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001-es BibID:BIBFORM093808
Első szerző:Juhász Marianna (aneszteziológus)
Cím:The effect of propofol-sufentanil intravenous anesthesia on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity : a case-series / Juhász Marianna, Páll Dénes, Fülesdi Béla, Molnár Levente, Végh Tamás, Molnár Csilla
Dátum:2021
ISSN:0104-0014
Megjegyzések:Background and objectives: The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO2-reactivity during propofol anesthesia. Methods: 27 patients undergoing general anesthesia were enrolled. Anesthesia was maintained using the Target-Controlled Infusion (TCI) method according to the Schnider model, effect site propofol concentration of 4 ?g.mL-1. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO2 for 5-minutes, respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded. Results: Systemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure did not change significantly during anesthetic induction and maintenance, whereas augmentation index as marker of arterial stiffness significantly decreased during the anesthetic induction and remained stable Journal Pre-proof at the time points when target CO2 levels were reached. Both cerebral autoregulation and cerebral CO2- reactivity was maintained during propofol anesthesia. Conclusions: Propofol at clinically administered doses using the Total Intravenous Anesthesia (TIVA/TCI) technique decreases systemic blood pressure, but does not affect static cerebral autoregulation, flow-metabolism coupling and cerebrovascular CO2 reactivity. According to our measurements, propofol may exert its systemic hemodynamic effect through venodilation. Trial registration: The study was registered at http://www.clinicaltrials.gov, identifier: NCT02203097, registration date: July 29, 2014.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
propofol
agyi vérátáramlás
cerebralis autoreguláció
CO2-reaktivitás
Applanációs tonometria
transcranialis Doppler
Megjelenés:Brazilian Journal of Anesthesiology (English Edition). - 71 : 5 (2021), p. 558-564. -
További szerzők:Páll Dénes (1967-) (belgyógyász, kardiológus) Fülesdi Béla (1961-) (aneszteziológus) Molnár Levente Végh Tamás (1975-) (aneszteziológus, intenzív terápiás szakorvos) Molnár Csilla (1962-) (aneszteziológus)
Pályázati támogatás:NAP II. 2017-1.2.1-NKP- 2017-00002
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001-es BibID:BIBFORM079331
Első szerző:Juhász Marianna (aneszteziológus)
Cím:Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity / Juhász Marianna, Molnár Levente, Fülesdi Béla, Végh Tamás, Páll Dénes, Molnár Csilla
Dátum:2019
ISSN:1471-2253
Megjegyzések:Background Sevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. However, there are no data how sevoflurane influences systemic and cerebral circulation in parallel. The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO2-reactivity during sevoflurane anesthesia. Methods Twenty nine patients undergoing general anesthesia were enrolled. Anesthesia was maintained with 1 MAC sevoflurane in 40% oxygen. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30?mmHg EtCO2 for 5?min respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded. Results Systemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure and augmentation index as markers of arterial stiffness significantly increased during the anesthetic induction and remained stable at the time points when target CO2 levels were reached. Both cerebral autoregulation and cerebral CO2-reactivity was maintained at 1 MAC sevoflurane. Discussion Cerebral autoregulation and CO2-reactivity is preserved at 1 MAC sevoflurane. Cerebrovascular effects of anesthetic compounds have to be assessed together with systemic circulatory effects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Sevoflurane
CO2-reactivity
applanation tonometry
Megjelenés:BMC Anesthesiology. - 19 : 1 (2019), p. 109-116. -
További szerzők:Molnár Levente Fülesdi Béla (1961-) (aneszteziológus) Végh Tamás (1975-) (aneszteziológus, intenzív terápiás szakorvos) Páll Dénes (1967-) (belgyógyász, kardiológus) Molnár Csilla (1962-) (aneszteziológus)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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