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001-es BibID:	BIBFORM040836
Első szerző:	Weber, Irene T.
Cím:	HIV-1 protease and AIDS therapy / Irene T. Weber, Ying Zhang, József Tőzsér
Dátum:	2009
Megjegyzések:	Infection with HIV-1 causes the pandemic disease of AIDS in an estimated 30 million people. The viral protease has proved a successful target for AIDS therapy, and current effective therapy uses a selection from eight protease inhibitors in combination with other antiviral drugs. The antiviral protease inhibitors were developed over the past 15 years based on knowledge of the molecular structure of the protease, its substrate specificity and the mode of binding of inhibitors. Today, drug resistance has become a major challenge in AIDS therapy. Consequently, in the combat against drug resistance new antiviral protease inhibitors are being developed from structure-guided designs. These new drugs, such as darunavir, demonstrate high affinity binding to resistant mutants of HIV protease, and provide high genetic barriers to resistance. Recent developments are described in these structure-guided designs for antiviral therapy based on targeting the HIV-1 protease and its drug resistant mutants. Viral Proteases and Antiviral Protease Inhibitor Therapy Viral Proteases and Antiviral Protease Inhibitor Therapy Look Inside Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn Other actions Export citations About this Book
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet
Megjelenés:	Viral Proteases and Antiviral Protease Inhibitor Therapy. Proteases in Biology and Disease Vol. 8 / eds. Lendeckel, U., Hooper, N. M. - p. 25-45
További szerzők:	Zhang, Ying Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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