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1.

001-es BibID:BIBFORM071387
Első szerző:Harangi Mariann (belgyógyász, endokrinológus)
Cím:HDL subfraction distribution and HDL function in untreated dyslipidemic patients / Harangi Mariann, Szentpéteri Anita, Nádró Bíborka, Lőrincz Hajnalka, Seres Ildikó, Páll Dénes, Paragh György
Dátum:2017
ISSN:2574-1209
Megjegyzések:Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is wellknown. However, both structural and functional changes of the HDL particles may affect itsprotective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreasedHDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Somechanges in HDL subfraction distributions were also studied previously, but data on structuraland functional changes in dyslipidemia are not complete. Therefore, the authors aimed toevaluate these qualitative and quantitative markers of HDL in dyslipidemic patients andhealthy control subjects. Methods: Anthropometric parameters, serum levels of lipoproteinsand MPO, as well as PON1 activities were investigated in 81 untreated dyslipidemic patientsand in 32 healthy gender-matched controls. Additionally, HDL subfractions were detectedby an electrophoretic method on polyacrylamide gel (Lipoprint). Results: Significantlyhigher glucose, hemoglobin A1c, total cholesterol, low-density lipoprotein-cholesterol,triglyceride, lipoprotein(a), apolipoprotein B, C-reactive protein, and MPO levels were foundin patients compared to the healthy subjects. There were no significant differences in PON1paraoxonase and arylesterase activities between the two study groups, but MPO/PON1 ratiowas significantly higher in patients. There was a shift towards the smaller HDL subfractions,but only the intermediate HDL ratio was significantly lower in patients compared to controls.Conclusion: The results highlight the importance of HDL-associated pro- and antioxidantenzymes suggesting the possible clinical benefit of MPO/PON1 calculation and confirm thatquantification of HDL-C level alone provides limited data regarding HDL's cardioprotectiveeffect. Calculation of MPO/PON1 ratio may be a useful cardiovascular marker in dyslipidemia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
subfraction
paraoxonase
myeloperoxidase
dyslipidemia
high-density lipoprotein
Megjelenés:Vessel Plus. - 1 (2017), p. 166-173. -
További szerzők:Szentpéteri Anita (1988-) (biológus) Nádró Bíborka (1992-) (általános orvos) Lőrincz Hajnalka (1986-) (biológus) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00062
GINOP
OTKA-115723
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM042297
Első szerző:Koncsos Péter (belgyógyász)
Cím:Favorable effect of short-term lifestyle intervention on human paraoxonase-1 activity and adipokine levels in childhood obesity / Péter Koncsos, Ildikó Seres, Mariann Harangi, Dénes Páll, Lajos Józsa, László Bajnok, Endre V. Nagy, György Paragh
Dátum:2011
ISSN:0731-5724
Megjegyzések:The prevalence of obesity is increasing in adult and child populations throughout the world. Childhood obesity has a great impact on adult cardiovascular morbidity and mortality; treatment of this pathological state is important given the significant health consequences. We investigated the effect of short-term lifestyle changes on the alteration of human serum paraoxonase-1 (PON1) activities, leptin, adiponectin, E-selectin, and asymmetric dimethylarginine (ADMA) as atherogenic and antiatherogenic factors in obese children. PON1 protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low density lipoprotein (LDL) and therefore may protect against atherosclerosis. METHODS: A total of 23 white obese and overweight children (age, 11.43 ± 1.78 years; 8 girls, 15 boys) participated in a 2-week-long lifestyle camp based on a diet and exercise program. Overweight and obesity were defined according to the national body mass index (BMI) reference tables for age and sex. RESULTS: After a 2-week-long supervised diet and aerobic exercise program, obese children had significantly lower leptin (55.02 ± 33.42 ng/ml vs 25.37 ± 19.07 ng/ml; p < 0.0001), ADMA (0.68 ± 0.15 mikromol/l vs 0.55 ± 0.16 mikromol/l; p < 0.01), and E-selectin levels (67.19 ± 30.35 ng/ml vs 46.51 ± 18.40 ng/ml; p < 0.0001), whereas they had significantly higher PON1 paraoxonase activity (110.48 ± 72.92 U/l vs 121.75 ± 93.48 U/l; p < 0.05) besides the antiatherogenic alteration of the lipid profile and significant weight change (70.32 ± 19.51 kg vs 67.01 ± 18.75 kg, p < 0.0001; BMI, 28.95 ± 5.05 kg/m(2) vs 27.43 ± 4.82 kg/m(2), p < 0.0001). Adiponectin and PON1 arylesterase activity did not change significantly. CONCLUSIONS: Our investigation suggests that modifications in dietary habits and physical activity induce antiatherogenic changes in childhood obesity. These findings emphasize the major role of primary prevention and nonpharmaceutical treatment of childhood obesity through lifestyle changes based on diet and increased physical activity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Egészség- és Környezettudomány
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of the American College of Nutrition. - 30 : 5 (2011), p. 333-339. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Páll Dénes (1967-) (belgyógyász, kardiológus) Józsa Lajos Bajnok László (1961-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Gyulladásos és egyéb proatherogén tényezők vizsgálata a lipidanyagcsere zavarával járó kórállapotokban
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM103908
Első szerző:Nádró Bíborka (általános orvos)
Cím:Serum progranulin level in patients with newly diagnosed untreated familial hypercholesterolemia / Nádró B., Lőrincz H., Juhász L., Szentpéteri A., Sztanek F., Seres I., Páll D., Fülöp P., Paragh G., Harangi M.
Dátum:2022
ISSN:0021-9150
Megjegyzések:Background and Aims : Familial hypercholesterolemia (FH) is a monogenic form of severe hypercholesterolemia, characterized by elevated total cholesterol and low-density lipoprotein-cholesterol concentrations that, if left untreated, is associated with early onset of atherosclerosis. Progranulin (PGRN) is a recently discovered growth factor with many biological functions. PGRN has anti-inflammatory properties because it inhibits neutrophil degranulation and blocks tumor necrosis factor ? transmission, therefore, might be anti-atherogenic. To date, serum level of PGRN in patients with FH has not been studied. Methods: Eighty-one newly diagnosed, untreated patients with FH and 32 healthy control subjects were involved in our study. Serum PGRN levels were determined by ELISA. We diagnosed FH using the Dutch Lipid Clinic Network criteria. Results: We could not find significant difference in serum PGRN levels between FH patients and healthy controls (37.66?9.75 vs. 38.43?7.74 ng/mL, ns.). However, we found significant positive correlations between triglyceride, C-reactive protein (CRP), and PGRN levels (p<0.01 and p<0.01, respectively), while significant negative correlation was found between high-density lipoprotein cholesterol (HDL-C) and PGRN levels (p<0.05) both in the whole study population and in FH patients. Conclusions: Strong correlations between HDL-C, CRP and PGRN levels suggest that PGRN may exerts its anti-atherogenic effect in FH patients by alteration in HDL-C level by amelioration of inflammatory processes. Further studies on larger study populations are needed to clarify the underlying mechanisms. Funding: This presentation was supported by the Bridging Fund (Faculty of Medicine, University of Debrecen) and PD124126 project.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
atherosclerosis
familial hypercholesterolemia
progranulin
lipoprotein
inflammation
Megjelenés:Atherosclerosis. - 355 (2022), p. e248. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Juhász Lilla (1990-) (általános orvos) Szentpéteri Anita (1988-) (biológus) Sztanek Ferenc (1982-) (orvos) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM094676
Első szerző:Nádró Bíborka (általános orvos)
Cím:Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy / Bíborka Nádró, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, György Paragh, Péter Kempler, Mariann Harangi, Ferenc Sztanek
Dátum:2021
ISSN:0300-0605
Megjegyzések:Objectives: Progranulin (PGRN) is a secreted growth factor that helps to regulate neuronal survival by blocking tumor necrosis factor-alpha (TNFa) receptors. The antioxidant alpha-lipoic acid (ALA) is used in diabetic neuropathy to improve nerve conduction and relieve neuropathic pain, but its effects on PGRN levels have not yet been elucidated. Methods: In this prospective study, 54 patients with type 2 diabetes and peripheral neuropathy received 600 mg of ALA daily for 6 months. Twenty-four patients with diabetes without neuropathy were also included in the study. Serum PGRN and TNFa levels were determined using enzyme-linked immunosorbent assays. In addition, current perception threshold (CPT) testing was used to assess sensory neuropathy. Results: After ALA treatment, serum PGRN levels were significantly increased and CPT values were significantly improved. Furthermore, there were significant positive correlations among TNFa, ICAM-1, and PGRN levels both before and after ALA treatment. A significant negative correlation was observed between the improvements in CPT and the PGRN levels. Furthermore, ICAM-1 levels were an independent predictor of PGRN levels. Conclusions: Changes in serum PGRN levels indicate that ALA treatment may have beneficial effects on endothelial function and neuronal inflammation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic neuropathy
cardiac autonomic neuropathy
progranulin
intercellular adhesion molecule-1
alpha-lipoic acid
tumor necrosis factor-alpha
type 2 diabetes
Megjelenés:Journal of International Medical Research. - 49 : 5 (2021), p. 1-13. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes (1972-) (gyógytornász) Szentpéteri Anita (1988-) (biológus) Zöld Eszter (1988-) (szemész) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Kempler Péter (1954-) (belgyógyász, diabetológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Sztanek Ferenc (1982-) (orvos)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
OTKA-115723
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM017777
Első szerző:Seres Ildikó (biokémikus)
Cím:Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia / Seres I., Fóris G., Páll D., Kosztáczky B., Paragh Gy. Jr., Varga Zs., Paragh Gy.
Dátum:2005
ISSN:0026-0495
Megjegyzések:The aim of this study was to investigate the effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor fluvastatin (Flu) on angiotensin II (AII)-stimulated neutrophils of patients with hypercholesterolemia. Results suggest that a 6-week-long Flu administration completely counteracted the AII-induced increase in superoxide anion and leukotriene C4 production of the neutrophils of patients with hypercholesterolemia. However, the failure of signal processing through pertussis toxin-sensitive G protein, the increase in [Ca2+]i in membrane-bound protein kinase C activity, and the increase in neutrophil-bound cholesterol content were only partially restored by Flu. In addition, Flu had no effect on the increased membrane rigidity of the neutrophils of patients with hypercholesterolemia. To sum it up, Flu administration had a beneficial effect on AII-triggered reactive oxygen species generation; it resulted in partial restoration of signaling processes and of membrane composition, but membrane fluidity remained unchanged.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism - Clinical And Experimental. - 54 : 9 (2005), p. 1147-1154. -
További szerzők:Fóris Gabriella (1937-) (belgyógyász) Páll Dénes (1967-) (belgyógyász, kardiológus) Kosztáczky Béla (1967-) (orvos) Paragh György Jr. (1978-) (bőrgyógyász) Varga Zsuzsa (1951-) (biokémikus, nephrológus) Paragh György (1953-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM002312
Első szerző:Seres Ildikó (biokémikus)
Cím:Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL / Seres Ildikó, Fóris Gabriella, Kovács Éva, Páll Dénes, Varga Zsuzsa, Balogh Zoltán, Paragh György
Dátum:2007
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cell Biochemistry and Function. - 25 : 1 (2007), p. 55-62. -
További szerzők:Fóris Gabriella (1937-) (belgyógyász) Kovács Éva Páll Dénes (1967-) (belgyógyász, kardiológus) Varga Zsuzsa (1951-) (biokémikus, nephrológus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Paragh György (1953-) (belgyógyász)
Internet cím:elektronikus változat
DOI
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7.

001-es BibID:BIBFORM084638
Első szerző:Sztanek Ferenc (orvos)
Cím:Effect of alpha-lipoic acid treatment on plasma asymmetric dimethylarginine, a biomarker of endothelial dysfunction in diabetic neuropathy / Ferenc Sztanek, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, Mariann Harangi, Péter Kempler, György Paragh
Dátum:2020
ISSN:1734-1922
Megjegyzések:Introduction: Diabetic neuropathy may develop on a background of hyperglycemia and is associated with increased oxidative stress. Elevated asymmetric dimethylarginine (ADMA) levels are linked to oxidative stress reducing the synthesis of nitric oxide (NO) by uncoupling NO synthase. Oxidative stress induces considerable changes in nerve conduction velocity in diabetic patients. There is strong evidence that alpha-lipoic acid (ALA) as an antioxidant may improve nerve conduction and relieve neuropathic symptoms. We aimed to investigate the relationship between endothelial dysfunction and NO synthesis in type 2 diabetic patients with peripheral neuropathy after ALA treatment. Materials and Methods: Fifty-four type 2 diabetic patients with neuropathy were included in the study. Serum ADMA concentration, ICAM-1, VCAM-1, oxLDL and TNF-alpha levels were determined with ELISA. NO concentration was measured by Griess reaction. Peripheral sensory nerve function was assessed by current perception threshold (CPT) testing. Autonomic function was assessed by Ewing's five standard cardiovascular reflex tests (CAS). Results: ADMA levels were significantly decreased (0.62?0.11 vs. 0.53?0.11 ?mol/l, p<0.001), as well as TNF-alpha concentrations (1.21?0.42 pg/ml vs. 1.05?0.5 pg/ml, p<0.05); while NO levels were significantly increased (16.78?11.1 vs. 21.58?8.84 ?mol/l, p<0.05) after six month of 600 mg/day ALA treatment. VCAM-1, ICAM-1 and oxLDL levels did not change significantly. The CPT and CAS significantly improved after ALA treatment. The improvement of current perception threshold values was correlated positively with the change of ADMA levels (r=0.58, p<0.001). Change in ADMA level was more pronounced in responder patients based on both CPT and CAS. Conclusions: Our results suggest that ALA supplementation improves endothelial function characterized by serum levels of ADMA and TNF-alpha in patients with diabetic neuropathy. Changes in serum ADMA levels may predict the clinical response to ALA treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic neuropathy
cardiac autonomic neuropathy
nitric oxide
asymmetric dimethylarginine
alpha-lipoic acid
Megjelenés:Archives of Medical Science. - 2020 (2020), p. 1-9. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes (1972-) (gyógytornász) Szentpéteri Anita (1988-) (biológus) Zöld Eszter (1988-) (szemész) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:OTKA-115723
OTKA
EFOP-3.6.2-16-2017-00009
EFOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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