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1.

001-es BibID:BIBFORM022934
Első szerző:Garai Ildikó (radiológus)
Cím:Is the Tc-99m HMPAO appropriate for evaluation of muscle perfusion of the lower extremity? (Pilot study) / I. Garai, L. Galuska, L. Szabados, E. Szomják, S. Olvasztó, M. Kaplar, Z. Csiki, J. Varga
Dátum:2004
ISSN:1619-7070
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
is the Tc-99m HMPAO
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging. - 31 : 1 (2004), p. S438. -
További szerzők:Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Szabados Lajos (1977-) (orvos) Szomják Edit (1961-) (belgyógyász) Olvasztó Sándor (1957-) (sebész) Káplár Miklós (1965-) (belgyógyász, diabetológus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Varga József (1955-) (fizikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM010188
Első szerző:Káplár Miklós (belgyógyász, diabetológus)
Cím:Changes in cerebral blood flow detected by SPECT in type 1 and type 2 diabetic patients / Káplár Miklós, Paragh György, Erdei Annamária, Csongrádi Éva, Varga Éva, Garai Ildikó, Szabados Lajos, Galuska László, Varga József
Dátum:2009
ISSN:0161-5505 (Print)
Megjegyzések:Although macrovascular complications are typical for type 2 diabetes mellitus (T2DM), cerebral microvascular damage develops both in type 1 diabetes mellitus (T1DM) and T2DM. Color Doppler ultrasound is widely used for the examination of large- and medium-sized arteries, whereas SPECT and MRI are capable of identifying disturbances in the circulation of microvessels. Former studies using semiquantitative methods showed reduced reactivity and reserve capacity of cerebral vessels in both T1DM and T2DM patients. Our aim was to investigate whether there was any difference in the effects of the 2 types of diabetes mellitus on the global or regional cerebral blood flow, influenced by microvascular damage. METHODS: In our study, the circulation and reserve capacity of cerebral arteries was examined using (99m)Tc-hexamethylpropylene amine oxime SPECT. A total of 17 individuals with T1DM and 43 individuals with T2DM were involved in the study. RESULTS: Both basal and acetazolamide-challenged brain circulation were significantly lower in T2DM patients than in T1DM patients. We did not find a significant difference in the reserve capacity. However, the circulation of the frontal and occipital lobes changed differently in the 2 groups. The ratio of the circulation of the frontal and occipital lobes was significantly reduced both in basal and in acetazolamide-stimulated states in T2DM patients, independently of age (P < 0.0005 and P < 0.017), showing a greater relative decrease in the circulation of the frontal lobe in T2DM patients. CONCLUSION: There was a significant association between basal brain circulation and age, body mass index, and high-density lipoprotein (HDL), whereas acetazolamide-stimulated circulation showed a significant association with serum triglyceride and HDL.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Nuclear Medicine. - 50 : 12 (2009), p. 1993-1998. -
További szerzők:Paragh György (1953-) (belgyógyász) Erdei Annamária (1976-) (belgyógyász) Csongrádi Éva (1969-) (szakorvos) Varga Éva (1982-) (belgyógyász) Garai Ildikó (1966-) (radiológus) Szabados Lajos (1977-) (orvos) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Varga József (1955-) (fizikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM099030
035-os BibID:(Scopus)85122905153 (WOS)000754954100007
Első szerző:Képes Zita (orvos)
Cím:Homocysteine-related alterations of [18F]FDG brain pattern in metabolic diseases / Zita Képes, Csaba Aranyi, Attila Forgács, Ferenc Nagy, Kornél Kukuts, Regina Esze, Sándor Somodi, Miklós Káplár, József Varga, Miklós Emri, Ildikó Garai
Dátum:2021
ISSN:1790-5427
Megjegyzések:Since hyperhomocysteinaemia (HHcys) is implicated as a risk factor for the development of neurodegeneration, and is associated with the development of metabolic diseases, we aimed at analysing the effect of homocysteine (Hcys) on regional fluorine-18-fluorodeoxyglucose (18F-FDG) brain metabolism in 51 controlled type 2 diabetic and in 48 non-DM obese participants. Plasma Hcys levels were measured by an immunoassay. Homocysteine-related 18F-FDG regional brain metabolism was evaluated applying 18F-FDG PET/CT using magnetic resonance imaging (MRI)-based brain template for Statistical Parametric Mapping (SPM) analysis. Homocysteine-related decreased 18F-FDG uptake was shown in the right middle temporal gyrus in the whole population. Diabetics with Hcys above the reference limit expressed decreased glucose metabolism in the left calcarine cortex compared to the obese with HHcys. Regional metabolic alterations evoked on the basis of HHcys draw attention to the potential risk of neurodegeneration caused by metabolic disturbances.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Diabetes
Obesity
(18)-F-FDG PET/CT
Homocysteine
Neurodegeneration
Megjelenés:Hellenic Journal of Nuclear Medicine. - 24 : 3 (2021), p. 222-227. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM087278
035-os BibID:(WoS)000492444403175
Első szerző:Képes Zita (orvos)
Cím:Examinantion of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Zita Képes, J. Varga, F. Nagy, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: Microcircular alterations that could already be observed in prediabetic state (obesity and insulin resistance) are supposed to have significant role in the developement of the consequences of diabetes mellitus. The main aim of our study was to compare the cerebrovascular microcirculation and metabolism of obese patients and patients suffering from type 2 diabetes mellitus. Materials and Methods: In our prospective study 57 patients with controlled type 2 diabetes mellitus (52?9,6 years) and 46 obese patients (50,6?7,9 years) were enrolled. BMI proved to be 34,06?5,94 in the diabetic group while it was 38,14?6,06 among the obese patients. Dynamic Tc99m-HMPAO study (AnyScanFlex, Mediso) was performed for evaluation of hemispheral perfusion using Patlak analysis. Then tomographic imaging was carried out at rest condition. Brain metabolism was estimated applying 18F-FDG PET/CT (AnyScan PC, Mediso). FDG and HMPAO scans were transformed to MNI152 brain map after T1 registration and used for SPM (Statistical Parametric Mapping) analysis. NeuroQ application (Syntermed) was used to evaluate regional differences. Statistical analysis (Shapiro-Wilk, Wilcoxon, Spearman correlation) was applied for assessment of group differences. Results: Hemispheral perfusion calculated with Patlak analysis showed positive correlation with BMI (rho=0.35, p=0.016). There were no significant differences in hemispheral and regional perfusion in T2DM and the obese group. However, we found hypometabolism in right and left cuneus (Br17) in T2DM with SPM analysis. NeuroQ analysis did not reveal significant regional perfusion or metabolic defects in either groups. Conclusion: Based on current literature hypometabolism in the region of the cuneus is a characteristic feature of neurodegenerative diseases. The reason why no significant perfusion defects were found could be explained by the fact that the enrolled diabetics were therapeutically well managed. Unexpected significant correlation with BMI is unclear, further investigation is required. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S399-S400. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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5.

001-es BibID:BIBFORM087279
035-os BibID:(WoS)000492444401187
Első szerző:Mikó Márton
Cím:Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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6.

001-es BibID:BIBFORM022940
Első szerző:Varga József (fizikus)
Cím:Cerebral blood flow in types 1 and 2 of Diabetes / J. Varga, L. Szabados, A. Erdei, I. Garai, L. Galuska, M. Káplár
Dátum:2007
ISSN:1619-7070
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
cerebral blood
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal Of Nuclear Medicine And Molecular Imaging 34 : 2 (2007), p. S248. -
További szerzők:Szabados Lajos (1977-) (orvos) Erdei Annamária (1976-) (belgyógyász) Garai Ildikó (1966-) (radiológus) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Káplár Miklós (1965-) (belgyógyász, diabetológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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