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001-es BibID:	BIBFORM035696
Első szerző:	Jakab András
Cím:	Generation of Individualized Thalamus Target Maps by Using Statistical Shape Models and Thalamocortical Tractography / Jakab, A., Blanc, R., Berenyi, E. L., Szekely, G.
Dátum:	2012
ISSN:	0195-6108
Megjegyzések:	Neurosurgical interventions of the thalamus rely on transferring stereotactic coordinates from an atlas onto the patient's MR brain images. We propose a prototype application for performing thalamus target map individualization by fusing patient-specific thalamus geometric information and diffusion tensor tractography. MATERIALS AND METHODS: Previously, our workgroup developed a thalamus atlas by fusing anatomic information from 7 histologically processed thalami. Thalamocortical connectivity maps were generated from DTI scans of 40 subjects by using a previously described procedure and were mapped to a standard neuroimaging space. These data were merged into a statistical shape model describing the morphologic variability of the thalamic outline, nuclei, and connectivity landmarks. This model was used to deform the atlas to individual images. Postmortem MR imaging scans were used to quantify the accuracy of nuclei predictions. RESULTS: Reliable tractography-based markers were located in the ventral lateral thalamus, with the somatosensory connections coinciding with the VPLa and VPLp nuclei; and motor/premotor connections, with the VLpv and VLa nuclei. Prediction accuracy of thalamus outlines was higher with the SSM approach than the ACPC alignment of data (0.56 mm versus 1.24; Dice overlap: 0.87 versus 0.7); for individual nuclei: 0.65 mm, Dice: 0.63 (SSM); 1.24 mm, Dice: 0.4 (ACPC). CONCLUSIONS: Previous studies have already applied DTI to the thalamus. As a further step in this direction, we demonstrate a hybrid approach by using statistical shape models, which have the potential to cope with intersubject variations in individual thalamus geometry.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	American Journal Of Neuroradiology. - 33 : 11 (2012), p. 2110-2116. -
További szerzők:	Blanc, Remi Berényi Ervin (1964-) (radiológus) Székely György (1926-2017) (neurobiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM034326
Első szerző:	Jakab András
Cím:	Mapping changes of in vivo connectivity patterns in the human mediodorsal thalamus : correlations with higher cognitive and executive functions / Jakab András, Blanc Remi, Berényi Ervin L.
Dátum:	2012
ISSN:	1931-7557
Megjegyzések:	The mediodorsal thalamic nucleus is recognized as an association hub mediating interconnections with mainly the prefrontal cortex. Tracer studies in primates and in vivo diffusion tensor tractography findings in both humans and monkeys confirm its role in relaying networks that connect to the dorsolateral prefrontal, orbitofrontal, frontal medial and cingulate cortex. Our study was designed to use in vivo probabilistic tractography to describe the pathways emerging from or projecting to the mediodorsal nucleus; moreover, to use such information to automatically define subdivisions based on the divergence of remote structural connections. Diffusion tensor MR imaging data of 156 subjects were utilized to perform connectivity-based segmentation of the mediodorsal nucleus by employing a k-means clustering algorithm. Two domains were revealed (medial and lateral) that are separated from each other by a sagittally oriented plane. For each subject, general assessment of cognitive performance by means of the Wechsler Abbreviated Scale of Intelligence and measures of Delis-Kaplan Executive Function System (D-KEFS) test was utilized. Inter-subject variability in terms of connectivity-based cluster sizes was discovered and the relative sizes of the lateral mediodorsal domain correlated with the individuals' performance in the D-KEFS Sorting test (r = 0.232, p = 0.004). Our results show that the connectivity-based parcellation technique applied to the mediodorsal thalamic nucleus delivers a single subject level descriptor of connectional topography; furthermore, we revealed a possible weak interaction between executive performance and the size of the thalamic area from which pathways converge to the lateral prefrontal cortex.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Brain Imaging and Behavior. - 6 : 3 (2012), p. 472-483. -
További szerzők:	Blanc, Remi Berényi Ervin (1964-) (radiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030800
Első szerző:	Jakab András
Cím:	Connectivity-augmented surgical targeting : individualization of a mean three-dimensional atlas of the human thalamus / A. Jakab, R. Blanc, A. Morel, E. Berenyi, G. Szekely
Dátum:	2011
ISSN:	0028-3940
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt diffusion tensor imaging neurosurgery egyetemen (Magyarországon) készült közlemény
Megjelenés:	Neuroradiology 53 : S1 (2011), p. S24. -
További szerzők:	Blanc, Remi Morel, Anne Berényi Ervin (1964-) (radiológus) Székely Gábor
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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