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001-es BibID:	BIBFORM025492
Első szerző:	Páll Dénes (belgyógyász, kardiológus)
Cím:	Angiotensin-converting enzyme gene polymorphism, carotid intima-media thickness, and left ventricular mass index in adolescent hypertension / Dénes Páll, Georgios Settakis, Éva Katona, János Zatik, József Kollár, Martien Limburg, Béla Fülesdi
Dátum:	2004
Megjegyzések:	The aim of this study was to determine whether a positive correlation exists between the DD genotype of angiotensin-converting enzyme (ACE) and the carotid intima-media thickness (IMT) or left ventricular mass index (LVMI) in adolescents with hypertension. METHODS: We studied 120 hypertensive and 58 normotensive (control) adolescents. ACE gene polymorphism was determined by a standardized method. The IMT was measured in the common carotid arteries, and the LVMI was calculated on transthoracic echocardiography. The severity of hypertension was graded according to the results of ambulatory blood pressure monitoring as white coat, borderline, or proven hypertension. The association between ACE gene polymorphism and the obtained parameters was analyzed using analysis of variance and chi-square testing. RESULTS: Both the IMT and LVMI were higher in hypertensive than in control adolescents. In hypertensive subjects, no relationship was found between the different ACE genotypes and the IMT: the mean (+/- standard deviation) IMT in patients with the DD genotype was 0.57 +/- 0.11 mm; in those with the DI genotype, 0.53 +/- 0.01 mm; and in those with the II genotype, 0.55 +/- 0.01 mm. The LVMI was also similar in all 3 ACE genotypes: DD, 106.7 +/- 32.3 g/m(2); DI, 102.2 +/- 38.1 g/m(2); and II, 103.2 +/- 26.3 g/m(2). The severity of hypertension as assessed by ambulatory blood pressure monitoring was independent of the ACE genotype. CONCLUSIONS: Target-organ damage (left ventricular hypertrophy and carotid atherosclerosis) is detectable in adolescents with hypertension and, in those subjects, ACE genotype polymorphism is not correlated with the severity of target-organ damage as measured by IMT and LVMI.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of clinical ultrasound. - 32 : 3 (2004), p. 129-135. -
További szerzők:	Settakis, George Katona Éva (1967-) (belgyógyász, diabetológus) Zatik János (1961-) (szülész-nőgyógyász) Kollár József (1950-) (radiológus) Limburg, Martien Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM040094
Első szerző:	Zatik János (szülész-nőgyógyász)
Cím:	Assessment of cerebral hemodynamics during roll over test in healthy pregnant women and those with pre-eclampsia / Zatik, J., Major, T., Aranyosi, J., Molnár, Cs., Limburg, M., Fülesdi, B.
Dátum:	2001
ISSN:	1470-0328
Megjegyzések:	OBJECTIVE: To compare cerebral autoregulatory responses obtained during roll over tests in healthy pregnant women and those with pre-eclampsia in order to assess the middle cerebral artery velocity changes in relation to the roll over test in normotensive and pre-eclamptic women. PARTICIPANTS: Twenty-two healthy pregnant women and 26 with pre-eclampsia underwent transcranial Doppler measurements of the middle cerebral artery. METHODS: Systolic, mean and diastolic blood flow velocities and mean arterial blood pressures were recorded in the left lateral position and five minutes after turning to the supine position. Absolute values of mean blood flow velocities, mean arterial blood pressure values and calculated cerebral blood flow indices as well as cerebrovascular resistance area products were compared at different positions among the groups. RESULTS: Mean arterial blood pressure increased in both groups while turning from the left lateral to the supine position. In women with pre-eclampsia both mean arterial blood pressure and absolute values of mean blood flow velocity values were higher in both positions, compared with healthy pregnant women. In both groups, changing the position resulted in a decrease of absolute values of mean blood flow velocities. Calculated cerebral blood flow indices did not change, while cerebrovascular resistance area products increased significantly in the groups during roll over testing. In women with pre-eclampsia, the increase of cerebrovascular resistance area products was more pronounced as compared with healthy pregnant women. CONCLUSIONS: In women with pre-eclampsia roll over test results in an increase of the mean arterial blood pressure, which is accompanied by a decreased mean blood flow velocity in the middle cerebral artery. Further studies are needed to clarify the pathophysiological background of cerebral haemodynamic changes in pre-eclampsia.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal of Obstetrics and Gynaecology. - 108 : 4 (2001), p. 353-358. -
További szerzők:	Major Tamás (1963-) (szülész-nőgyógyász) Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Molnár Csilla (1962-) (aneszteziológus) Limburg, Martien Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM025361
Első szerző:	Zatik János (szülész-nőgyógyász)
Cím:	Breath holding test in preeclampsia : lack of evidence for altered cerebral vascular reactivity / Zatik J., Aranyosi J., Settakis G., Páll D., Tóth Z., Limburg M., Fülesdi B.
Dátum:	2002
Megjegyzések:	Twenty-five healthy and thirty-one preeclamptic pregnant women were assessed by means of transcranial Doppler sonography. Resting cerebral blood flow velocities in the middle cerebral arteries were measured followed by a repeat measurement 30 s after breath holding. Absolute blood flow velocities and per cent changes after breath holding procedure were compared between the groups. Absolute blood flow velocities were higher in preeclamptic pregnant women both at rest and after breath holding. The percent increase in cerebral blood flow velocity after breath holding (cerebral vascular reactivity) was similar in the two groups. Our data suggest that cerebral vascular reactivity is preserved in pregnant women with preeclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Journal of Obstetric Anesthesia. - 11 : 3 (2002), p. 160-163. -
További szerzők:	Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Settakis, George Páll Dénes (1967-) (belgyógyász, kardiológus) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Limburg, Martien Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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