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001-es BibID:	BIBFORM049534
Első szerző:	Kõrv, Janika
Cím:	Benefit of thrombolysis for stroke is maintained around the clock : results from the SITS-EAST Registry / J. Kõrv, R. Vibo, P. Kadlecová, A. Kobayashi, A. Czlonkowska, M. Brozman, V. Švigelj, L. Csiba, K. Fekete, V. Demarin, A. Vilionskis, D. Jatuzis, Y. Krespi, N. Ahmed, R. Mikulík, the Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
Dátum:	2014
ISSN:	1351-5101
Megjegyzések:	Background and purpose: The outcome of thrombolysis for early morning and sleeptime strokes may be worse because of uncertainty of stroke onset time or differencesin logistics. The aim of the study was to analyze if stroke outcome after intravenousthrombolysis differs depending on time of day when the stroke occurs.Methods: The data collected in the Safe Implementation of Treatments in Stroke Eastern Europe (SITS-EAST) Registry between September 2000 and December2011 were used. Strokes were categorized as night-time 00:00?07:59, day-time08:00?15:59 and evening-time 16:00?23:59 and were compared in terms of severaloutcome measures. All results were adjusted for baseline differences.Results: A total of 8878 patients were enrolled: 18% had night-time, 54% day-timeand 28% evening-time strokes. Onset-to-treatment time in patients with night-timestrokes was 10 min longer than in day-time and evening-time strokes (P < 0.001).Symptomatic intracerebral hemorrhage by ECASS II definition occurred in 5.6%,5.6% and 5.3% (adjusted P = 0.41) of the night-time, day-time and evening-timestroke patients, respectively; by SITS definition it occurred in 2.5%, 1.9% and 1.3%(adjusted P = 0.013) and by NINDS definition in 7.8%, 7.6% and 7.5% (adjustedP = 0.74). Patients with night-time, day-time and evening-time strokes achievedmodified Rankin Scale score 0?1 in 33%, 31%, 31% (adjusted P = 0.34) and 0?2 in52%, 51%, 50% (adjusted P = 0.23), and 13%, 15%, 16% respectively of patientsdied (adjusted P = 0.17) by 3 months.Conclusions: The time when stroke occurs (day versus evening versus night) doesnot affect the outcome after thrombolysis despite the fact that patients with nighttimestrokes have worse time management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban circadian variation mRS NIHSS outcome SITS stroke symptomatic intracerebral haemorrhage trhombolysis
Megjelenés:	European Journal of Neurology 21 : 1 (2014), p. 112-117. -
További szerzők:	Vibo, R. Kadlecova, Pavla Kobayashi, Anna Czlonkowska, A. Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz Mikulík, Robert The Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
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