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001-es BibID:	BIBFORM016927
035-os BibID:	(WoS)000089532600022 (Scopus)0033799578
Első szerző:	Sedin, Gunna
Cím:	Lung water and proton magnetic resonance relaxation in preterm and termrabbit pups : their relation to tissue hyaluronan / Sedin G., Bogner P., Berényi E., Repa I., Nyúl Z., Sulyok E.
Dátum:	2000
ISSN:	0031-3998
Megjegyzések:	The present study was performed to investigate simultaneously totallung water, T-1 and T-2 relaxation times, and hyaluronan (HA) inpreterm and term rabbits. Attempts were also made to establish therelationship of HA to total lung water and to T-2-derived motionallydistinct water fractions. Experiments were performed in fetal Pannonwhite rabbit pups at gestational ages of 25, 27, 29, and 31 d and at apostnatal age of 4 d. Lung tissue water content (desiccation method),T-1 and T-2 relaxation times (H-1-NMR method), and HA concentration(radioassay) were measured, and free and bound water fractions werecalculated by using multicomponent fits of the T-2 relaxation curves.Lung water content and T-1 and T-2 relaxation times were highest at agestational age of 27 d and then declined steadily during the wholestudy period. Similar trends and time courses were seen for the fastand slow components of the T-2 relaxation curve. The T-2-derived freewater fraction remained unchanged at a gestational age of 25-29 d(similar to 67%), but increased progressively to a value of 78.5 +/-7.9% at 31 d (p < 0.001) and to 83.4 +/- 9.4% at the postnatal age of 4d (p < 0.01), Opposite changes occurred in the bound water fraction.Lung HA concentration decreased with advancing gestation from 870.8 +/-205.2 mu g/g dry weight at 25 d to 162.6 +/- 32.4 mu g/g dry weight at31 d (p < 0.001), but it was increased 2-fold postnatally, EIAcorrelated positively with total lung water (r = 0.39; p < 0.001) butnot with the bound water fraction. It is suggested that the physiologiclung dehydration is associated with macromolecule-relatedreorganization of lung water and that the role of IIA in this processneeds to be further investigated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pediatric Research. - 48 : 4 (2000), p. 554-559. -
További szerzők:	Bogner Péter (1963-) (radiológus) Berényi Ervin (1964-) (radiológus) Repa Imre (1950-) (radiológus) Nyúl Zoltán Sulyok Endre
Internet cím:	DOI
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001-es BibID:	BIBFORM016926
035-os BibID:	(WoS)000166385500013 (Scopus)0035165276
Első szerző:	Sulyok Endre
Cím:	Brain water and proton magnetic resonance relaxation in preterm and term rabbit pups : their relation to tissue hyaluronan / Sulyok E., Nyúl Z., Bogner P., Berényi E., Repa I., Vajda Z., Dóczi T., Sedin G.
Dátum:	2001
ISSN:	0006-3126
Megjegyzések:	The present study was performed to investigate simultaneously totalbrain water, T1 and T2 relaxation times, and hyaluronan (HA) in fetaland neonatal rabbits. Attempts were also made to establish therelationship of HA to total brain water and to T2-derived motionallydistinct water fractions, since HA is known to bind water and to limittissue water mobility. Experiments were carried out in fetal Pannonwhite rabbit pups at gestational ages of 25, 27, 29, and 31 days and ata postnatal age of 4 days. The brain tissue water content (desiccationmethod), T1 and T2 relaxation times (H-1-NMR method), and HAconcentration (radioassay HA 50) were measured, and free and boundwater fractions were calculated by using multicomponent fits of the T2relaxation curves. Compared with values in newborn pups, water and HAcontents were found to be highly elevated in the preterm brain anddecreased markedly during early postnatal life. The trends and timecourses of T1 and T2 relaxation times proved to be similar, but thepostnatal decrease in T2 was preceded by a significant decline in lategestation. Maturity-related changes occurred in the T2 relaxationderived bound water fraction which amounted to 4-19% of brain water.The bound water fraction appeared to be independent of total brainwater and HA concentration, and HA is, therefore, unlikely to be theonly factor controlling brain water mobility. The clear dissociation ofbound water fraction from total water suggests restructuring of brainwater during the perinatal period.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biology of the Neonate. - 79 : 1 (2001), p. 67-72. -
További szerzők:	Nyúl Zoltán Bogner Péter (1963-) (radiológus) Berényi Ervin (1964-) (radiológus) Repa Imre (1950-) (radiológus) Vajda Zsolt Dóczi Tamás Sedin, Gunna
Internet cím:	DOI elektronikus változat
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