CCL

Összesen 4 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM091895
Első szerző:Káplár Miklós (belgyógyász, diabetológus)
Cím:Az agyi és perifériás mikrocirkuláció, valamint az arteria carotis intima-media vastagság vizsgálata diabeteses betegekben és obezitásban / Káplár Miklós, Rajnai Liliána, Esze Regina, Képes Zita, Emri Miklós, Mikó Márton, Varga József, Somodi Sándor, Garai Ildikó
Dátum:2020
ISSN:1217-372X
Tárgyszavak:Orvostudományok Klinikai orvostudományok konferenciacikk
folyóiratcikk
Megjelenés:Diabetologia Hungarica. - 28 : Suppl1 (2020), p. 59-60. -
További szerzők:Rajnai Liliána Esze Regina Képes Zita (1991-) (orvos) Emri Miklós (1962-) (fizikus) Mikó Márton (1990-) Varga József (1955-) (fizikus) Somodi Sándor (1977-) (belgyógyász) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:2.1.1-15-2015-00609
GINOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM091839
Első szerző:Káplár Miklós (belgyógyász, diabetológus)
Cím:Alteration of cerebral and peripheral microcirculation in diabetes mellitus and obesity / Miklós Káplár, Zita Képes, Miklós Emri, Márton Mikó, József Varga, Sándor Somodi, Regina Esze, Liliana Rajnai, Ildikó Garai
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok nem besorolt
egyéb
További szerzők:Képes Zita (1991-) (orvos) Emri Miklós (1962-) (fizikus) Mikó Márton (1990-) Varga József (1955-) (fizikus) Somodi Sándor (1977-) (belgyógyász) Esze Regina Rajnai Liliána Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM098876
035-os BibID:(WoS)000730245900001 (Scopus)85121287053
Első szerző:Képes Zita (orvos)
Cím:Imaging with [99mTc]HMPAO - a novel perspective : investigation of [99mTc] HMPAO leg muscle uptake in metabolic diseases / Zita Képes, Márton Mikó, Kornél Kukuts, Regina Esze, Sándor Barna, Sándor Somodi, Miklós Káplár, József Varga, Ildikó Garai
Dátum:2023
ISSN:0284-1851
Megjegyzések:Background: Sensitive imaging modalities in the diagnosis of microcircular complications of the lower extremities induced by metabolic diseases are becoming a focus of interest. Purpose: To investigate the [99mTc]HMPAO uptake of the legs in type 2 diabetes mellitus (T2DM) and obesity, and to search for associations with clinical parameters and nerve conducting studies. Material and Methods: A total of 57 patients with controlled T2DM and 46 obese participants without DM were enrolled in the study. [99mTc]HMPAO SPECT/CT examinations were performed to evaluate the radiopharmaceutical accumulation of the legs. For the quantitative assessment of tracer uptake, standardized uptake value (SUVpeak) was measured in fixed spheric volumes of interest placed on both sural muscles on the attenuation-corrected images. Measurement of current perception threshold applying Neurometer (NM-01/CPT) was used to evaluate peripheral nerve dysfunction. Laboratory parameters assessing the glucose homeostasis of the study participants were also measured. Results: In the diabetic group, significantly lower leg SUV values were detected compared to the non-DM obese group (median: 0.517 vs. 0.607; P < 0.001). Body mass index (BMI) (P < 0.0001), age (P=0.0283), HbA1c (P =0.0068), and glucose level (P =0.0044) proved to be significant predictors of muscle tracer uptake. Neurometer studies showed positive correlation with HbA1c levels in the T2DM group (P=0.0002). Conclusion: We assume that [99mTc]HMPAO uptake of leg muscles is associated with microcirculation, so quantitative [99mTc]HMPAO SPECT/CT might be a sensitive method for evaluating lower limb microvascular alterations. BMI, age, HbA1c, and glucose level may be significant predictors of peripheral vascular abnormalities triggered by metabolic disturbances. Keywords: [99mTc]HMPAO, lower extremity, microcirculation, polyneuropathy, obesity, type 2 diabetes mellitus
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
[99mTc]HMPAO
lower extremity
microcirculation
polyneuropathy
obesity
type 2 diabetes mellitus
Megjelenés:Acta Radiologica. - 64 : 1 (2023), p. 187-194. -
További szerzők:Mikó Márton (1990-) Kukuts Kornél Esze Regina Barna Sándor (1982-) (kutató orvos) Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:2.1.1-15-2015-00609
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM087279
035-os BibID:(WoS)000492444401187
Első szerző:Mikó Márton
Cím:Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Rekordok letöltése1