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001-es BibID:BIBFORM041999
Első szerző:Ernestus, Ralf-Ingo
Cím:Polyamine metabolism in brain tumours : diagnostic relevance of quantitative biochemistry / Ernestus, R. I., Röhn, G., Schröder, R., Els, T., Klekner, Á., Paschen, W., Klug, N.
Dátum:2001
ISSN:0022-3050
Megjegyzések:OBJECTIVE: Activation of polyamine metabolism is closely associated with cellular proliferation. The purpose was to investigate whether the content of the polyamines putrescine, spermidine, and spermine, and the activity of the first metabolic key enzyme of polyamine metabolism, ornithine decarboxylase (ODC), represent biochemical markers of malignancy in brain tumours. METHODS: The concentration of putrescine, spermidine, and spermine, and the activity of ODC were biochemically quantified in tissue samples obtained during open microsurgery of 670 patients with brain tumours. Biochemical analysis and histopathological classification were carried out in serial tumour samples. RESULTS: The activity of ODC was very low in peritumoral non-neoplastic brain tissue (0.9 (SD 0.6) nmol/g/h). It was significantly higher in gliomas and it significantly increased with a higher grade of malignancy (grade I 2.7 (2.8) nmol/g/h, grade II 3.1 (4.0) nmol/g/h, grade III 5.7 (5.6) nmol/g/h, grade IV 10.6 (11.7) nmol/g/h). High enzyme activity was also found in medulloblastomas (25.5 (15.1) nmol/g/h), malignant lymphomas (52.1 (42.1) nmol/g/h), and metastases from carcinoma (14.9 (22.1) nmol/g/h). Lowest values were measured in epidermoid cysts (0.5 (0.2) nmol/g/h), craniopharyngiomas (1.2 (0.9) nmol/g/h), angioblastomas (1.6 (1.7) nmol/g/h), and neurinomas (2.0 (1.8) nmol/g/h). By contrast with ODC activity, polyamine concentrations did not correlate with the grade of malignancy. Correlation of regional biochemical and histomorphological data in rapidly growing neoplasms showed high enzyme activity in solid tumour parts and low activity in necrotic areas. CONCLUSIONS: Novel data relating ODC activation and polyamine concentrations to neuropathology is presented indicating that high ODC activity represents a biochemical marker of malignancy in brain tumours. This information is important for clinical and therapeutic investigations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurology Neurosurgery And Psychiatry. - 71 : 1 (2001), p. 88-92. -
További szerzők:Röhn Gabriella Schröder, Roland Els, T. Klekner Álmos (1970-) (idegsebész) Paschen, Wulf Klug, Norfrid
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001-es BibID:BIBFORM040000
Első szerző:Klekner Álmos (idegsebész)
Cím:ODC mRNA as a prognostic factor for recurrence in meningiomas / Klekner, Á., Röhn, G., Schillinger, G., Schröder, R., Klug, N., Ernestus, R. I.
Dátum:2001
ISSN:0167-594X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 53 : 1 (2001), p. 67-75. -
További szerzők:Röhn Gabriella Schillinger, Gerhard Schröder, Roland Klug, Norfrid Ernestus, Ralf-Ingo
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