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Dátum csökkenő
1.
001-es BibID:
BIBFORM040478
Első szerző:
Northcott, Paul A.
Cím:
Subgroup-specific structural variation across 1,000 medulloblastoma genomes / Paul A. Northcott, David J. H. Shih, John Peacock, Livia Garzia, A. Sorana Morrissy, Thomas Zichner, Adrian M. Stütz, Andrey Korshunov, Jüri Reimand, Steven E. Schumacher, Rameen Beroukhim, David W. Ellison, Christian R. Marshall, Anath C. Lionel, Stephen Mack, Adrian Dubuc, Yuan Yao, Vijay Ramaswamy, Betty Luu, Adi Rolider, Florence M. G. Cavalli, Xin Wang, Marc Remke, Xiaochong Wu, Readman Y. B. Chiu, Andy Chu, Eric Chuah, Richard D. Corbett, Gemma R. Hoad, Shaun D. Jackman, Yisu Li, Allan Lo, Karen L. Mungall, Ka Ming Nip, Jenny Q. Qian, Anthony G. J. Raymond, Nina Thiessen, Richard J. Varhol, Inanc Birol, Richard A. Moore, Andrew J. Mungall, Robert Holt, Daisuke Kawauchi, Martine F. Roussel, Marcel Kool, David T. W. Jones, Hendrick Witt, Africa Fernandez-L, Anna M. Kenney, Robert J. Wechsler-Reya, Peter Dirks, Tzvi Aviv, Wieslawa A. Grajkowska, Marta Perek-Polnik, Christine C. Haberler, Olivier Delattre, Stéphanie S. Reynaud, François F. Doz, Sarah S. Pernet-Fattet, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Wolfram Scheurlen, Charles G. Eberhart, Michelle Févre-Montange, Anne Jouvet, Ian F. Pollack, Xing Fan, Karin M. Muraszko, G. Yancey Gillespie, Concezio Di Rocco, Luca Massimi, Erna M. C. Michiels, Nanne K. Kloosterhof, Pim J. French, Johan M. Kros, James M. Olson, Richard G. Ellenbogen, Karel Zitterbart, Leos Kren, Reid C. Thompson, Michael K. Cooper, Boleslaw Lach, Roger E. McLendon, Darell D. Bigner, Adam Fontebasso, Steffen Albrecht, Nada Jabado, Janet C. Lindsey, Simon Bailey, Nalin Gupta, William A. Weiss, László Bognár, Almos Klekner, Timothy E. Van Meter, Toshihiro Kumabe, Teiji Tominaga, Samer K. Elbabaa, Jeffrey R. Leonard, Joshua B. Rubin, Linda M. Liau, Erwin G. Van Meir, Maryam Fouladi, Hideo Nakamura, Giuseppe Cinalli, Miklós Garami, Peter Hauser, Ali G. Saad, Achille Iolascon, Shin Jung, Carlos G. Carlotti, Rajeev Vibhakar, Young Shin Ra, Shenandoah Robinson, Massimo Zollo, Claudia C. Faria, Jennifer A. Chan, Michael L. Levy, Poul H. B. Sorensen, Matthew Meyerson, Scott L. Pomeroy, Yoon-Jae Cho, Gary D. Bader, Uri Tabori, Cynthia E. Hawkins, Eric Bouffet, Stephen W. Scherer, James T. Rutka, David Malkin, Steven C. Clifford, Steven J. M. Jones, Jan O. Korbe, Stefan M. Pfister, Marco A. Marra, Michael D. Taylor
Dátum:
2012
ISSN:
0028-0836
Megjegyzések:
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4?. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-? signalling in Group 3, and NF-?B signalling in Group 4, suggest future avenues for rational, targeted therapy.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:
Nature. - 488 : 7409 (2012), p. 49-56. -
További szerzők:
Shih, David J. H.
Peacock, John
Garzia, Livia
Sorana Morrissy, A.
Zichner, Thomas
Stütz, Adrian M.
Korshunov, Andrey
Reimand, Jüri
Schumacher, Steven E.
Beroukhim, Rameen
Ellison, David W.
Marshall, Christian R.
Lionel, Anath C.
Mack, Stephen
Dubuc, Adrian
Yao, Yuan
Ramaswamy, Vijay
Luu, Betty
Rolider, Adi
Cavalli, Florence M. G.
Wang, Xin
Remke, Marc
Wu, Xiaochong
Chiu, Readman Y. B.
Chu, Andy
Chuah, Eric
Corbett, Richard D.
Hoad, Gemma R.
Jackman, Shaun D.
Li, Yisu
Lo, Allan
Mungall, Karen L.
Ming Nip, Ka
Qian, Jenny Q.
Raymond, Anthony G. J.
Thiessen, Nina
Varhol, Richard J.
Birol, Inanc
Moore, Richard A.
Mungall, Andrew J.
Holt, Robert
Kawauchi, Daisuke
Roussel, Martine F.
Kool, Marcel
Jones, David T. W.
Witt, Hendrik
Fernandez-L, Africa
Kenney, Anna M.
Wechsler-Reya, Robert J.
Dirks, Peter
Aviv, Tzvi
Grajkowska, Wieslawa A.
Perek-Polnik, Marta
Haberler, Christine
Delattre, Olivier
Reynaud, Stéphanie S.
Doz, François F.
Pernet-Fattet, Sarah S.
Cho, Byung-Kyu
Kim, Seung-Ki
Wang, Kyu-Chang
Scheurlen, Wolfram
Eberhart, Charles G.
Fèvre-Montange, Michelle
Jouvet, Anne
Pollack, Ian F.
Fan, Xing
Muraszko, Karin M.
Yancey Gillespie, G.
Di Rocco, Concezio
Massimi, Luca
Michiels, Erna M. C.
Kloosterhof, Nanne K.
French, Pim J.
Kros, Johan M.
Olson, James M.
Ellenbogen, Richard G.
Zitterbart, Karel
Kren, Leos
Thompson, Reid C.
Cooper, Michael K.
Lach, Boleslaw
McLendon, Roger E.
Bigner, Darell
Fontebasso, Adam M.
Albrecht, Stephen
Jabado, Nada
Lindsey, Janet C.
Bailey, Simon
Gupta, Nalin
Weiss, William A.
Bognár László (1958-) (idegsebész, gyermekidegsebész)
Klekner Álmos (1970-) (idegsebész)
van Meter, Timothy E.
Kumabe, Toshihiro
Tominaga, Teiji
Elbabaa, Samer K.
Leonard, Jeffrey R.
Rubin, Joshua B.
Liau, Linda M.
van Meir, Erwin G.
Fouladi, Maryam
Nakamura, Hideo
Cinalli, Giuseppe
Garami Miklós
Hauser, Peter
Saad, Ali G.
Iolascon, Achille
Jung, Shin
Carlotti, Carlos G.
Vibhakar, Rajeev
Shin Ra, Young
Robinson, Shenandoah
Zollo, Massimo
Faria, Claudia C.
Chan, Jennifer A.
Levy, Michael L.
Sorensen, Poul H. B.
Meyerson, Matthew
Pomeroy, Scott L.
Cho, Yoon-Jae
Bader, Gary D.
Tabori, Uri
Hawkins, Cynthia E.
Bouffet, Eric
Scherer, Stephen W.
Rutka, James T.
Malkin, David
Clifford, Steven C.
Jones, Steven J. M.
Korbe, Jan O.
Pfister, Stefan M.
Marra, Marco A.
Taylor, Michael D.
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM052715
Első szerző:
Shih, David J. H.
Cím:
Cytogenetic prognostication within medulloblastoma subgroups / David J. H. Shih, Paul A. Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M. G. Cavalli, David T. W. Jones, Karel Zitterbart, Claudia C. Faria, Ulrich Schüller, Leos Kren, Toshihiro Kumabe, Teiji Tominaga, Young Shin Ra, Miklós Garami, Peter Hauser, Jennifer A. Chan, Shenandoah Robinson, László Bognár, Almos Klekner, Ali G. Saad, Linda M. Liau, Steffen Albrecht, Adam Fontebasso, Giuseppe Cinalli, Pasqualino De Antonellis, Massimo Zollo, Michael K. Cooper, Reid C. Thompson, Simon Bailey, Janet C. Lindsey, Concezio Di Rocco, Luca Massimi, Erna M. C. Michiels, Stephen W. Scherer, Joanna J. Phillips, Nalin Gupta, Xing Fan, Karin M. Muraszko, Rajeev Vibhakar, Charles G. Eberhart, Maryam Fouladi, Boleslaw Lach, Shin Jung, Robert J. Wechsler-Reya, Michelle Fèvre-Montange, Anne Jouvet, Nada Jabado, Ian F. Pollack, William A. Weiss, Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Jeffrey R. Leonard, Joshua B. Rubin, Carmen de Torres, Cinzia Lavarino, Jaume Mora, Yoon-Jae Cho, Uri Tabori, James M. Olson, Amar Gajjar, Roger J. Packer, Stefan Rutkowski, Scott L. Pomeroy, Pim J. French, Nanne K. Kloosterhof, Johan M. Kros, Erwin G. Van Meir, Steven C. Clifford, Franck Bourdeaut, Olivier Delattre, François F. Doz, Cynthia E. Hawkins, David Malkin, Wieslawa A. Grajkowska, Marta Perek-Polnik, Eric Bouffet, James T. Rutka, Stefan M. Pfister, Michael D. Taylor
Dátum:
2014
ISSN:
0732-183X 1527-7755
Megjegyzések:
Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication.Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models.Results Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas.Conclusion Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Journal of Clinical Oncology. - 32 : 9 (2014), p. 886-896. -
További szerzők:
Northcott, Paul A.
Remke, Marc
Korshunov, Andrey
Ramaswamy, Vijay
Kool, Marcel
Luu, Betty
Yao, Yuan
Wang, Xin
Dubuc, Adrian
Garzia, Livia
Peacock, John
Mack, Stephen
Wu, Xiaochong
Rolider, Adi
Morrissy, Sorana
Cavalli, Florence M. G.
Jones, David T. W.
Zitterbart, Karel
Faria, Claudia C.
Schüller, Ulrich
Kren, Leos
Kumabe, Toshihiro
Tominaga, Teiji
Shin Ra, Young
Garami Miklós
Hauser, Peter
Chan, Jennifer A.
Robinson, Shenandoah
Bognár László (1958-) (idegsebész, gyermekidegsebész)
Klekner Álmos (1970-) (idegsebész)
Saad, Ali G.
Liau, Linda M.
Albrecht, Stephen
Fontebasso, Adam M.
Cinalli, Giuseppe
De Antonellis, Pasqualino
Zollo, Massimo
Cooper, Michael K.
Thompson, Reid C.
Bailey, Simon
Lindsey, Janet C.
Di Rocco, Concezio
Massimi, Luca
Michiels, Erna M. C.
Scherer, Stephen W.
Phillips, Joanna J.
Gupta, Nalin
Fan, Xing
Muraszko, Karin M.
Vibhakar, Rajeev
Eberhart, Charles G.
Fouladi, Maryam
Lach, Boleslaw
Jung, Shin
Wechsler-Reya, Robert J.
Fèvre-Montange, Michelle
Jouvet, Anne
Jabado, Nada
Pollack, Ian F.
Weiss, William A.
Lee, Ji-Yeoun
Cho, Byung-Kyu
Kim, Seung-Ki
Wang, Kyu-Chang
Leonard, Jeffrey R.
Rubin, Joshua B.
Torres, Carmen, de
Lavarino, Cinzia
Mora, Jaume
Cho, Yoon-Jae
Tabori, Uri
Olson, James M.
Gajjar, Amar
Packer, Roger J.
Rutkowski, Stefan
Pomeroy, Scott L.
French, Pim J.
Kloosterhof, Nanne K.
Kros, Johan M.
van Meir, Erwin G.
Clifford, Steven C.
Bourdeaut, Franck
Delattre, Olivier
Doz, François F.
Hawkins, Cynthia E.
Malkin, David
Grajkowska, Wieslawa A.
Perek-Polnik, Marta
Bouffet, Eric
Rutka, James T.
Pfister, Stefan M.
Taylor, Michael D.
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM063328
Első szerző:
Thompson, Eric M.
Cím:
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis / Eric M. Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E. McLendon, Darell D. Bigner, Eric S. Lipp, Sebastien Perreault, Yoon-Jae Cho, Gerald Grant, Seung-Ki Kim, Ji Yeoun Lee, Amulya A. Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho-Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wieslawa A. Grajkowska, Marta Perek-Polnik, David C.Y. Low, Wan Tew Seow, Kenneth T.E. Chang, Jaume Mora, Ian F. Pollack, Ronald L. Hamilton, Sarah Leary, Andrew S. Moore, Wendy J. Ingram, Andrew R. Hallahan, Anne Jouvet, Michelle Fèvre-Montange, Alexandre Vasiljevic, Cecile Faure-Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G. Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Sterba, Leos Kren, Tibor Hortobágyi, Almos Klekner, Bognár László, Tímea Pócza, Peter Hauser, Ulrich Schüller, Shin Jung, Woo-Youl Jang, Pim J. French, Johan M. Kros, Marie-Lise C. van Veelen, Luca Massimi, Jeffrey R. Leonard, Joshua B. Rubin, Rajeev Vibhakar, Lola B. Chambless, Michael K. Cooper, Reid C. Thompson, Claudia C. Faria, Alice Carvalho, Sofia Nunes, José Pimentel, Xing Fan, Karin M. Muraszko, Enrique López-Aguilar, David Lyden, Livia Garzia, David J. H. Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A. Northcott, Marcel Kool, David T. W. Jones, Jennifer A. Chan, Ana Nikolic, Maria Luisa Garre, Erwin G. Van Meir, Satoru Osuka, Jeffrey J. Olson, Arman Jahangiri, Brandyn A. Castro, Nalin Gupta, William A. Weiss, Iska Moxon-Emre, Donald J. Mabbott, Alvaro Lassaletta, Cynthia E. Hawkins, Uri Tabori, James Drake, Abhaya Kulkarni, Peter Dirks, James T. Rutka, Andrey Korshunov, Stefan M. Pfister, Roger J. Packer, Vijay Ramaswamy, Michael D. Taylor
Dátum:
2016
ISSN:
1470-2045
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Lancet Oncology 17 : 4 (2016), p. 484-495. -
További szerzők:
Hielscher, Thomas
Bouffet, Eric
Remke, Marc
Luu, Betty
Gururangan, Sridharan
McLendon, Roger E.
Bigner, Darell
Lipp, Eric S.
Perreault, Sebastien
Cho, Yoon-Jae
Grant, Gerald
Kim, Seung-Ki
Lee, Ji-Yeoun
Rao, Amulya A. Nageswara
Giannini, Caterina
Li, Kay Ka Wai
Ng, Ho-Keung
Yao, Yu
Kumabe, Toshihiro
Tominaga, Teiji
Grajkowska, Wieslawa A.
Perek-Polnik, Marta
Low, David C.Y.
Seow, Wan Tew
Chang, Kenneth T.E.
Mora, Jaume
Pollack, Ian F.
Hamilton, Ronald L.
Leary, Sarah
Moore, Andrew S.
Ingram, Wendy J.
Hallahan, Andrew R.
Jouvet, Anne
Fèvre-Montange, Michelle
Vasiljevic, Alexandre
Faure-Conter, Cecile
Shofuda, Tomoko
Kagawa, Naoki
Hashimoto, Naoya
Jabado, Nada
Weil, Alexander G.
Gayden, Tenzin
Wataya, Takafumi
Shalaby, Tarek
Grotzer, Michael
Zitterbart, Karel
Sterba, Jaroslav
Kren, Leos
Hortobágyi Tibor (1965-) (patológus)
Klekner Álmos (1970-) (idegsebész)
Bognár László (1958-) (idegsebész, gyermekidegsebész)
Pócza Tímea
Hauser Péter
Schüller, Ulrich
Jung, Shin
Jang, Woo-Youl
French, Pim J.
Kros, Johan M.
van Veelen, Marie-Lise C.
Massimi, Luca
Leonard, Jeffrey R.
Rubin, Joshua B.
Vibhakar, Rajeev
Chambless, Lola B.
Cooper, Michael K.
Thompson, Reid C.
Faria, Claudia C.
Carvalho, Alice
Nunes, Sofia
Pimentel, José
Fan, Xing
Muraszko, Karin M.
Lopez-Aguilar, Enrique
Lyden, David
Garzia, Livia
Shih, David J. H.
Kijima, Noriyuki
Schneider, Christian
Adamski, Jennifer
Northcott, Paul A.
Kool, Marcel
Jones, David T. W.
Chan, Jennifer A.
Nikolic, Ana
Garre, Maria Luisa
van Meir, Erwin G.
Osuka, Satoru
Olson, Jeffrey J.
Jahangiri, Arman
Castro, Brandyn A.
Gupta, Nalin
Weiss, William A.
Moxon-Emre, Iska
Mabbott, Donald J.
Lassaletta, Alvaro
Hawkins, Cynthia E.
Tabori, Uri
Drake, James
Kulkarni, Abhaya
Dirks, Peter
Rutka, James T.
Korshunov, Andrey
Pfister, Stefan M.
Packer, Roger J.
Ramaswamy, Vijay
Taylor, Michael D.
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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Saját polcon:
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