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001-es BibID:BIBFORM069451
035-os BibID:(WOS)000427432400020 (Scopus)85019612221
Első szerző:Kárai Bettina (orvos)
Cím:Expression of Coagulation Factor XIII Subunit A Correlates with Outcome in Childhood Acute Lymphoblastic Leukemia / Bettina Kárai, Zsuzsanna Hevessy, Eszter Szánthó, László Csáthy, Anikó Ujfalusi, Katalin Gyurina, István Szegedi, János Kappelmayer, Csongor Kiss
Dátum:2018
ISSN:1219-4956 1532-2807
Megjegyzések:Abstract Previously we identified B-cell lineage leukemic lymphoblasts as a new expression site for subunit A of blood coagulation factor XIII (FXIII-A). On the basis of FXIII-A expression, various subgroups of B-cell precursor acute lymphoblasticleukemia (BCP-ALL) can be identified. Fifty-five children with BCP-ALL were included in the study. Bone marrow samples were obtained by aspiration and the presenceof FXIII-A was detected by flow cytometry. G-banding and fluorescent in situ hybridization was performed according to standard procedures. The 10-year event-free survival (EFS)and overall survival (OS) rate of FXIII-A-positive and FXIII-A-negative patients showed significant differences (EFS: 84% vs. 61%, respectively; p = 0.031; OS: 89% vs.61%; p = 0.008). Of all the parameters examined, there was correlation only between FXIII-A expression and ♭B-other' genetic subgroup. Further multivariate Cox regression analysis of FXIII-subtype and genetic group or ♭B-other' subgroup identified the FXIII-A negative characteristic as an independent factor associated with poor outcome in BCP-ALL. We found an excellent correlation between long-term survival and the FXIII-A-positive phenotype of BCP lymphoblasts at presentation. The results presented seem to be convincing enough to suggest a possible role for FXIII-A expression in the prognostic grouping of childhood BCP-ALL patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Precursor B-cell acute lymphoblastic leukemia
Immunophenotype
Factor XIII-A
B-other' ALL
Megjelenés:Pathology and Oncology Research. - 24 : 2 (2018), p. 345-352. -
További szerzők:Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos) Szánthó Eszter (laboratóriumi szakorvos jelölt) Csáthy László (1979-) (laboratóriumi szakorvos) Ujfalusi Anikó (1968-) (gyermekorvos, laboratóriumi szakorvos) Gyurina Katalin (1986-) (tudományos segédmunkatárs) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:DOI
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2.

001-es BibID:BIBFORM034576
Első szerző:Simon Ágnes (laboratóriumi szakorvos)
Cím:Expression of coagulation factor XIII subunit A in acute promyelocytic leukemia / Ágnes Simon, Zsuzsa Bagoly, Zsuzsanna Hevessy, László Csáthy, Éva Katona, György Vereb, Anikó Ujfalusi, László Szerafin, László Muszbek, János Kappelmayer
Dátum:2012
ISSN:1552-4949
Megjegyzések:Leukemic cells often express markers which are not characteristic of their particular cell lineage. In this study we identified the "A" subunit of coagulation factor XIII (FXIII-A) in leukemic promyelocytes in de novo AML M3 cases. The cytoplasmic presence of factor XIII-A has previously been shown only in platelets/megakaryocytes and monocytes/macrophages. Furthermore, more recently we described the presence of FXIII-A in leukemic lymphoblasts. We studied 14 patients with this rare type of acute leukemia in a period of 4 years and investigated their bone marrow samples by 3-color flow cytometry upon diagnosis, mainly focusing on FXIII-A expression of leukemic cells. We detected FXIII-A also by ELISA, Western-blot and confocal laser scanning microscopy. This was a homogenous group of AML M3 patients with translocation t(15;17)(q22;q21) detected by fluorescence in situ hybridization (FISH). In 10 out of 14 samples, FXIII-A was detectable by flow cytometry and was coexpressed with markers characteristic for leukemic promyleocytes (CD45dim/CD13+/CD33+/CD117+/cyMPO+ and HLA-DR-/CD34-/CD14-/CD15-). Staining for the markers GPIIb and GPIX were negative, and FXIII-A was identified in the cytoplasm of the cells by confocal microscopy in a relatively high quantity, as measured by ELISA. By Western blot analysis we could identify FXIII-A in the native 82 kD form and in cleaved forms corresponding to cleavage products observed when purified FXIII-A was treated by human neutrophil elastase. Since normal promyelocytes were FXIII-A negative, this novel expression site of FXIII-A in AML M3 can be considered as a leukemia associated immunophenotype and may have pathophysiological significance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Molekuláris Medicina
Megjelenés:Cytometry. Part B. Clinical Cytometry. - 82B : 4 (2012), p. 209-216. -
További szerzők:Bagoly Zsuzsa (1978-) (orvos) Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos) Csáthy László (1979-) (laboratóriumi szakorvos) Katona Éva (1961-) (klinikai biokémikus) Vereb György (1965-) (biofizikus, orvos) Ujfalusi Anikó (1968-) (gyermekorvos, laboratóriumi szakorvos) Szerafin László (1958-) (belgyógyászat, haematológia, klinikai onkológia szakorvos) Muszbek László (1942-) (haematológus, kutató orvos) Kappelmayer János (1960-) (laboratóriumi szakorvos)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Celluláris hematológia - immunológia
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A véralvadás XIII-as faktorának (FXIII) struktúrája, funkciója, előfordulása egyéb testnedvekben és kapcsolata trombotikus megbetegedésekkel
Internet cím:DOI
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