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001-es BibID:	BIBFORM069060
Első szerző:	Hortobágyi Tibor (patológus)
Cím:	Pathophysiology of meningioma growth in pregnancy / Hortobágyi Tibor, Bencze János, Murnyák Balázs, Kouhsari Mahan C., Bognár László, Marko-Varga György
Dátum:	2017
ISSN:	2391-5463
Megjegyzések:	Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The increased meningioma growth observed in pregnancy is presumably the result of endocrine mechanisms. These include increase in progesterone, human placental lactogen (hPL) and prolactin (PRL) serum levels. In contrast, levels of pituitary hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic gonadotropin (hCG) produced by the placenta are decreasing in the mother prior to childbirth. Besides, vascular factors also play a crucial role. Peritumoral brain edema (PTBE), with well-known causative association with vascular endothelial growth factor (VEGF), can often be seen both with imaging and in the surgical specimens. Our aim is to assess published research on this topic including diagnostic and therapeutic guidelines, and to provide a clinically useful overview on the pathophysiology and biological behaviour of this rare complication of pregnancy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban meningioma pregnancy pathophysiology endocrinology hemodynamics
Megjelenés:	Open Medicine 12 (2017), p. 195-200. -
További szerzők:	Bencze János (1991-) (orvos) Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Kouhsari, Mahan C. Bognár László (1958-) (idegsebész, gyermekidegsebész) Marko-Varga György
Pályázati támogatás:	KTIA 13 NAP-A-II/7 MTA GINOP-2.3.2-15-2016-00043 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM077127
Első szerző:	Virga József
Cím:	Extracellular matrix differences in glioblastoma patients with different prognoses / Virga J., Szivos L., Hortobágyi T., Kouhsari M. C., Zahuczky G., Steiner L., Tóth J., Reményi-Puskár J., Bognár L., Klekner Á.
Dátum:	2019
Megjegyzések:	Glioblastoma is the most common malignant central nervous system tumor. Patient outcome remains poor despite the development of therapy and increased understanding of the disease in the past decades. Glioma cells invade the peritumoral brain, which results in inevitable tumor recurrence. Previous studies have demonstrated that the extracellular matrix (ECM) is altered in gliomas and serves a major role in glioma invasion. The present study focuses on differences in the ECM composition of tumors in patients with poor and improved prognosis. The mRNA and protein expression of 16 invasion?associated ECM molecules was determined using reverse trascription?quantitiative polymerase chain reaction and immunohistochemistry, respectively. Clinical factors of patients with different prognoses was also analyzed. It was determined that age and postoperative Karnofsky performance score were associated with patient survival. Furthermore, Fms?related tyrosine kinase 4/vascular endothelial growth factor receptor 3 (FLT4/VEGFR3), murine double minute 2 (MDM2) and matrix metallopeptidase 2 (MMP2) mRNA levels were significantly different between the two prognostic groups. Additionally, brevican, cluster of differentiation 44, hyaluronan mediated motility receptor, integrin??V and ??1, and MDM2 protein expression were indicated to be significantly different in immunohistochemistry slides. Using the expression profile, including the invasion spectrum of the samples, it was possible to identify the prognostic group of the sample with high efficacy, particularly in cases with poor prognosis. In conclusion, it was determined that ECM components exhibit different expression levels in tumors with different prognoses and thus the invasion spectrum can be used as a prognostic factor in glioblastoma.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Oncology letters. - 17 : 1 (2019), p. 797-806. -
További szerzők:	Szivos László (1993-) (idegsebész) Hortobágyi Tibor (1965-) (patológus) Kouhsari, Mahan C. Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Steiner László Tóth Judit (1958-) (onkológus szakorvos) Reményi-Puskár Judit Bognár László (1958-) (idegsebész, gyermekidegsebész) Klekner Álmos (1970-) (idegsebész)
Pályázati támogatás:	2017-1.2.1-NKP-2017-00002 Egyéb ÚNKP-17-3-I and ÚNKP-17-2-I ÚNKP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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