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001-es BibID:	BIBFORM016453
Első szerző:	Andrási Melinda (gyógyszerész)
Cím:	Analysis and stability study of temozolomide using capillary electrophoresis / Melinda Andrasi, Rose Bustos, Attila Gaspar, Frank A. Gomez, Almos Klekner
Dátum:	2010
ISSN:	1570-0232
Megjegyzések:	The applicability of micellar electrokinetic capillary chromatography (MEKC) for the analysis of ternozolomide (TMZ) and its degradants, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) and 5-amino-imidazole-4-carboxamide (AlC) has been studied. Using short-end injection, the analysis of TMZ and its degradants could be performed within 1.2 min. The obtained precision of migration times was better than 1.6 RSD%, and the limit of quantitation (LOQ) was 0.31-0.93 mu g/mL. The therapeutic concentration of TMZ in blood samples can be determined after direct sample injection and conventional on-capillary UV detection. The proposed MEKC method was applied to study the stability of TMZ in water and serum at different pH values. It was established that the half-life of the TMZ in vitro serum at room temperature was 33 min, close to the half-life (28 min) obtained in water at pH 7.9. (C) 2010 Elsevier B.V. All rights reserved.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Micellar electrokinetic capillary chromatography Temozolomide Solution stability antitumor agent temozolomide advanced solid malignancies human plasma phase-i intravenous temozolomide advanced cancer pharmacokinetics dacarbazine activation product
Megjelenés:	Journal of Chromatography B. - 878 : 21 (2010), p. 1801-1808. -
További szerzők:	Bustos, Rose Gáspár Attila (1970-) (vegyész, kémikus) Gomez, Frank A. Klekner Álmos (1970-) (idegsebész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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