Találati lista | Tudóstér

001-es BibID:	BIBFORM052712
Első szerző:	Kleinman, Claudia L.
Cím:	Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR / Claudia L. Kleinman, Noha Gerges, Simon Papillon-Cavanagh, Patrick Sin-Chan, Albena Pramatarova, Dong-Anh Khuong Quang, Véronique Adoue, Stephan Busche, Maxime Caron, Haig Djambazian, Amandine Bemmo, Adam M. Fontebasso, Tara Spence, Jeremy Schwartzentruber, Steffen Albrecht, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Jose-Luis Montes, Alfredo Staffa, Alexandre Montpetit, Pierre Berube, Magdalena Zakrzewska, Krzysztof Zakrzewski, Pawel P. Liberski, Zhifeng Dong, Peter M. Siegel, Thomas Duchaine, Christian Perotti, Adam Fleming, Damien Faury, Marc Remke, Marco Gallo, Peter Dirks Michael D. Taylor, Robert Sladek, Tomi Pastinen, Jennifer A. Chan, Annie Huang, Jacek Majewski, Nada Jabado
Dátum:	2013
ISSN:	1061-4036
Megjegyzések:	Embryonal tumors with multilayered rosettes (ETMRs) are rare, deadly pediatric brain tumors characterized by high-level amplification of the microRNA cluster C19MC1, 2. We performed integrated genetic and epigenetic analyses of 12 ETMR samples and identified, in all cases, C19MC fusions to TTYH1 driving expression of the microRNAs. ETMR tumors, cell lines and xenografts showed a specific DNA methylation pattern distinct from those of other tumors and normal tissues. We detected extreme overexpression of a previously uncharacterized isoform of DNMT3B originating at an alternative promoter3 that is active only in the first weeks of neural tube development. Transcriptional and immunohistochemical analyses suggest that C19MC-dependent DNMT3B deregulation is mediated by RBL2, a known repressor of DNMT3B4, 5. Transfection with individual C19MC microRNAs resulted in DNMT3B upregulation and RBL2 downregulation in cultured cells. Our data suggest a potential oncogenic re-engagement of an early developmental program in ETMR via epigenetic alteration mediated by an embryonic, brain-specific DNMT3B isoform.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Nature Genetics. - 46 : 1 (2013), p. 39-44. -
További szerzők:	Gerges, Noha Papillon-Cavanagh, Simon Sin-Chan, Patrick Pramatarova, Albena Quang, Dong-Anh Khuong Adoue, Véronique Busche, Stephan Caron, Maxime Djambazian, Haig Bemmo, Amandine Fontebasso, Adam M. Spence, Tara Schwartzentruber, Jeremy Albrecht, Stephen Hauser Péter Garami Miklós Klekner Álmos (1970-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Montes, Jose-Luis Staffa, Alfredo Montpetit, Alexandre Berube, Pierre Zakrzewska, Magdalena Zakrzewski, Krzystof Liberski, Pawel P. Dong, Zhifeng Siegel, Peter Duchaine, Thomas Perotti, Christian Fleming, Adam Faury, Damien Remke, Marc Gallo, Marco Dirks, Peter Taylor, Michael D. Sladek, Robert Pastinen, Tomi Chan, Jennifer A. Huang, Annie Majewski, Jacek Jabado, Nada
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM066682
Első szerző:	Torchia, Jonathon
Cím:	Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors / Torchia Jonathon, Golbourn Brian, Feng Shengrui, Ho King Ching, Sin-Chan Patrick, Vasiljevic Alexandre, Norman Joseph D., Guilhamon Paul, Garzia Livia, Agamez Natalia R., Lu Mei, Chan Tiffany S. Y., Picard Daniel, de Antonellis Pasqualino, Khuong-Quang Dong-Anh, Planello Aline C., Zeller Constanze, Barsyte-Lovejoy Dalia, Lafay-Cousin Lucie, Letourneau Louis, Bourgey Mathieu, Yu Man, Gendoo Deena M. A., Dzamba Misko, Barszczyk Mark, Medina Tiago, Riemenschneider Alexandra N., Morrissy A. Sorana, Ra Young-Shin, Ramaswamy Vijay, Remke Marc, Dunham Christopher P., Yip Stephen, Ng Ho-keung, Lu Jian-Qiang, Mehta Vivek, Albrecht Steffen, Pimentel Jose, Chan Jennifer A., Somers Gino R., Faria Claudia C., Roque Lucia, Fouladi Maryam, Hoffman Lindsey M., Moore Andrew S., Wang Yin, Choi Seung Ah, Hansford Jordan R., Catchpoole Daniel, Birks Diane K., Foreman Nicholas K., Strother Doug, Klekner Almos, Bognár Laszló, Garami Miklós, Hauser Péter, Hortobágyi Tibor, Wilson Beverly, Hukin Juliette, Carret Anne-Sophie, Van Meter Timothy E., Hwang Eugene I., Gajjar Amar, Chiou Shih-Hwa, Nakamura Hideo, Toledano Helen, Fried Iris, Fults Daniel, Wataya Takafumi, Fryer Chris, Eisenstat David D., Scheineman Katrin, Fleming Adam J., Johnston Donna L., Michaud Jean, Zelcer Shayna, Hammond Robert, Afzal Samina, Ramsay David A., Sirachainan Nongnuch, Hongeng Suradej, Larbcharoensub Noppadol, Grundy Richard G., Lulla Rishi R., Fangusaro Jason R., Druker Harriet, Bartels Ute, Grant Ronald, Malkin David, McGlade C. Jane, Nicolaides Theodore, Tihan Tarik, Phillips Joanna, Majewski Jacek, Montpetit Alexandre, Bourque Guillaume, Bader Gary D., Reddy Alyssa T., Gillespie G. Yancey, Warmuth-Metz Monika, Rutkowski Stefan, Tabori Uri, Lupien Mathieu, Brudno Michael, Schüller Ulrich, Pietsch Torsten, Judkins Alexander R., Hawkins Cynthia E., Bouffet Eric, Kim Seung-Ki, Dirks Peter B., Taylor Michael D., Erdreich-Epstein Anat, Arrowsmith Cheryl H., De Carvalho Daniel D., Rutka James T., Jabado Nada, Huang Annie
Dátum:	2016
ISSN:	1535-6108
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Cancer Cell 30 : 6 (2016), p. 891-908. -
További szerzők:	Golbourn, Brian Feng, Shengrui Ho, King Ching Sin-Chan, Patrick Vasiljevic, Alexandre Norman, Joseph D. Guilhamon, Paul Garzia, Livia Agamez, Natalia R. Lu, Mei Chan, Tiffany Sin Yu Picard, Daniel De Antonellis, Pasqualino Khuong-Quang, Dong-Anh Planello, Aline C. Zeller, Constanze Barsyte-Lovejoy, Dalia Lafay-Cousin, Lucie Letourneau, Louis Bourgey, Mathieu Yu, Man Gendoo, Deena M. A. Dzamba, Misko Barszczyk, Mark Medina, Tiago Riemenschneider, Alexandra N. Morrissy, Sorana Ra, Young-Shin Ramaswamy, Vijay Remke, Marc Dunham, Christopher P. Yip, Stephen Ng, Ho-Keung Lu, Jian-Qiang Mehta, Vivek Albrecht, Stephen Pimentel, José Chan, Jennifer A. Somers, Gino R. Faria, Claudia C. Roque, Lucia Fouladi, Maryam Hoffman, Lindsey M. Moore, Andrew S. Wang, Yin Choi, Seung Ah Hansford, Jordan R. Catchpoole, Daniel Birks, Diane Foreman, Nicholas K. Strother, Douglas Klekner Álmos (1970-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Garami Miklós Hauser Péter Hortobágyi Tibor (1965-) (patológus) Wilson, Beverly Hukin, Juliette Carret, Anne-Sophie van Meter, Timothy E. Hwang, Eugene Gajjar, Amar Chiou, Shih-Hwa Nakamura, Hideo Toledano, Helen Fried, Iris Fults, Daniel Wataya, Takafumi Fryer, Chris Eisenstat, David D. Scheineman, Katrin Fleming, Adam Johnston, Donna Michaud, Jean Zelcer, Shayna Hammond, Robert Afzal, Samina Ramsay, David A. Sirachainan, Nongnuch Hongeng, Suradej Larbcharoensub, Noppadol Grundy, Richard G. Lulla, Rishi R. Fangusaro, Jason R. Druker, Harriet Bartels, Ute Grant, Ronald Malkin, David McGlade, C. Jane Nicolaides, Theodore Tihan, Tarik Phillips, Joanna J. Majewski, Jacek Montpetit, Alexandre Bourque, Guillaume Bader, Gary D. Reddy, Alyssa T. Gillespie, G. Yancey Warmuth-Metz, Monika Rutkowski, Stefan Tabori, Uri Lupien, Mathieu Brudno, Michael Schüller, Ulrich Pietsch, Torsten Judkins, Alexander R. Hawkins, Cynthia E. Bouffet, Eric Kim, Seung-Ki Dirks, Peter Taylor, Michael D. Erdreich-Epstein, Anat Arrowsmith, Cheryl H. De Carvalho, Daniel D. Rutka, James T. Jabado, Nada Huang, Annie
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM063337
Első szerző:	Torchia, Jonathon
Cím:	Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis / Jonathon Torchia, Daniel Picard, Lucie Lafay-Cousin, Cynthia E. Hawkins, Seung-Ki Kim, Louis Letourneau, Young-Shin Ra, King Ching Ho, Tiffany Sin Yu Chan, Patrick Sin-Chan, Christopher P. Dunham, Stephen Yip, Ho-Keung Ng, Jian-Qiang Lu, Steffen Albrecht, José Pimentel, Jennifer A. Chan, Gino R. Somers, Maria Zielenska, Claudia C. Faria, Lucia Roque, Berivan Baskin, Diane Birks, Nick Foreman, Douglas Strother, Almos Klekner, Miklos Garami, Peter Hauser, Tibor Hortobágyi, Laszló Bognár, Beverly Wilson, Juliette Hukin, Anne-Sophie Carret, Timothy E. Van Meter, Hideo Nakamura, Helen Toledano, Iris Fried, Daniel Fults, Takafumi Wataya, Chris Fryer, David D. Eisenstat, Katrin Scheineman, Donna Johnston, Jean Michaud, Shayna Zelcer, Robert Hammond, David A. Ramsay, Adam J. Fleming, Rishi R. Lulla, Jason R. Fangusaro, Nongnuch Sirachainan, Noppadol Larbcharoensub, Suradej Hongeng, Muhammad Abrar Barakzai, Alexandre Montpetit, Derek Stephens, Richard G. Grundy, Ulrich Schüller, Theodore Nicolaides, Tarik Tihan, Joanna Phillips, Michael D. Taylor, James T. Rutka, Peter Dirks, Gary D. Bader, Monika Warmuth-Metz, Stefan Rutkowski, Torsten Pietsch, Alexander R. Judkins, Nada Jabado, Eric Bouffet, Annie Huang
Dátum:	2015
ISSN:	1470-2045
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Lancet Oncology. - 16 : 5 (2015), p. 569-582. -
További szerzők:	Picard, Daniel Lafay-Cousin, Lucie Hawkins, Cynthia E. Kim, Seung-Ki Letourneau, Louis Ra, Young-Shin Ho, King Ching Chan, Tiffany Sin Yu Sin-Chan, Patrick Dunham, Christopher P. Yip, Stephen Ng, Ho-Keung Lu, Jian-Qiang Albrecht, Stephen Pimentel, José Chan, Jennifer A. Somers, Gino R. Zielenska, Maria Faria, Claudia C. Roque, Lucia Baskin, Berivan Birks, Diane Foreman, Nicholas K. Strother, Douglas Klekner Álmos (1970-) (idegsebész) Garami Miklós Hauser Péter Hortobágyi Tibor (1965-) (patológus) Bognár László (1958-) (idegsebész, gyermekidegsebész) Wilson, Beverly Hukin, Juliette Carret, Anne-Sophie van Meter, Timothy E. Nakamura, Hideo Toledano, Helen Fried, Iris Fults, Daniel Wataya, Takafumi Fryer, Chris Eisenstat, David D. Scheineman, Katrin Johnston, Donna Michaud, Jean Zelcer, Shayna Hammond, Robert Ramsay, David A. Fleming, Adam Lulla, Rishi R. Fangusaro, Jason R. Sirachainan, Nongnuch Larbcharoensub, Noppadol Hongeng, Suradej Barakzai, Muhammad Abrar Montpetit, Alexandre Stephens, Derek Grundy, Richard G. Schüller, Ulrich Nicolaides, Theodore Tihan, Tarik Phillips, Joanna J. Taylor, Michael D. Rutka, James T. Dirks, Peter Bader, Gary D. Warmuth-Metz, Monika Rutkowski, Stefan Pietsch, Torsten Judkins, Alexander R. Jabado, Nada Bouffet, Eric Huang, Annie
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: