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001-es BibID:	BIBFORM086266
Első szerző:	Árkosy Péter (általános sebész, mellkassebész)
Cím:	Prognosis and Treatment Outcomes of Patients Undergoing Resection of Brain Metastases from Breast Cancer / Peter Arkosy, Judit Tóth, Edit Béres, Dezső Tóth, László Szívós, János Nagy, Almos Klekner, József Virga
Dátum:	2020
ISSN:	0250-7005 1791-7530
Megjegyzések:	Background: Brain metastases from breast cancer have poor prognosis and are a challenge to treat. Multiple treatment options are available. Descriptive and prognostic data on breast cancer brain metastases is limited. Patients and Methods: This study analyzed clinical data of patients who underwent surgical resection of one or more brain metastases. Histological and clinical characteristics, as well as treatment modalities, were analyzed. Results: Initial tumor stage or grade was found not to correlate with the median time to developing brain metastases or survival. Human epidermal growth factor receptor 2 (HER2)-positive status was not associated with shorter median time to developing brain metastases. No correlation was found between the number of brain metastases and patient outcome. Results confirm the survival benefit of surgical resection with or without irradiation. Conclusion: Data showed that patients with HER2-positive and those with triple-negative breast cancer develop brain metastases at lower stages but not earlier after diagnosis, and survival is mostly dependent on treatment modality rather than histological subtype.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk breast cancer brain metastasis molecular subtype prognosis surgical resection survival
Megjelenés:	Anticancer Research. - 40 : 3 (2020), p. 1759-1770. -
További szerzők:	Tóth Judit (1958-) (onkológus szakorvos) Béres Edit (1986-) (onkológus) Tóth Dezső (1972-) (sebész, onkológus) Szivos László (1993-) (idegsebész) Nagy János (1956-) (matematikus) Klekner Álmos (1970-) (idegsebész) Virga József (1989-)
Pályázati támogatás:	ÚNKP-19-3 Egyéb
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001-es BibID:	BIBFORM071230
Első szerző:	Virga József
Cím:	Differences in Extracellular Matrix Composition and its Role in Invasion in Primary and Secondary Intracerebral Malignancies / Virga J., Szemcsák C. D., Reményi-Puskár J., Tóth J., Hortobágyi T., Csősz É., Zahuczky G., Szivos L., Bognár L., Klekner A.
Dátum:	2017
ISSN:	0250-7005 1791-7530
Megjegyzések:	1. Anticancer Res. 2017 Aug;37(8):4119-4126.Differences in Extracellular Matrix Composition and its Role in Invasion inPrimary and Secondary Intracerebral Malignancies.Virga J(1), Szemcsák CD(1), Reményi-Puskár J(1), Tóth J(2), Hortobágyi T(3),Csősz É(4), Zahuczky G(5), Szivos L(1), Bognár L(1), Klekner A(6).Author information: (1)Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,Hungary.(2)Department of Oncology, Clinical Centre, University of Debrecen, Debrecen,Hungary.(3)Department of Neuropathology, Institute of Pathology, MTA-DE Cerebrovascularand Neurodegenerative Research Group, University of Debrecen, Debrecen, Hungary.(4)Proteomics Core Facility, Department of Biochemistry and Molecular Biology,Faculty of Medicine, University of Debrecen, Debrecen, Hungary.(5)UD-GenoMed Medical Genomic Technologies Research & Development Services Ltd., Debrecen, Hungary.(6)Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,Hungary neurosurgery.debrecen@freemail.hu.BACKGROUND/AIM: The most common malignant primary brain tumor is glioblastomawhich infiltrates the peritumoral brain, while secondary brain metastases arewell demarcated malignancies. Previous research has proved the pivotal role ofthe changes in the extracellular matrix (ECM) in cancer cell invasion.MATERIALS AND METHODS: The mRNA expression of 40 ECM molecules was determinedusing qRT-PCR in 54 fresh-frozen glioblastoma and brain metastasis samples.Seventy-two samples were used to determine the levels of 20 ECM proteins.RESULTS: The mRNA and protein expression pattern of the studied tumors differsgreatly. Linear discriminant analysis of mRNA expression identified samples basedon their mRNA expression profile with 92.3% probability and highlighted the role of some molecules as their level greatly influenced sample identification.CONCLUSION: Different tumor types with different invasiveness differ in thecomposition of their ECM and this can be used to identify samples. Furthermore,some ECM molecules greatly contribute to tumor invasiveness and could be targets of anti-invasive oncotherapy.Copyright? 2017, International Institute of Anticancer Research (Dr. George J.Delinasios), All rights reserved.DOI: 10.21873/anticanres.11799 PMID: 28739696 [Indexed for MEDLINE]
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Anticancer Research 37 : 8 (2017), p. 4119-4126. -
További szerzők:	Szemcsák Csaba D. Reményi-Puskár Judit Tóth Judit (1958-) (onkológus szakorvos) Hortobágyi Tibor (1965-) (patológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus) Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Szivos László (1993-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Klekner Álmos (1970-) (idegsebész)
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