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001-es BibID:BIBFORM029870
035-os BibID:PMID:22017293
Első szerző:Auriel, Eitan
Cím:Leukoaraiosis is associated with arterial wall thickness : a quantitative analysis / Auriel Eitan, Csiba Laszlo, Berenyi Ervin, Varkonyi Ildiko, Mehes Gabor, Kardos Laszlo, Karni Arnon, Bornstein Natan M.
Dátum:2012
ISSN:0919-6544
Megjegyzések:Leukoaraiosis refers to an age-related, abnormal appearance of the brain white matter on neuroimaging. The association between leukoaraiosis and cerebrovascular disease suggests that ischemia may be an important contributing factor; however, the pathogenesis of the condition remains controversial. We hypothesized that physical abnormalities of blood vessels might be culpable and compared the external and internal measurements of blood vessel walls between brains that demonstrated leukoaraiosis on imaging and normal control brains. Fourteen brains of individuals who had been diagnosed as having severe leukoaraiosis and five non-leukoaraiosis control brains were studied. Arterial cross-sections were evaluated by length measurements with an image analysis device. Arterial wall thickness and the ratio of the outer and inner diameters of the vessel were measured. We measured a total of 108 vessels in the leukoaraiosis group and 95 vessels in the control group. The vessel walls of the leukoaraiosis patients were an average of 5.5 mikrom thicker than the walls of control vessels of the same inside diameter (P = 0.0000, 95% CI 3.01-8.08) and an average of 2.3 mikrom thicker than walls of control vessels of the same outside diameter (P = 0.016, 95% CI 0.48-4.17). Our data provide evidence that leukoaraiosis is associated with vessel wall thickening in an additive fashion and indicate that structural vascular abnormalities are associated with leukoaraiosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuropathology. - 32 : 3 (2012), p. 227-233. -
További szerzők:Csiba László (1952-) (neurológus, pszichiáter) Berényi Ervin (1964-) (radiológus) Várkonyi Ildikó (szakorvos jelölt) Méhes Gábor (1966-) (patológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Karni, Arnon Bornstein, Natan M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM016921
035-os BibID:(WoS)000284961100007 (Scopus)78650048739
Első szerző:Auriel, Eitan
Cím:Clinical, radiological and pathological correlates of leukoaraiosis / Auriel, E., Bornstein, N. M., Berenyi, E., Varkonyi, I., Mehes, G., Majtenyi, K., Szepesi, R., Goldberg, I., Lampe, R., Csiba, L.
Dátum:2011
ISSN:0001-6314
Megjegyzések:Introduction - Leukoaraiosis is characterized by an abnormal appearanceof the brain white matter on imaging. Its pathogenesis is still amatter of investigation. The purpose of this study was to investigatethe radiological, clinical and pathological correlates ofleukoaraiosis. Methods - The study population consisted of 93 deceasedpatients. The pre-mortem T2W magnetic resonance images were evaluatedfor the presence and grading of leukoaraiosis. The clinical andpathological characteristics based on the clinical charts and autopsyreports were evaluated. Tissue specimens of the blocks of 19 brainsthat demonstrated severe leukoaraiosis and those of five control brainswere excised and stained. Results - The variables found to besignificantly associated with leukoaraiosis were age and a clinicalhistory of Parkinson's disease. Other risk factors and pathologicalmarkers of atherosclerosis were not significantly correlated withleukoaraiosis. No significant difference was found between the scoringof the myelin integrity, glial fibrillary acidic protein, cluster ofdifferentiation 68 and smooth muscle actin. There was a significantdifference with respect to thickening of vessels walls. Conclusions - Our pathological results indicate that structural vascularabnormalities characterized by vessel wall thickening are associatedwith leukoaraiosis, supporting the assertion that vascular changes andischemia generate leukoaraiosis. The relations between parkinsonism andleukoaraiosis may be explicable through vascular effects on thecircuitry of the basal ganglia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Acta Neurologica Scandinavica. - 123 : 1 (2011), p. 41-47. -
További szerzők:Bornstein, Natan M. Berényi Ervin (1964-) (radiológus) Várkonyi Ildikó (szakorvos jelölt) Méhes Gábor (1966-) (patológus) Majtényi K. Szepesi Rita (1975-) (neurológus) Goldberg, Isaac Lampé Rudolf (1983-) (szülész-nőgyógyász) Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:DOI
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