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1.

001-es BibID:BIBFORM029949
Első szerző:Bereczki Dániel (neurológus)
Cím:Stroke Units in Hungary : The Debrecen Experience / Bereczki D., Csiba L., Fülesdi B., Fekete I.
Dátum:2003
ISSN:1015-9770
Megjegyzések:The Debrecen Stroke Unit covers a catchment area of 210,000 inhabitants in eastern Hungary. The unit was established at the Department of Neurology of the University Hospital in 1974 and has 23 beds, 7 of which have monitoring facilities. The unit treats about 600 patients with acute cerebrovascular diseases annually - about 60% of all hospitalised stroke cases in the region. Overall, 18 registered nurses and 4 nurse helpers work for the unit. Computer tomography is performed in over 90% of cases. Carotid duplex ultrasound and echocardiography are part of the routine examinations in ischaemic strokes. Delay from onset of stroke to hospital arrival is the main barrier against the use of rt-PA. Average length of stay is 12 days; a lack of rehabilitation and nursing capacities sometimes delays discharge of dependent patients. The hospital is reimbursed the costs of stroke care based on DRG.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular Diseases. - 15 : Suppl. 1 (2003), p. 23-25. -
További szerzők:Csiba László (1952-) (neurológus, pszichiáter) Fülesdi Béla (1961-) (aneszteziológus) Fekete István (1951-) (neurológus, pszichiáter)
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2.

001-es BibID:BIBFORM029943
Első szerző:Bessenyei Mónika (neurológus, csecsemő- és gyermekgyógyász)
Cím:Characteristics of 4 stroke scales for the detection of changes in clinical signs in the acute phase of stroke / Bessenyei, M., Fekete, I., Csiba, L., Bereczki, D.
Dátum:2001
ISSN:1052-3057
Megjegyzések:OBJECTIVES: Detection of minor changes in clinical signs of stroke may be of interest when evaluating treatment interventions. This study analyzes the internal structure of four frequently used stroke scales and compares them for their sensitivity to detect changes in neurologic signs in the first week after acute stroke.METHODS:A cohort of 77 hospitalized acute stroke patients was scored by the Mathew, the National Institutes of Health (NIH), the Scandinavian, and the Orgogozo scales within 48 hours of hospital admission and again 7 days later.RESULTS:Scores on different scales correlated well with each other (range of absolute value of Spearman R, .82-.91; P <.001 in all comparisons). Scales reflected significant changes from entry to reexamination: P = .0013 for the Scandinavian scale (P = .004 for prognostic and P = .009 for long-term items, respectively); P = .00009 for the Orgogozo scale; P = .000007 for the Mathew scale; and P < .000001 for the NIH scale. This difference in sensitivity coincided with the number of factors extracted by principal component analysis: higher sensitivity of a scale was associated with a larger number of factors. Initial scores differed significantly among patients who were discharged, patients who died, and patients who remained hospitalized 7 days after the first examination (Kruskal-Wallis ANOVA, P < .01 for all scales).CONCLUSIONS:There are considerable differences in the internal structure of the different scales as reflected by the different number of factors extracted from the scale items. The application of the NIH scale is recommended for the most sensitive detection of changes in stroke signs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Stroke and Cerebrovascular Diseases. - 10 : 2 (2001), p. 70-78. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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3.

001-es BibID:BIBFORM045970
Első szerző:Bogousslavsky, Julien
Cím:The Mannheim Declaration of Stroke in Eastern Europe : accepted at the 13th European Stroke Conference, Mannheim-Heidelberg, Germany, May 12-15, 2004 / J. Bogousslavsky, M. G. Hennerici, M. Kaste, L. Csiba, M. Brainin, D. Bereczki, Z. Nagy, A. Czlonkowska, V. Demarin, J. Pascu, V. I. Skvortsova, E. Ehler
Dátum:2004
ISSN:1015-9770
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztőségi anyag
Megjelenés:Cerebrovascular Diseases. - 18 : 3 (2004), p. 248-248. -
További szerzők:Hennerici, M. Kaste, M. Csiba László (1952-) (neurológus, pszichiáter) Brainin, Michael Bereczki Dániel (1960-) (neurológus) Nagy Zoltán (1942-) (neurológus) Czlonkowska, A. Demarin, Vida Pascu, J. Skvortsova, Veronica I. Ehler, E.
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4.

001-es BibID:BIBFORM079825
Első szerző:Fekete Klára (neurológus)
Cím:Experiences with intravenous (IV) and intraarterial (IA) thrombolysis in Debrecen, Hungary, focused on glucose level at admission and patients over 80 / K. Fekete, D. Bereczki, L. Csiba, I. Fekete
Dátum:2010
ISSN:1015-9770
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:Cerebrovascular Diseases. - 29 : 2 (2010), p. 1-361. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter)
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5.

001-es BibID:BIBFORM079826
Első szerző:Fekete Klára (neurológus)
Cím:Alcohol consumption and smoking are associated with higher 30-day case fatality after stroke in the mures-uzhgorod-debrecen (mud) database / K. E. Fekete, S. Szatmári, I. Szőcs, C. Szekeres, J. Szász, L. Mihálka, V. Smolanka, L. Csiba, D. Bereczki
Dátum:2008
ISSN:1015-9770
Megjegyzések:Abstract Introduction: Age, alcohol consumption, smoking are important risk factors of stroke. After stroke most of the patients suffer from different grade of disability. Methods: In this work the risk factors, mentioned above, the disability and the 30 day case fatality was investigated by analyzing the data of 1047 patients from the MUD database between the 1 st of October 1999 and 30th of September 2000. (The distribution of the patients in the database is the following: 554 patients in Debrecen, 260 patients in Targu Mures and 233 in Uzhgorod). Results: The distribution of stroke concerning the genders by our database is the following: 42,5% female, 57,5 % male. Before discharge 222 patients (22,1%) died. By 172 of the patients (16,4%) occurred stroke in the familial-history. The ratio of the age was found more unfavorable by males: between 30 and 60 years the frequency of stroke was twice as high as by females (on the average by 30,75% of women and 69,26% of men suffer stroke).The ratio is very similar by cerebral bleeding not only ischemia. 249 of total stroke patients admitted alcohol consumption (23,8%), 551 did not (52,6%) (28,6%is unknown). The 30 day mortality rate was 25,3% between the patients admitting alcohol consumption, and only 9,3% between those who did not. In total 339 patients suffered cerebral bleeding ( 32,4%), which is higher then the literary dates. No difference was found between the 3 examination places. The ratio of death in the group of alcohol consumers and alcohol-non-consumer was equally prominently high without any difference. In our database 25,09% of the patients smoked. The excess of disability at dismission was analyzed by 825 patients with the following results: 153 patients (18,5%) needed permanent care, 182 (22%) patients needed help by every-day-life, 230 (27,5%) patients could live a self-sufficient life with residual signs, and 260 (31,5%) had no neurological sign. Results and conclusion: The analysis of the MUD database emphasizes the medical education of the population in health policy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:Cerebrovascular Diseases. - 25 : 2 (2008), p. 71. -
További szerzők:Szatmári Szabolcs (1960-) (neurológus) Szőcs Ildikó (1970-) (orvos) Szekeres Csilla Cecília (1980-) (orvos) Szász József (1960-) (neurológus) Mihálka László (1950-) (neurológus) Smolanka, Volodymyr I. (1950-) (orvos) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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6.

001-es BibID:BIBFORM062617
Első szerző:Fekete Klára (neurológus)
Cím:Predictors of Long-term Outcome after Intravenous or Intra-arterial Recombinant Tissue Plasminogen Activator Treatment in the Eastern Hungarian Thrombolysis Database / Klára Fekete, Sándor Márton, Judit Tóth, László Csiba, István Fekete, Dániel Bereczki
Dátum:2015
ISSN:1052-3057 1532-8511
Megjegyzések:Background: This prospective single-center study aimed to identify features determininglong-term outcome after thrombolysis in a Central European stroke population.Methods: Between 1 January, 2004, and 31 December, 2010, 415 patients weretreated with recombinant tissue plasminogen activator at the Department ofNeurology, University of Debrecen. Stroke severity by the National Institute ofHealth Stroke Scale score (NIHSSS) and imaging findings by the Alberta Stroke ProgrammeEarly Computed Tomography score (ASPECTS) were evaluated on admissionand 1 day later. The modified Rankin Scale (mRS) at 3 months and case fatalityat 1 year were evaluated. Independent predictors of outcome were identified bymultivariate testing. Results: Data of 369 patients were analyzed. Median NIHSSSwas 12 (interquartile range [IQR], 8-17) on admission and 10 (IQR, 5-16) at 24 hours.Arterial occlusion was found in 55%. Symptomatic intracerebral hemorrhage (SICH)was detected in 3.8%. Outcome was significantly worse, and SICH was morefrequent in intra-arterially treated patients. At 3 months, one third of the patientswere independent (mRS #2), and 23% were dead. At 1 year 2 of 3 patients were alive.Significant independent predictors of disability at 3 months were 24-hour NIHSSS,admission ASPECTS, admission glucose level, and treatment modality. Only the24-hour NIHSSS was a significant predictor of case fatality at 1 year. Conclusions:Although short-term outcome was similar, the 3-month and 1-year outcomes wereworse than data from previous reports. A more efficient health care program shouldbe implemented after stroke to maintain the favorable effect of thrombolysis in thelong term.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischemic stroke
thrombolysis
predictors
outcome
Megjelenés:Journal Of Stroke And Cerebrovascular Diseases. - 24 : 1 (2015), p. 117-124. -
További szerzők:Márton Sándor (szociológus) Tóth Judit Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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7.

001-es BibID:BIBFORM049525
Első szerző:Fekete Klára (neurológus)
Cím:Prestroke Alcohol Consumption and Smoking Are Not Associated with Stroke Severity, Disability at Discharge, and Case Fatality / Klára Fekete, Szabolcs Szatmári, Ildikó Szőcs, Csilla Szekeres, József Szász, László Mihálka, Volodymyr Smolanka, László Kardos, László Csiba, Dániel Bereczki
Dátum:2014
Megjegyzések:Background: Heavy alcohol consumption and smoking are known risk factors for stroke but their influence on stroke severity and outcome may also be important. We tested if alcohol consumption and smoking relate to initial stroke severity, disability at discharge from hospital and outcome at 30 days and at 1 year in 1049 patients of the Mures-Uzhgorod-Debrecen database. Methods: Initial stroke severity was scored by the NIH stroke scale. Case fatality and the modified outcome scale of the 1st International Stroke Trial were used to assess outcome. We used multiple regression analysis.Results: Before their stroke, 24.5% were smokers and 24.7 % admitted regular alcohol consumption. Neither smoking nor alcohol consumption status were associated with initial stroke severity. Case fatality at discharge, at 30 days and at 1 year were 12.2%, 16.9% and 28.3%, respectively. Initial stroke severity, hemorrhagic subtype, and age in men over 60 years were strong predictors of outcome. We did not find significant difference among alcohol consumers and non-consumers in 30-day and in one year case fatality in all stroke patients and in ischemic stroke patients. In hemorrhagic stroke, there was a non-significant tendency for higher case fatality among alcohol-consumers (39.5% vs. 26.4%, p>0.2 at 30 days and 48.8% vs. 35.8%, p>0.2 at 1 year). Smoking did not influence significantly the outcome at 30-days and at one-year.Conclusion: despite being risk factors, pre-stroke smoking and alcohol consumption do not have a significant influence on stroke severity and on short- and long- term outcome.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alcohol, smoking and stroke severity
Megjelenés:Journal of Stroke and Cerebrovascular Diseases. - 23 : 1 (2014), p. e31-e37. -
További szerzők:Szatmári Szabolcs (1960-) (neurológus) Szőcs Ildikó (1970-) (orvos) Szekeres Csilla Cecília (1980-) (orvos) Szász József (1960-) (neurológus) Mihálka László (1950-) (neurológus) Smolanka, Volodymyr I. (1950-) (orvos) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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8.

001-es BibID:BIBFORM004806
Első szerző:Harangi Mariann (belgyógyász, endokrinológus)
Cím:Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease / Mariann Harangi, Ildiko Seres, Maria T. Magyar, Istvan Csipo, Sandor Sipka, Attila Valikovics, Laszlo Csiba, Daniel Bereczki, Gyorgy Paragh
Dátum:2008
Megjegyzések:Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. Methods: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intimamedia thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. Results: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between saltstimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. Conclusion: The importance of PON1 activity as a redictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Paraoxonase
Intima-media thickness
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular Diseases 25 : 1-2 (2008), p. 122-128. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Magyar Mária Tünde (1970-) (neurológus) Csípő István (1953-) (vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Paragh György (1953-) (belgyógyász)
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9.

001-es BibID:BIBFORM029925
035-os BibID:PMID:9684064
Első szerző:Kappelmayer János (laboratóriumi szakorvos)
Cím:Monocytes express tissue factor in young patients with cerebral ischemia / Kappelmayer, J., Bereczki, D., Misz, M., Oláh L., Fekete, I., Csiba, L., Blaskó, Gy.
Dátum:1998
ISSN:1015-9770
Megjegyzések:Activation of blood coagulation and fibrinolysis has previously been detected in stroke patients. It is unknown, however, what factors contribute to the acceleration of coagulation reactions, especially in cases where no obvious predisposing factors exist. We therefore postulated and tested the hypothesis that in such patients monocytes may trigger the pathway leading to thrombosis by expressing tissue factor (TF). TF antigen was determined in 48 patients and 40 controls by flow cytometry using an indirect immunofluorescent technique. TF antigen expression was significantly increased on monocytes in young stroke patients in both the acute (p < 0.01) and chronic (p < 0.05) phases of the disease. The TF antigen also possessed functional activity, quantitated by a one-stage clotting assay. TF expression on monocytes was not associated with an elevation in C-reactive protein values. In both acute and chronic phases, blood coagulation activation markers, e.g. the thrombin-antithrombin complex and F1 + 2 fragments, were significantly elevated. However, in the acute phase D-dimer levels were similar to those in controls and were only elevated in the chronic phase of the disease (p < 0.05). In conclusion, in cerebral ischemia TF expression on monocytes suggests enhanced activation of blood coagulation and subsequent fibrinolysis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular Diseases. - 8 : 4 (1998), p. 235-239. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Misz Mária Oláh László (1967-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Blaskó György (1947-) (belgyógyász, klinikai farmakológus)
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10.

001-es BibID:BIBFORM029269
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Transcranial Doppler monitoring in hypertensive patients during physical exercise / Magyar, M. T., Valikovics, A., Bereczki, D., Ficzere, A., Czuriga, I., Csiba, L.
Dátum:2001
ISSN:1015-9770
Megjegyzések:To evaluate the diagnostic value of a combined method, i.e. ergometer cycling with continuous bilateral transcranial Doppler monitoring (TCD) to detect cerebral hemodynamic abnormalities in recently diagnosed hypertensive patients. METHODS: 30 neurologically symptom-free, nontreated patients with essential hypertension and 30 age- and sex-matched controls were studied. Carotid ultrasound, resting ECG and blood parameters were investigated. Cycling ergometry was performed according to the WHO protocol. Blood pressure, heart rate, end-tidal CO2 (etCO2) and bilateral middle cerebral artery (MCA) blood flow velocity (MV) were monitored. RESULTS: At rest, MV in the MCA did not differ significantly between controls and hypertensive subjects. MV continuously increased in controls until the end of loading whereas a plateau was reached at 4 min in hypertensive subjects. During 6 min of cycling, the time course of absolute values of MV in the MCA and that of the changes in the ratio of mean velocity/end-tidal CO2 (DeltaMV/DeltaetCO2) differed significantly between hypertensive subjects and controls (p = 0.03 and p = 0.02, respectively). CONCLUSION: Ergometer cycling combined with TCD revealed altered vasoreactivity, therefore this may be a sensitive method for the detection of early hemodynamic impairment in nontreated hypertensive subjects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular diseases. - 12 : 3 (2001), p. 186-191. -
További szerzők:Valikovics Attila Bereczki Dániel (1960-) (neurológus) Ficzere Andrea (1967-) (neurológus) Czuriga István (1948-2018) (kardiológus) Csiba László (1952-) (neurológus, pszichiáter)
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11.

001-es BibID:BIBFORM029941
Első szerző:Oláh László (neurológus)
Cím:Natural coagulation inhibitor proteins in young patients with cerebral ischemia / Olah, L., Misz, M., Kappelmayer, J., Ajzner, E., Csepany, T., Fekete, I., Bereczki, D., Blasko, G., Csiba, L.
Dátum:2001
ISSN:1015-9770
Megjegyzések:Disturbances of coagulation and fibrinolytic pathways were studied in 53 young patients with cerebral ischemia. Upon admission 26 of 53 patients had abnormality in at least one of the antithrombin-III, protein C, protein S activities or in activated protein C (APC) ratios. Three months after the first examination the majority of the previously detected abnormalities returned to normal values and the most frequent alterations were decrease in protein S activity (3 patients) and APC resistance (3 patients). Conditions resulting in impaired fibrinolysis were frequently detected upon admission. Elevation of plasminogen activator inhibitor-1, lipoprotein (a), and alpha-2-antiplasmin was present in 23, 10, and 4 cases, respectively. It is concluded that abnormalities of coagulation as well as of the fibrinolytic systems are prevalent in the acute phase of cerebral ischemia, however, the results may be significantly influenced by the disease process or the acute phase effect.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular Diseases. - 12 : 4 (2001), p. 291-297. -
További szerzők:Misz Mária Kappelmayer János (1960-) (laboratóriumi szakorvos) Ajzner Éva (1968-) (laboratóriumi szakorvos) Csépány Tünde (1956-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Blaskó György (1947-) (belgyógyász, klinikai farmakológus) Csiba László (1952-) (neurológus, pszichiáter)
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12.

001-es BibID:BIBFORM025364
Első szerző:Páll Dénes (belgyógyász, kardiológus)
Cím:Increased common carotid artery intima media thickness in adolescent hypertension : results from the Debrecen Hypertension study / Dénes Páll, Georgios Settakis, Éva Katona, László Csiba, György Kakuk, Martien Limburg, Dániel Bereczki, Béla Fülesdi
Dátum:2003
Megjegyzések:The aim of the present work was to investigate intima media thickness (IMT) in healthy and in hypertensive adolescents and its influencing factors. METHODS: 103 hypertensive and 58 healthy adolescents were studied. IMT was measured in the common carotid artery using B-mode ultrasonography. Additionally, laboratory parameters (blood glucose, cholesterol, triglycerides, HDL- and LDL-cholesterols) and left ventricular mass indices were obtained. RESULTS: IMT in the common carotid artery was higher in hypertensive adolescents (means +/- SD: 0.55 +/- 0.11 mm) than in healthy control subjects (0.48 +/- 0.08 mm, p < 0.001). Similarly, a higher left ventricular mass index was measured in hypertensive (103.2 +/- 30.6 g/m(2)) than in healthy teenagers (91.1 +/- 25.2 g/m(2), p < 0.001). In general, IMT in adolescents was associated with age, weight, body mass index, left ventricular mass index and average systolic and diastolic blood pressure values of the subjects. By assessing the multivariate association between IMT and other factors, intima-media thickness was only associated with age and left ventricular mass index of the hypertensive subjects and was independent from all the investigated factors in normotensive controls. CONCLUSIONS: Our data suggest an ongoing target-organ damage in adolescent hypertension. These patients need to be subjected to early diagnostic methods, treatment and a regular follow-up, in order to avoid severe clinical manifestations of secondary target-organ damage due to hypertension.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular diseases. - 15 : 3 (2003), p. 167-172. -
További szerzők:Settakis, George Katona Éva (1967-) (belgyógyász, diabetológus) Csiba László (1952-) (neurológus, pszichiáter) Kakuk György (1938-2018) (belgyógyász) Limburg, Martien Bereczki Dániel (1960-) (neurológus) Fülesdi Béla (1961-) (aneszteziológus)
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