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001-es BibID:	BIBFORM052715
Első szerző:	Shih, David J. H.
Cím:	Cytogenetic prognostication within medulloblastoma subgroups / David J. H. Shih, Paul A. Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M. G. Cavalli, David T. W. Jones, Karel Zitterbart, Claudia C. Faria, Ulrich Schüller, Leos Kren, Toshihiro Kumabe, Teiji Tominaga, Young Shin Ra, Miklós Garami, Peter Hauser, Jennifer A. Chan, Shenandoah Robinson, László Bognár, Almos Klekner, Ali G. Saad, Linda M. Liau, Steffen Albrecht, Adam Fontebasso, Giuseppe Cinalli, Pasqualino De Antonellis, Massimo Zollo, Michael K. Cooper, Reid C. Thompson, Simon Bailey, Janet C. Lindsey, Concezio Di Rocco, Luca Massimi, Erna M. C. Michiels, Stephen W. Scherer, Joanna J. Phillips, Nalin Gupta, Xing Fan, Karin M. Muraszko, Rajeev Vibhakar, Charles G. Eberhart, Maryam Fouladi, Boleslaw Lach, Shin Jung, Robert J. Wechsler-Reya, Michelle Fèvre-Montange, Anne Jouvet, Nada Jabado, Ian F. Pollack, William A. Weiss, Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Jeffrey R. Leonard, Joshua B. Rubin, Carmen de Torres, Cinzia Lavarino, Jaume Mora, Yoon-Jae Cho, Uri Tabori, James M. Olson, Amar Gajjar, Roger J. Packer, Stefan Rutkowski, Scott L. Pomeroy, Pim J. French, Nanne K. Kloosterhof, Johan M. Kros, Erwin G. Van Meir, Steven C. Clifford, Franck Bourdeaut, Olivier Delattre, François F. Doz, Cynthia E. Hawkins, David Malkin, Wieslawa A. Grajkowska, Marta Perek-Polnik, Eric Bouffet, James T. Rutka, Stefan M. Pfister, Michael D. Taylor
Dátum:	2014
ISSN:	0732-183X 1527-7755
Megjegyzések:	Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication.Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models.Results Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas.Conclusion Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Clinical Oncology. - 32 : 9 (2014), p. 886-896. -
További szerzők:	Northcott, Paul A. Remke, Marc Korshunov, Andrey Ramaswamy, Vijay Kool, Marcel Luu, Betty Yao, Yuan Wang, Xin Dubuc, Adrian Garzia, Livia Peacock, John Mack, Stephen Wu, Xiaochong Rolider, Adi Morrissy, Sorana Cavalli, Florence M. G. Jones, David T. W. Zitterbart, Karel Faria, Claudia C. Schüller, Ulrich Kren, Leos Kumabe, Toshihiro Tominaga, Teiji Shin Ra, Young Garami Miklós Hauser, Peter Chan, Jennifer A. Robinson, Shenandoah Bognár László (1958-) (idegsebész, gyermekidegsebész) Klekner Álmos (1970-) (idegsebész) Saad, Ali G. Liau, Linda M. Albrecht, Stephen Fontebasso, Adam M. Cinalli, Giuseppe De Antonellis, Pasqualino Zollo, Massimo Cooper, Michael K. Thompson, Reid C. Bailey, Simon Lindsey, Janet C. Di Rocco, Concezio Massimi, Luca Michiels, Erna M. C. Scherer, Stephen W. Phillips, Joanna J. Gupta, Nalin Fan, Xing Muraszko, Karin M. Vibhakar, Rajeev Eberhart, Charles G. Fouladi, Maryam Lach, Boleslaw Jung, Shin Wechsler-Reya, Robert J. Fèvre-Montange, Michelle Jouvet, Anne Jabado, Nada Pollack, Ian F. Weiss, William A. Lee, Ji-Yeoun Cho, Byung-Kyu Kim, Seung-Ki Wang, Kyu-Chang Leonard, Jeffrey R. Rubin, Joshua B. Torres, Carmen, de Lavarino, Cinzia Mora, Jaume Cho, Yoon-Jae Tabori, Uri Olson, James M. Gajjar, Amar Packer, Roger J. Rutkowski, Stefan Pomeroy, Scott L. French, Pim J. Kloosterhof, Nanne K. Kros, Johan M. van Meir, Erwin G. Clifford, Steven C. Bourdeaut, Franck Delattre, Olivier Doz, François F. Hawkins, Cynthia E. Malkin, David Grajkowska, Wieslawa A. Perek-Polnik, Marta Bouffet, Eric Rutka, James T. Pfister, Stefan M. Taylor, Michael D.
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001-es BibID:	BIBFORM082160
035-os BibID:	(WoS)000493807800049 (Scopus)85074231650 (PMID)31664194
Első szerző:	Suzuki, Hiromichi
Cím:	Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma / Suzuki, Hiromichi; Kumar, Sachin A.; Shuai, Shimin; Diaz-Navarro, Ander; Gutierrez-Fernandez, Ana; De Antonellis, Pasqualino; Cavalli, Florence M. G.; Juraschka, Kyle; Farooq, Hamza; Shibahara, Ichiyo; Vladoiu, Maria C.; Zhang, Jiao; Abeysundara, Namal; Przelicki, David; Skowron, Patryk; Gauer, Nicole; Luu, Betty; Daniels, Craig; Wu, Xiaochong; Forget, Antoine; Momin, Ali; Wang, Jun; Dong, Weifan; Kim, Seung-Ki; Grajkowska, Wieslawa A.; Jouvet, Anne; Fèvre-Montange, Michelle; Garre, Maria Luisa; Nageswara Rao, Amulya A.; Giannini, Caterina; Kros, Johan M.; French, Pim J.; Jabado, Nada; Ng, Ho-Keung; Poon, Wai Sang; Eberhart, Charles G.; Pollack, Ian F.; Olson, James M.; Weiss, William A.; Kumabe, Toshihiro; López-Aguilar, Enrique; Lach, Boleslaw; Massimino, Maura; Van Meir, Erwin G.; Rubin, Joshua B.; Vibhakar, Rajeev; Chambless, Lola B.; Kijima, Noriyuki; Klekner, Almos; Bognár, László; Chan, Jennifer A.; Faria, Claudia C.; Ragoussis, Jiannis; Pfister, Stefan M.; Goldenberg, Anna; Wechsler-Reya, Robert J.; Bailey, Swneke D.; Garzia, Livia; Morrissy, A. Sorana; Marra, Marco A.; Huang, Xi; Malkin, David; Ayrault, Olivier; Ramaswamy, Vijay; Puente, Xose S.; Calarco, John A.; Stein, Lincoln; Taylor, Michael D.
Dátum:	2019
ISSN:	0028-0836
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nature. - 574 : 7780 (2019), p. 707-711. -
További szerzők:	Kumar, Sachin A. Shuai, Shimin Diaz-Navarro, Ander Gutierrez-Fernandez, Ana De Antonellis, Pasqualino Cavalli, Florence M. G. Juraschka, Kyle Farooq, Hamza Shibahara, Ichiyo Vladoiu, Maria C. Zhang, Jiao Abeysundara, Namal Przelicki, David Skowron, Patryk Gauer, Nicole Luu, Betty Daniels, Craig Wu, Xiaochong Forget, Antoine Momin, Ali Wang, Jun Dong, Weifan Kim, Seung-Ki Grajkowska, Wieslawa A. Jouvet, Anne Fèvre-Montange, Michelle Garre, Maria Luisa Nageswara Rao, Amulya A. Giannini, Caterina Kros, Johan M. French, Pim J. Jabado, Nada Ng, Ho-Keung Poon, Wai Sang Eberhart, Charles G. Pollack, Ian F. Olson, James M. Weiss, William A. Kumabe, Toshihiro Lopez-Aguilar, Enrique Lach, Boleslaw Massimino, Maura van Meir, Erwin G. Rubin, Joshua B. Vibhakar, Rajeev Chambless, Lola B. Kijima, Noriyuki Klekner Álmos (1970-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Chan, Jennifer A. Faria, Claudia C. Ragoussis, Jiannis Pfister, Stefan M. Goldenberg, Anna Wechsler-Reya, Robert J. Bailey, Swneke D. Garzia, Livia Morrissy, Sorana Marra, Marco A. Huang, Xi Malkin, David Ayrault, Olivier Ramaswamy, Vijay Puente, Xose S. Calarco, John A. Stein, Lincoln Taylor, Michael D.
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001-es BibID:	BIBFORM066682
Első szerző:	Torchia, Jonathon
Cím:	Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors / Torchia Jonathon, Golbourn Brian, Feng Shengrui, Ho King Ching, Sin-Chan Patrick, Vasiljevic Alexandre, Norman Joseph D., Guilhamon Paul, Garzia Livia, Agamez Natalia R., Lu Mei, Chan Tiffany S. Y., Picard Daniel, de Antonellis Pasqualino, Khuong-Quang Dong-Anh, Planello Aline C., Zeller Constanze, Barsyte-Lovejoy Dalia, Lafay-Cousin Lucie, Letourneau Louis, Bourgey Mathieu, Yu Man, Gendoo Deena M. A., Dzamba Misko, Barszczyk Mark, Medina Tiago, Riemenschneider Alexandra N., Morrissy A. Sorana, Ra Young-Shin, Ramaswamy Vijay, Remke Marc, Dunham Christopher P., Yip Stephen, Ng Ho-keung, Lu Jian-Qiang, Mehta Vivek, Albrecht Steffen, Pimentel Jose, Chan Jennifer A., Somers Gino R., Faria Claudia C., Roque Lucia, Fouladi Maryam, Hoffman Lindsey M., Moore Andrew S., Wang Yin, Choi Seung Ah, Hansford Jordan R., Catchpoole Daniel, Birks Diane K., Foreman Nicholas K., Strother Doug, Klekner Almos, Bognár Laszló, Garami Miklós, Hauser Péter, Hortobágyi Tibor, Wilson Beverly, Hukin Juliette, Carret Anne-Sophie, Van Meter Timothy E., Hwang Eugene I., Gajjar Amar, Chiou Shih-Hwa, Nakamura Hideo, Toledano Helen, Fried Iris, Fults Daniel, Wataya Takafumi, Fryer Chris, Eisenstat David D., Scheineman Katrin, Fleming Adam J., Johnston Donna L., Michaud Jean, Zelcer Shayna, Hammond Robert, Afzal Samina, Ramsay David A., Sirachainan Nongnuch, Hongeng Suradej, Larbcharoensub Noppadol, Grundy Richard G., Lulla Rishi R., Fangusaro Jason R., Druker Harriet, Bartels Ute, Grant Ronald, Malkin David, McGlade C. Jane, Nicolaides Theodore, Tihan Tarik, Phillips Joanna, Majewski Jacek, Montpetit Alexandre, Bourque Guillaume, Bader Gary D., Reddy Alyssa T., Gillespie G. Yancey, Warmuth-Metz Monika, Rutkowski Stefan, Tabori Uri, Lupien Mathieu, Brudno Michael, Schüller Ulrich, Pietsch Torsten, Judkins Alexander R., Hawkins Cynthia E., Bouffet Eric, Kim Seung-Ki, Dirks Peter B., Taylor Michael D., Erdreich-Epstein Anat, Arrowsmith Cheryl H., De Carvalho Daniel D., Rutka James T., Jabado Nada, Huang Annie
Dátum:	2016
ISSN:	1535-6108
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Cancer Cell 30 : 6 (2016), p. 891-908. -
További szerzők:	Golbourn, Brian Feng, Shengrui Ho, King Ching Sin-Chan, Patrick Vasiljevic, Alexandre Norman, Joseph D. Guilhamon, Paul Garzia, Livia Agamez, Natalia R. Lu, Mei Chan, Tiffany Sin Yu Picard, Daniel De Antonellis, Pasqualino Khuong-Quang, Dong-Anh Planello, Aline C. Zeller, Constanze Barsyte-Lovejoy, Dalia Lafay-Cousin, Lucie Letourneau, Louis Bourgey, Mathieu Yu, Man Gendoo, Deena M. A. Dzamba, Misko Barszczyk, Mark Medina, Tiago Riemenschneider, Alexandra N. Morrissy, Sorana Ra, Young-Shin Ramaswamy, Vijay Remke, Marc Dunham, Christopher P. Yip, Stephen Ng, Ho-Keung Lu, Jian-Qiang Mehta, Vivek Albrecht, Stephen Pimentel, José Chan, Jennifer A. Somers, Gino R. Faria, Claudia C. Roque, Lucia Fouladi, Maryam Hoffman, Lindsey M. Moore, Andrew S. Wang, Yin Choi, Seung Ah Hansford, Jordan R. Catchpoole, Daniel Birks, Diane Foreman, Nicholas K. Strother, Douglas Klekner Álmos (1970-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Garami Miklós Hauser Péter Hortobágyi Tibor (1965-) (patológus) Wilson, Beverly Hukin, Juliette Carret, Anne-Sophie van Meter, Timothy E. Hwang, Eugene Gajjar, Amar Chiou, Shih-Hwa Nakamura, Hideo Toledano, Helen Fried, Iris Fults, Daniel Wataya, Takafumi Fryer, Chris Eisenstat, David D. Scheineman, Katrin Fleming, Adam Johnston, Donna Michaud, Jean Zelcer, Shayna Hammond, Robert Afzal, Samina Ramsay, David A. Sirachainan, Nongnuch Hongeng, Suradej Larbcharoensub, Noppadol Grundy, Richard G. Lulla, Rishi R. Fangusaro, Jason R. Druker, Harriet Bartels, Ute Grant, Ronald Malkin, David McGlade, C. Jane Nicolaides, Theodore Tihan, Tarik Phillips, Joanna J. Majewski, Jacek Montpetit, Alexandre Bourque, Guillaume Bader, Gary D. Reddy, Alyssa T. Gillespie, G. Yancey Warmuth-Metz, Monika Rutkowski, Stefan Tabori, Uri Lupien, Mathieu Brudno, Michael Schüller, Ulrich Pietsch, Torsten Judkins, Alexander R. Hawkins, Cynthia E. Bouffet, Eric Kim, Seung-Ki Dirks, Peter Taylor, Michael D. Erdreich-Epstein, Anat Arrowsmith, Cheryl H. De Carvalho, Daniel D. Rutka, James T. Jabado, Nada Huang, Annie
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