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001-es BibID:	BIBFORM067748
Első szerző:	Kappos, Ludwig
Cím:	The 11-year long-term follow-up study from the randomized BENEFIT CIS trial / Ludwig Kappos, Gilles Edan, Mark S. Freedman, Xavier Montalbán, Hans-Peter Hartung, Bernhard Hemmer, Edward J. Fox, Frederik Barkhof, Sven Schippling, Andrea Schulze, Dirk Pleimes, Christoph Pohl, Rupert Sandbrink, Gustavo Suarez, Eva-Maria Wicklein, BENEFIT Study Group
Dátum:	2016
ISSN:	0028-3878
Megjegyzések:	Objective: To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or after a short delay.Methods: Participants in BENEFIT (Betaferon/Betaseron in Newly Emerging MS for Initial Treatment) were randomly assigned to receive interferon beta-1b (early treatment) or placebo (delayed treatment). After conversion to clinically definite multiple sclerosis (CDMS) or 2 years, patients on placebo could switch to interferon beta-1b or another treatment. Eleven years after randomization, patients were reassessed.Results: Two hundred seventy-eight (59.4%) of the original 468 patients (71.3% of those eligible atparticipating sites) were enrolled (early: 167 [57.2%]; delayed: 111 [63.1%]). After 11 years, risk of CDMS remained lower in the early-treatment arm compared with the delayed-treatment arm (p 50.0012), with longer time to first relapse (median [Q1, Q3] days: 1,888 [540, not reached] vs 931 [253, 3,296]; p50.0005) and lower overall annualized relapse rate (0.21 vs 0.26; p50.0018). Only25 patients (5.9%, overall; early, 4.5%; delayed, 8.3%) converted to secondary progressive multiple sclerosis. Expanded Disability Status Scale scores remained low and stable, with no differencebetween treatment arms (median [Q1,Q3]: 2.0 [1.0, 3.0]). The early-treatment group had better Paced Auditory Serial Addition Task?3 total scores (p 5 0.0070). Employment rates remained high, and health resource utilization tended to be low in both groups.MRI metrics did not differ between groups.Conclusions: Although the delay in treatment was relatively short, several clinical outcomes favored earlier treatment. Along with low rates of disability and disease progression in bothgroups, this supports the value of treatment at CIS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neurology 87 : 10 (2016), p. 978-987. -
További szerzők:	Edan, Gilles Freedman, Mark S. Montalbán, Xavier Hartung, Hans-Peter Hemmer, Bernhard Fox, Edward J. Barkhof, Frederik Schippling, Sven Schulze, Andrea Pleimes, Dirk Pohl, Christoph Sandbrink, Rupert Suarez, Gustavo Wicklein, Eva-Maria Csiba László (1952-) (neurológus, pszichiáter) Csépány Tünde (1956-) (neurológus, pszichiáter) BENEFIT Study Group
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001-es BibID:	BIBFORM067750
Első szerző:	Kovács Katalin T. (orvos, Pécs)
Cím:	Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus : a preliminary study / Katalin T. Kovacs, Sudhakar R. Kalluri, Antonio Boza-Serrano, Tomas Deierborg, Tunde Csepany, Magdolna Simo, Laszlo Rokusz, Attila Miseta, Nicolas Alcaraz, Laszlo Czirjak, Timea Berki, Tihamer Molnar, Bernhard Hemmer, Zsolt Illes
Dátum:	2016
Megjegyzések:	Background: Neuromyelitis optica (NMO)?systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies.Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute.Methods: In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and antidsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission.Results: AQP4-IgG1 was present 1?2?5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-?,interferon-gamma-induced CCL10/IP-10 and CCL17/TARC (p<0.05, respectively). CCL17/TARC correlated with levels of anti-nucleosome and anti-dsDNA (p<0.05, respectively). Compared to healthy subjects, concentration of IFN-? and CCL17/TARC was higher in NMO/SLE (p<0.05).Conclusions: AQP4-IgG1 antibodies are present in the sera years before the first NMO attack in patients with SLE; elevation of anti-AQP4 is part of a polyclonal B cell response during NMO relapses; in spite of multiple autoantibodies in the serum, MOG antibodies were not present; Th1 responses accompany autoantibody responses in NMO/SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban AQP4 SLE myelin oligodendrocyte glycoprotein IL-17 IP-10 Th1 Th17
Megjelenés:	Multiple Sclerosis Journal 22 : 9 (2016), p. 1192-1201. -
További szerzők:	Kalluri, Sudhakar Reddy Boza-Serrano, Antonio Deierborg, Tomas Csépány Tünde (1956-) (neurológus, pszichiáter) Simó Magdolna Rókusz László Miseta Attila Alcaraz, Nicolas Czirják László Berki Tímea Molnár Tihamér (1992-) (általános orvos) Hemmer, Bernhard Illés Zsolt (neurológus, Pécs)
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001-es BibID:	BIBFORM085750
Első szerző:	Nielsen, Helle H.
Cím:	Integrin and IL-16/IL-23 biomarker clusters differentiate AQP4-IgG+ NMO spectrum disorders, relapsing-remitting MS and healthy controls / H. H. Nielsen, S. Kalluri, T. Frisch, T. Sejbaek, G. Dale, T. Petersen, Csépány Tünde, Lovas Gábor, M. Simo, P. Diószeghy, J. Baumbach, B. Hemmer, Z. Illes
Dátum:	2017
ISSN:	1352-4585
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Multiple Sclerosis. - 23 (2017), p. 685. -
További szerzők:	Kalluri, Sudhakar Reddy Frisch, T. Sejbaek, Tobias Dale, George L. Petersen, Thor Csépány Tünde (1956-) (neurológus, pszichiáter) Lovas Gábor Simó Magdolna Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Baumbach, J. Hemmer, Bernhard Illés Zsolt (neurológus, Pécs)
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