected by copyright. All rights reserved. (FFO) defined as a modified Rankin Scale (mRS) score of 0-1 at three months, 3.Functional independence (FI) defined as a mRS score of 0-2 at three months, 4.3-month mortality. Results: Out of total 19,077 IVT-treated AIS patients, 196 IHS patients were matched to 5124 OHS patients, with no differences in all baseline characteristics (p>0.1). IHS had longer door-to-needle [90 min (60-140) vs. 65 (47-95), p<0.001] and door-to-imaging times [40 min (20-90) vs 24 (15-35), p<0.001] compared to OHS. No differences were detected in the rates of sICH (1.6% vs 1.9%, p=0.756), FFO (46.4% vs 42.3%, p=0.257), FI (60.7% vs. 60.0%,p=0.447) and mortality (14.3% vs 15.1%,p=0.764). The distribution of 3-month mRS-scores was similar in the two groups (p=0.273). Conclusions: Our findings underline the safety and efficacy of IVT for IHS. They also underscore the potential of reducing in-hospital delays for timely tPA delivery in patients with IHS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
intravenous thrombolysis
acute ischemic stroke
in-hospital stroke
onset-to-treatment time
door-to-needle time
stroke awareness
Megjelenés:European Journal of Neurology. - 24 : 12 (2017), p. 1493-1498. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Karapanayiotides, Theodore Giannopoulos, Sotirios Mikulík, Robert
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9.

001-es BibID:BIBFORM063381
Első szerző:Tsivgoulis, Georgios
Cím:Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke / Georgios Tsivgoulis, Pavla Kadlecová, Adam Kobayashi, Anna Czlonkowska, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Aristeidis H. Katsanos, Jobst Rudolf, Yakup Krespi, Robert Mikulik
Dátum:2015
ISSN:0039-2499
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke 46 : 9 (2015), p. 2681-2684. -
További szerzők:Kadlecova, Pavla Kobayashi, Adam Czlonkowska, Anna Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Katsanos, Aristeidis H. Rudolf, Jobst Krespi, Yakup Mikulík, Robert
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