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1.
001-es BibID:
BIBFORM077121
Első szerző:
Cavalli, Florence M. G.
Cím:
Heterogeneity within the PF-EPN-B ependymoma subgroup / Florence M. G. Cavalli, Jens-Martin Hübner, Tanvi Sharma, Betty Luu, Martin Sill, Michal Zapotocky, Stephen C. Mack, Hendrik Witt, Tong Lin, David J. H. Shih, Ben Ho, Mariarita Santi, Lyndsey Emery, Juliette Hukin, Christopher Dunham, Roger E. McLendon, Eric S. Lipp, Sridharan Gururangan, Andrew Grossbach, Pim French, Johan M. Kros, Marie-Lise C. van Veelen, Amulya A. Nageswara Rao, Caterina Giannini, Sarah Leary, Shin Jung, Claudia C. Faria, Jaume Mora, Ulrich Schüller, Marta M. Alonso, Jennifer A. Chan, Almos Klekner, Lola B. Chambless, Eugene I. Hwang, Maura Massimino, Charles G. Eberhart, Matthias A. Karajannis, Benjamin Lu, Linda M. Liau, Massimo Zollo, Veronica Ferrucci, Carlos Carlotti, Daniela P. C. Tirapelli, Uri Tabori, Eric Bouffet, Marina Ryzhova, David W. Ellison, Thomas E. Merchant, Mark R. Gilbert, Terri S. Armstrong, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor, Kenneth Aldape, Kristian W. Pajtler, Marcel Kool, Vijay Ramaswamy
Dátum:
2018
Megjegyzések:
Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. To discern the molecular heterogeneity within PFB, we performed an integrated analysis consisting of DNA methylation profiling, copy-number profiling, gene expression profiling, and clinical correlation across a cohort of 212 primary posterior fossa PFB tumors. Unsupervised spectral clustering and t-SNE analysis of genome-wide methylation data revealed five distinct subtypes of PFB tumors, termed PFB1-5, with distinct demographics, copy-number alterations, and gene expression profiles. All PFB subtypes were distinct from PFA and posterior fossa subependymomas. Of the five subtypes, PFB4 and PFB5 are more discrete, consisting of younger and older patients, respectively, with a strong female-gender enrichment in PFB5 (age: p = 0.011, gender: p = 0.04). Broad copy-number aberrations were common; however, many events such as chromosome 2 loss, 5 gain, and 17 loss were enriched in specific subtypes and 1q gain was enriched in PFB1. Late relapses were common across all five subtypes, but deaths were uncommon and present in only two subtypes (PFB1 and PFB3). Unlike the case in PFA ependymoma, 1q gain was not a robust marker of poor progression-free survival; however, chromosome 13q loss may represent a novel marker for risk stratification across the spectrum of PFB subtypes. Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified. Even when accounting for this heterogeneity, extent of resection remains the strongest predictor of poor outcome. However, this biological heterogeneity must be accounted for in future preclinical modeling and personalized therapies.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Acta Neuropathologica. - 136 : 2 (2018), p. 227-237. -
További szerzők:
Hübner, Jens-Martin
Sharma, Tanvy
Luu, Betty
Sill, Martin
Zapotocky, Michal
Mack, Stephen
Witt, Hendrik
Lin, Tong
Shih, David J. H.
Ho, Ben
Santi, Mariarita
Emery, Lyndsey
Hukin, Juliette
Dunham, Christopher P.
McLendon, Roger E.
Lipp, Eric S.
Gururangan, Sridharan
Grossbach, Andrew
French, Pim J.
Kros, Johan M.
van Veelen, Marie-Lise C.
Rao, Amulya A. Nageswara
Giannini, Caterina
Leary, Sarah
Jung, Shin
Faria, Claudia C.
Mora, Jaume
Schüller, Ulrich
Alonso, Marta M.
Chan, Jennifer A.
Klekner Álmos (1970-) (idegsebész)
Chambless, Lola B.
Hwang, Eugene
Massimino, Maura
Eberhart, Charles G.
Karajannis, Matthias A.
Lu, Benjamin
Liau, Linda M.
Zollo, Massimo
Ferrucci, Veronica
Carlotti, Carlos G.
Tirapelli, Daniela P. C.
Tabori, Uri
Bouffet, Eric
Ryzhova, Marina
Ellison, David W.
Merchant, Thomas E.
Gilbert, Mark R.
Armstrong, Terri S.
Korshunov, Andrey
Pfister, Stefan M.
Taylor, Michael D.
Aldape, Kenneth
Pajtler, Kristian W.
Kool, Marcel
Ramaswamy, Vijay
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM063631
Első szerző:
Ramaswamy, Vijay
Cím:
Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era : a retrospective multicohort analysis / Vijay Ramaswamy, Thomas Hielscher, Stephen C. Mack, Alvaro Lassaletta, Tong Lin, Kristian W. Pajtler, David T. W. Jones, Betty Luu, Florence M. G. Cavalli, Kenneth Aldape, Marc Remke, Martin Mynarek, Stefan Rutkowski, Sridharan Gururangan, Roger E. McLendon, Eric S. Lipp, Christopher Dunham, Juliette Hukin, David D. Eisenstat, Dorcas Fulton, Frank K.H. van Landeghem, Mariarita Santi, Marie-Lise C. van Veelen, Erwin G. Van Meir, Satoru Osuka, Xing Fan, Karin M. Muraszko, Daniela P. C. Tirapelli, Sueli M. Oba-Shinjo, Suely K. N. Marie, Carlos G. Carlotti, Ji Yeoun Lee, Amulya A. Nageswara Rao, Caterina Giannini, Claudia C. Faria, Sofia Nunes, Jaume Mora, Ronald L. Hamilton, Peter Hauser, Nada Jabado, Kevin Petrecca, Shin Jung, Luca Massimi, Massimo Zollo, Giuseppe Cinalli, Bognár László, Almos Klekner, Tibor Hortobágyi, Sarah Leary, Ralph P. Ermoian, James M. Olson, Jeffrey R. Leonard, Corrine Gardner, Wieslawa A. Grajkowska, Lola B. Chambless, Jason Cain, Charles G. Eberhart, Sama Ahsan, Maura Massimino, Felice Giangaspero, Francesca R. Buttarelli, Roger J. Packer, Lyndsey Emery, William H. Yong, Horacio Soto, Linda M. Liau, Richard Everson, Andrew Grossbach, Tarek Shalaby, Michael Grotzer, Matthias A. Karajannis, David Zagzag, Helen Wheeler, Katja von Hoff, Marta M. Alonso, Teresa Tunon, Ulrich Schüller, Karel Zitterbart, Jaroslav Sterba, Jennifer A. Chan, Miguel Guzman, Samer K. Elbabaa, Howard Colman, Girish Dhall, Paul G. Fisher, Maryam Fouladi, Amar Gajjar, Stewart Goldman, Eugene Hwang, Marcel Kool, Harshad Ladha, Elizabeth Vera-Bolanos, Khalida Wani, Frank Lieberman, Tom Mikkelsen, Antonio M. Omuro, Ian F. Pollack, Michael Prados, H. Ian Robins, Riccardo Soffietti, Jing Wu, Phillipe Metellus, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, Stefan M. Pfister, Thomas E. Merchant, Mark R. Gilbert, Terri S. Armstrong, Andrey Korshunov, David W. Ellison, Michael D. Taylor
Dátum:
2016
ISSN:
0368-2811
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Journal Of Clinical Oncology. - 34 : 21 (2016), p. 2468-2477. -
További szerzők:
Hielscher, Thomas
Mack, Stephen
Lassaletta, Alvaro
Lin, Tong
Pajtler, Kristian W.
Jones, David T. W.
Luu, Betty
Cavalli, Florence M. G.
Aldape, Kenneth
Remke, Marc
Mynarek, Martin
Rutkowski, Stefan
Gururangan, Sridharan
McLendon, Roger E.
Lipp, Eric S.
Dunham, Christopher P.
Hukin, Juliette
Eisenstat, David D.
Fulton, Dorcas
van Landeghem, Frank K.H.
Santi, Mariarita
van Veelen, Marie-Lise C.
van Meir, Erwin G.
Osuka, Satoru
Fan, Xing
Muraszko, Karin M.
Tirapelli, Daniela P. C.
Oba-Shinjo, Sueli M.
Marie, Suely K. N.
Carlotti, Carlos G.
Lee, Ji-Yeoun
Rao, Amulya A. Nageswara
Giannini, Caterina
Faria, Claudia C.
Nunes, Sofia
Mora, Jaume
Hamilton, Ronald L.
Hauser Péter
Jabado, Nada
Petrecca, Kevin
Jung, Shin
Massimi, Luca
Zollo, Massimo
Cinalli, Giuseppe
Bognár László (1958-) (idegsebész, gyermekidegsebész)
Klekner Álmos (1970-) (idegsebész)
Hortobágyi Tibor (1965-) (patológus)
Leary, Sarah
Ermoian, Ralph P.
Olson, James M.
Leonard, Jeffrey R.
Gardner, Corrine
Grajkowska, Wieslawa A.
Chambless, Lola B.
Cain, Jason
Eberhart, Charles G.
Ahsan, Sama
Massimino, Maura
Giangaspero, Felice
Buttarelli, Francesca R.
Packer, Roger J.
Emery, Lyndsey
Yong, William H.
Soto, Horacio
Liau, Linda M.
Everson, Richard B.
Grossbach, Andrew
Shalaby, Tarek
Grotzer, Michael
Karajannis, Matthias A.
Zagzag, David
Wheeler, Helen
von Hoff, Katja
Alonso, Marta M.
Tunon, Teresa
Schüller, Ulrich
Zitterbart, Karel
Sterba, Jaroslav
Chan, Jennifer A.
Guzman, Miguel
Elbabaa, Samer K.
Colman, Howard
Dhall, Girish
Fisher, Paul G.
Fouladi, Maryam
Gajjar, Amar
Goldman, Stewart
Hwang, Eugene
Kool, Marcel
Ladha, Harshad
Vera-Bolanos, Elizabeth
Wani, Khalida
Lieberman, Frank
Mikkelsen, Tom
Omuro, Antonio M.
Pollack, Ian F.
Prados, Michael D.
Robins, H. Ian
Soffietti, Riccardo
Wu, Jing
Metellus, Phillipe
Tabori, Uri
Bartels, Ute
Bouffet, Eric
Hawkins, Cynthia E.
Rutka, James T.
Dirks, Peter
Pfister, Stefan M.
Merchant, Thomas E.
Gilbert, Mark R.
Armstrong, Terri S.
Korshunov, Andrey
Ellison, David W.
Taylor, Michael D.
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
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