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001-es BibID:	BIBFORM103013
035-os BibID:	(Wos)000597939700001 (Scopus)85097297540
Első szerző:	Berger, Thomas
Cím:	Factors influencing daily treatment choices in multiple sclerosis : practice guidelines, biomarkers and burden of disease / Berger Thomas, Adamczyk-Sowa Monika, Csépány Tünde, Fazekas Franz, Fabjan Tanja Hojs, Horáková Dana, Ledinek Alenka Horvath, Illes Zsolt, Kobelt Gisela, Jazbec Sasa Sega, Klímová Eleonóra, Leutmezer Fritz, Rejdak Konrad, Rozsa Csilla, Sellner Johann, Selmaj Krzysztof, Stourac Pavel, Szilasiová Jarmila, Turcáni Peter, Vachová Marta, Vanecková Manuela, Vécsei László, Havrdová Eva Kubala
Dátum:	2020
ISSN:	1756-2856 1756-2864
Megjegyzések:	At two meetings of a Central European board of multiple sclerosis (MS) experts in 2018 and 2019 factors influencing daily treatment choices in MS, especially practice guidelines, biomarkers and burden of disease, were discussed. The heterogeneity of MS and the complexity of the available treatment options call for informed treatment choices. However, evidence from clinical trials is generally lacking, particularly regarding sequencing, switches and escalation of drugs. Also, there is a need to identify patients who require highly efficacious treatment from the onset of their disease to prevent deterioration. The recently published European Committee for the Treatment and Research in Multiple Sclerosis/European Academy of Neurology clinical practice guidelines on pharmacological management of MS cover aspects such as treatment efficacy, response criteria, strategies to address suboptimal response and safety concerns and are based on expert consensus statements. However, the recommendations constitute an excellent framework that should be adapted to local regulations, MS center capacities and infrastructure. Further, available and emerging biomarkers for treatment guidance were discussed. Magnetic resonance imaging parameters are deemed most reliable at present, even though complex assessment including clinical evaluation and laboratory parameters besides imaging is necessary in clinical routine. Neurofilament-light chain levels appear to represent the current most promising non-imaging biomarker. Other immunological data, including issues of immunosenescence, will play an increasingly important role for future treatment algorithms. Cognitive impairment has been recognized as a major contribution to MS disease burden. Regular evaluation of cognitive function is recommended in MS patients, although no specific disease-modifying treatment has been defined to date. Finally, systematic documentation of real-life data is recognized as a great opportunity to tackle unresolved daily routine challenges, such as use of sequential therapies, but requires joint efforts across clinics, governments and pharmaceutical companies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Therapeutic Advances in Neurological Disorders. - 13 (2020), p. 1-13. -
További szerzők:	Adamczyk-Sowa, Monika Csépány Tünde (1956-) (neurológus, pszichiáter) Fazekas, Franz Fabjan, Tanja Hojs Horakova, Dana Horváth Ledinek, Alenka Illés Zsolt (neurológus, Pécs) Kobelt, Gisela Jazbec, Sasa Sega Klimova, Eleonora Leutmezer, Fritz Rejdak, Konrad Rózsa Csilla Sellner, Johann Selmaj, Krzysztof Stourac, Pavel Szilasiova, Jarmila Turčáni, Peter Vachova Márta Vanecková, Manuela Vécsei László (1954-) (neurológus) Havrdova, Eva
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