Találati lista | Tudóstér

001-es BibID:	BIBFORM062336
Első szerző:	Fontebasso, Adam M.
Cím:	Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age / Adam M. Fontebasso, Margret Shirinian, Dong-Anh Khuong-Quang, Denise Bechet, Tenzin Gayden, Marcel Kool, Nicolas De Jay, Karine Jacob, Noha Gerges, Barbara Hutter, Huriye Şeker-Cin, Hendrik Witt, Alexandre Montpetit, Sébastien Brunet, Pierre Lepage, Geneviève Bourret, Almos Klekner, László Bognár, Peter Hauser, Miklós Garami, Jean-Pierre Farmer, Jose-Luis Montes, Jeffrey Atkinson, Sally Lambert, Tony Kwan, Andrey Korshunov, Uri Tabori, V. Peter Collins, Steffen Albrecht, Damien Faury, Stefan M. Pfister, Werner Paulus, Martin Hasselblatt, David T. W. Jones, Nada Jabado
Dátum:	2015
ISSN:	1949-2553
Megjegyzések:	Pilocytic astrocytoma (PA) is the most common brain tumor in children but israre in adults, and hence poorly studied in this age group. We investigated 222 PA andreport increased aneuploidy in older patients. Aneuploid genomes were identified in45% of adult compared with 17% of pediatric PA. Gains were non-random, favoringchromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting noncerebellarPA and tumors with BRAF V600E mutations and not with KIAA1549-BRAFfusions or FGFR1 mutations. Aneuploid PA differentially expressed genes involved inCNS development, the unfolded protein response, and regulators of genomic stabilityand the cell cycle (MDM2, PLK2), whose correlated programs were overexpressedspecifically in aneuploid PA compared to other glial tumors. Thus, convergence of pathways affecting the cell cycle and genomic stability may favor aneuploidy in PA, possiblyrepresenting an additional molecular driver in older patients with this brain tumor.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban pilocytic astrocytoma aneuploidy BRAF MDM2 PLK2
Megjelenés:	Oncotarget. - 6 : 31 (2015), p. 31844-31856. -
További szerzők:	Shirinian, Margret Khuong-Quang, Dong-Anh Bechet, Denise Gayden, Tenzin Kool, Marcel De Jay, Nicolas Jacob, Karine Gerges, Noha Hutter, Barbara Şeker-Cin, Huriye Witt, Hendrik Montpetit, Alexandre Brunet, Sébastien Lepage, Pierre Bourret, Geneviève Klekner Álmos (1970-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Hauser Péter Garami Miklós Farmer, Jean-Pierre Montes, Jose-Luis Atkinson, Jeffrey Lambert, Sally Kwan, Tony Korshunov, Andrey Tabori, Uri Collins, V. Peter Albrecht, Stephen Faury, Damien Pfister, Stefan M. Paulus, Werner Hasselblatt, Martin Jones, David T. W. Jabado, Nada
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM068928
Első szerző:	Murnyák Balázs (molekuláris biológus, genetikus)
Cím:	PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma / Balázs Murnyák, Mahan C. Kouhsari, Rotem Hershkovitch, Bernadette Kálmán, György Marko-Varga, Álmos Klekner, Tibor Hortobágyi
Dátum:	2017
ISSN:	1949-2553
Megjegyzések:	Overexpression of PARP1 exists in various cancers, including glioblastoma (GBM). Although PARP1 inhibition is a promising therapeutic target, no comprehensive study has addressed PARP1's expression characteristics and prognostic role regarding molecular heterogeneity in astrocytomas including GBM. Our aim was to evaluate PARP1's associations with survival, WHO grade, lineage specific markers, and GBM transcriptomic subtypes. We collected genomic and clinical data from the latest glioma datasets of The Cancer Genome Atlas and performed PARP1, ATRX, IDH1, and p53 immunohistochemistry on GBM tissue samples. We demonstrated that PARP1 gain and increased mRNA expression are characteristics of high-grade astrocytomas, particularly of Proneural and Classical GBM subtypes. Additionally, higher PARP1 levels exhibited an inverse correlation with patient survival (p<0.005) in the Classical subgroup. ATRX (p=0.006), and TP53 (p=0.015) mutations were associated with increased PARP1 expression and PARP1 protein level correlated with ATRX loss and p53 overexpression. Furthermore, higher PARP1 expression together with wildtype TP53 indicated shorter survival (p=0.039). Therefore, due to subtype specificity, PARP1 expression level and TP53 mutation status are reliable marker candidates to distinguish Proneural and Classical subtypes, with prognostic and therapeutic implications in GBM.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban glioma glioblastoma p53 PARP1
Megjelenés:	Oncotarget. - 8 : 28 (2017), p. 46348-46362. -
További szerzők:	Kouhsari, Mahan C. Hershkovitch, Rotem Kálmán Bernadette Marko-Varga György Klekner Álmos (1970-) (idegsebész) Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	ÚNKP-16-3 Egyéb KTIA_13_NAP-A-II/7 Egyéb KTIA_13_NAP-A-V/3 Egyéb AGR_PIAC_13-1-2013-0008 Egyéb GINOP-2.3.2-15-2016-00043 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: