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001-es BibID:BIBFORM077121
Első szerző:Cavalli, Florence M. G.
Cím:Heterogeneity within the PF-EPN-B ependymoma subgroup / Florence M. G. Cavalli, Jens-Martin Hübner, Tanvi Sharma, Betty Luu, Martin Sill, Michal Zapotocky, Stephen C. Mack, Hendrik Witt, Tong Lin, David J. H. Shih, Ben Ho, Mariarita Santi, Lyndsey Emery, Juliette Hukin, Christopher Dunham, Roger E. McLendon, Eric S. Lipp, Sridharan Gururangan, Andrew Grossbach, Pim French, Johan M. Kros, Marie-Lise C. van Veelen, Amulya A. Nageswara Rao, Caterina Giannini, Sarah Leary, Shin Jung, Claudia C. Faria, Jaume Mora, Ulrich Schüller, Marta M. Alonso, Jennifer A. Chan, Almos Klekner, Lola B. Chambless, Eugene I. Hwang, Maura Massimino, Charles G. Eberhart, Matthias A. Karajannis, Benjamin Lu, Linda M. Liau, Massimo Zollo, Veronica Ferrucci, Carlos Carlotti, Daniela P. C. Tirapelli, Uri Tabori, Eric Bouffet, Marina Ryzhova, David W. Ellison, Thomas E. Merchant, Mark R. Gilbert, Terri S. Armstrong, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor, Kenneth Aldape, Kristian W. Pajtler, Marcel Kool, Vijay Ramaswamy
Dátum:2018
Megjegyzések:Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. To discern the molecular heterogeneity within PFB, we performed an integrated analysis consisting of DNA methylation profiling, copy-number profiling, gene expression profiling, and clinical correlation across a cohort of 212 primary posterior fossa PFB tumors. Unsupervised spectral clustering and t-SNE analysis of genome-wide methylation data revealed five distinct subtypes of PFB tumors, termed PFB1-5, with distinct demographics, copy-number alterations, and gene expression profiles. All PFB subtypes were distinct from PFA and posterior fossa subependymomas. Of the five subtypes, PFB4 and PFB5 are more discrete, consisting of younger and older patients, respectively, with a strong female-gender enrichment in PFB5 (age: p = 0.011, gender: p = 0.04). Broad copy-number aberrations were common; however, many events such as chromosome 2 loss, 5 gain, and 17 loss were enriched in specific subtypes and 1q gain was enriched in PFB1. Late relapses were common across all five subtypes, but deaths were uncommon and present in only two subtypes (PFB1 and PFB3). Unlike the case in PFA ependymoma, 1q gain was not a robust marker of poor progression-free survival; however, chromosome 13q loss may represent a novel marker for risk stratification across the spectrum of PFB subtypes. Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified. Even when accounting for this heterogeneity, extent of resection remains the strongest predictor of poor outcome. However, this biological heterogeneity must be accounted for in future preclinical modeling and personalized therapies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Neuropathologica. - 136 : 2 (2018), p. 227-237. -
További szerzők:Hübner, Jens-Martin Sharma, Tanvy Luu, Betty Sill, Martin Zapotocky, Michal Mack, Stephen Witt, Hendrik Lin, Tong Shih, David J. H. Ho, Ben Santi, Mariarita Emery, Lyndsey Hukin, Juliette Dunham, Christopher P. McLendon, Roger E. Lipp, Eric S. Gururangan, Sridharan Grossbach, Andrew French, Pim J. Kros, Johan M. van Veelen, Marie-Lise C. Rao, Amulya A. Nageswara Giannini, Caterina Leary, Sarah Jung, Shin Faria, Claudia C. Mora, Jaume Schüller, Ulrich Alonso, Marta M. Chan, Jennifer A. Klekner Álmos (1970-) (idegsebész) Chambless, Lola B. Hwang, Eugene Massimino, Maura Eberhart, Charles G. Karajannis, Matthias A. Lu, Benjamin Liau, Linda M. Zollo, Massimo Ferrucci, Veronica Carlotti, Carlos G. Tirapelli, Daniela P. C. Tabori, Uri Bouffet, Eric Ryzhova, Marina Ellison, David W. Merchant, Thomas E. Gilbert, Mark R. Armstrong, Terri S. Korshunov, Andrey Pfister, Stefan M. Taylor, Michael D. Aldape, Kenneth Pajtler, Kristian W. Kool, Marcel Ramaswamy, Vijay
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001-es BibID:BIBFORM063631
Első szerző:Ramaswamy, Vijay
Cím:Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era : a retrospective multicohort analysis / Vijay Ramaswamy, Thomas Hielscher, Stephen C. Mack, Alvaro Lassaletta, Tong Lin, Kristian W. Pajtler, David T. W. Jones, Betty Luu, Florence M. G. Cavalli, Kenneth Aldape, Marc Remke, Martin Mynarek, Stefan Rutkowski, Sridharan Gururangan, Roger E. McLendon, Eric S. Lipp, Christopher Dunham, Juliette Hukin, David D. Eisenstat, Dorcas Fulton, Frank K.H. van Landeghem, Mariarita Santi, Marie-Lise C. van Veelen, Erwin G. Van Meir, Satoru Osuka, Xing Fan, Karin M. Muraszko, Daniela P. C. Tirapelli, Sueli M. Oba-Shinjo, Suely K. N. Marie, Carlos G. Carlotti, Ji Yeoun Lee, Amulya A. Nageswara Rao, Caterina Giannini, Claudia C. Faria, Sofia Nunes, Jaume Mora, Ronald L. Hamilton, Peter Hauser, Nada Jabado, Kevin Petrecca, Shin Jung, Luca Massimi, Massimo Zollo, Giuseppe Cinalli, Bognár László, Almos Klekner, Tibor Hortobágyi, Sarah Leary, Ralph P. Ermoian, James M. Olson, Jeffrey R. Leonard, Corrine Gardner, Wieslawa A. Grajkowska, Lola B. Chambless, Jason Cain, Charles G. Eberhart, Sama Ahsan, Maura Massimino, Felice Giangaspero, Francesca R. Buttarelli, Roger J. Packer, Lyndsey Emery, William H. Yong, Horacio Soto, Linda M. Liau, Richard Everson, Andrew Grossbach, Tarek Shalaby, Michael Grotzer, Matthias A. Karajannis, David Zagzag, Helen Wheeler, Katja von Hoff, Marta M. Alonso, Teresa Tunon, Ulrich Schüller, Karel Zitterbart, Jaroslav Sterba, Jennifer A. Chan, Miguel Guzman, Samer K. Elbabaa, Howard Colman, Girish Dhall, Paul G. Fisher, Maryam Fouladi, Amar Gajjar, Stewart Goldman, Eugene Hwang, Marcel Kool, Harshad Ladha, Elizabeth Vera-Bolanos, Khalida Wani, Frank Lieberman, Tom Mikkelsen, Antonio M. Omuro, Ian F. Pollack, Michael Prados, H. Ian Robins, Riccardo Soffietti, Jing Wu, Phillipe Metellus, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, Stefan M. Pfister, Thomas E. Merchant, Mark R. Gilbert, Terri S. Armstrong, Andrey Korshunov, David W. Ellison, Michael D. Taylor
Dátum:2016
ISSN:0368-2811
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Clinical Oncology. - 34 : 21 (2016), p. 2468-2477. -
További szerzők:Hielscher, Thomas Mack, Stephen Lassaletta, Alvaro Lin, Tong Pajtler, Kristian W. Jones, David T. W. Luu, Betty Cavalli, Florence M. G. Aldape, Kenneth Remke, Marc Mynarek, Martin Rutkowski, Stefan Gururangan, Sridharan McLendon, Roger E. Lipp, Eric S. Dunham, Christopher P. Hukin, Juliette Eisenstat, David D. Fulton, Dorcas van Landeghem, Frank K.H. Santi, Mariarita van Veelen, Marie-Lise C. van Meir, Erwin G. Osuka, Satoru Fan, Xing Muraszko, Karin M. Tirapelli, Daniela P. C. Oba-Shinjo, Sueli M. Marie, Suely K. N. Carlotti, Carlos G. Lee, Ji-Yeoun Rao, Amulya A. Nageswara Giannini, Caterina Faria, Claudia C. Nunes, Sofia Mora, Jaume Hamilton, Ronald L. Hauser Péter Jabado, Nada Petrecca, Kevin Jung, Shin Massimi, Luca Zollo, Massimo Cinalli, Giuseppe Bognár László (1958-) (idegsebész, gyermekidegsebész) Klekner Álmos (1970-) (idegsebész) Hortobágyi Tibor (1965-) (patológus) Leary, Sarah Ermoian, Ralph P. Olson, James M. Leonard, Jeffrey R. Gardner, Corrine Grajkowska, Wieslawa A. Chambless, Lola B. Cain, Jason Eberhart, Charles G. Ahsan, Sama Massimino, Maura Giangaspero, Felice Buttarelli, Francesca R. Packer, Roger J. Emery, Lyndsey Yong, William H. Soto, Horacio Liau, Linda M. Everson, Richard B. Grossbach, Andrew Shalaby, Tarek Grotzer, Michael Karajannis, Matthias A. Zagzag, David Wheeler, Helen von Hoff, Katja Alonso, Marta M. Tunon, Teresa Schüller, Ulrich Zitterbart, Karel Sterba, Jaroslav Chan, Jennifer A. Guzman, Miguel Elbabaa, Samer K. Colman, Howard Dhall, Girish Fisher, Paul G. Fouladi, Maryam Gajjar, Amar Goldman, Stewart Hwang, Eugene Kool, Marcel Ladha, Harshad Vera-Bolanos, Elizabeth Wani, Khalida Lieberman, Frank Mikkelsen, Tom Omuro, Antonio M. Pollack, Ian F. Prados, Michael D. Robins, H. Ian Soffietti, Riccardo Wu, Jing Metellus, Phillipe Tabori, Uri Bartels, Ute Bouffet, Eric Hawkins, Cynthia E. Rutka, James T. Dirks, Peter Pfister, Stefan M. Merchant, Thomas E. Gilbert, Mark R. Armstrong, Terri S. Korshunov, Andrey Ellison, David W. Taylor, Michael D.
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