CCL

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1.

001-es BibID:BIBFORM034608
035-os BibID:PMID:2133212
Első szerző:Hársfalvi Jolán (klinikai biokémikus)
Cím:The use of polybrene for heparin neutralization in protein C activity assay / J. Harsfalvi, G. Pfliegler, M. Udvardy, Z. Boda, I. Tornai, K. Rak
Dátum:1990
ISSN:0957-5235
Megjegyzések:The protein C activity assay of Francis and Patch (Thromb Res 1983; 32: 605-613) is based on the prolongation of the activated partial thromboplastin time in the presence of activated protein C isolated from the test samples. The assay was modified and standardized by Rapaport et al. (Am J Clin Pathol 1987; 87: 491-497), but could still only be used in patients on heparin therapy after chromatographic removal of the heparin. In this study we attempted to eliminate the heparin separation step without losing the advantages of the modified (Rapaport) method. Heparin was added to the isolated protein C to obtain a rapid and complete antithrombin effect after the thrombin activation step and polybrene was subsequently used to neutralize the excess heparin. Using this modified assay protein C activity ranged from 67 to 133% in the normal population, and from 9 to 25% in coumarin-treated patients. Precision of the modified method was acceptable in both normal and pathological PC ranges: within- and between-batch variations were 5.6 and 3.6%, and 8 and 14%, respectively. The assay correlated well (r = 0.84) with the ELISA technique in both healthy donors and non-coumarin-treated patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Protein C assay
protein C deficiency
thrombosis
anticoagulant therapy
egyetemen (Magyarországon) készült közlemény
Megjelenés:Blood Coagulation & Fibrinolysis. - 1 : 4-5 (1990), p. 357-361. -
További szerzők:Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos) Udvardy Miklós (1947-) (belgyógyász, haematológus) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Rák Kálmán (1929-2005) (belgyógyász, klinikai hematológus, véralvadás kutató)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:bibEBI00018588
Első szerző:Pósán Emőke (belgyógyász, kardiológus)
Cím:Thrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head / Posan E., Szepesi K., Gáspár L., Csernátony Z., Hársfalvi J., Ajzner É., Tóth A., Udvardy M.
Dátum:2003
Megjegyzések:Recent reports seem to support the role of the thrombophilia and decreased fibrinolysis in the aetiopathogenesis of aseptic necrosis of bone. In the present study, haemostatic disturbances were analysed in adults (n = 49) and patients in childhood (Perthes disease) (n = 47) with aseptic necrosis of the femoral head. Fibrinolytic parameters (in vitro clot lysis, plasminogen, plasmatic plasminogen activator inhibitor-1 activity, D-dimer) along with lipoprotein (a) [Lp(a)] and fibrinogen were measured. von Willebrand factor, platelet activation and some thrombophilic factors (activated protein C resistance and factor V Leiden mutation, protein C, protein S activity) were also determined. Impaired fibrinolysis, an increased Lp(a) level along with slow clot lysis and increased platelet activation were found in adult cases. We detected five cases of factor V Leiden mutations (one heterozygotic and four homozygotic) among patients with Perthes disease. The clinical course of the heterozygous case was similar to the usual form of Perthes disease. The most severe form of Perthes disease has been observed in homozygous factor V Leiden mutation cases. The mutation of factor V Leiden per se probably does not induce the development of aseptic necrosis of bone tissue in childhood, but it does play a role in its acceleration. Homozygous factor V Leiden mutation definitely runs a more severe course. On the other hand, in adult cases, the disturbances of haemostasis, impaired fibrinolysis, elevated Lp(a) level, increased platelet activation and slight elevation of fibrinogen might have clinical relevance. Further studies should focus on proving the role of the haemostatic alterations in the pathogenesis of severe forms of aseptic bone necrosis. The use of antithrombotic drugs in order to slow the process of aseptic necrosis also has to be addressed in future surveys.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Blood Coagulation and Fibrinolysis. - 14 : 3 (2003), p. 243-248. -
További szerzők:Szepesi Kálmán (1938-) (ortopéd sebész) Gáspár Levente (1948-) (ortopéd és baleseti sebész) Csernátony Zoltán (1959-2023) (ortopéd sebész, traumatológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Ajzner Éva (1968-) (laboratóriumi szakorvos) Tóth Anikó Udvardy Miklós (1947-) (belgyógyász, haematológus)
Internet cím:DOI
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3.

001-es BibID:BIBFORM035432
035-os BibID:PMID:8054463
Első szerző:Udvardy Miklós (belgyógyász, haematológus)
Cím:Cyclic relapses of thrombotic thrombocytopenic purpura / M. Udvardy, I. Borka, K. Racz, J. Harsfalvi, Z. Boda, K. Rak
Dátum:1994
ISSN:0957-5235
Megjegyzések:A 24-year-old male patient was first observed with full-blown acute thrombotic thrombocytopenic purpura in 1991. Complete remission was achieved with plasma and plasmapheresis therapy, but in spite of continuous corticosteroid and aspirin administration, thrombocytopenic (megakaryocytic) relapses were observed every 26-30 days. Splenectomy and danazol failed to prevent the recurrence of the disease. Surprisingly, cyclosporin A (5 mg/kg/day) administration resulted in a complete transitional remission, but after dose reduction a less regular pattern of repeated milder recurrences was observed. Cryopreserved plasma, obtained from the patient during remission also proved to be effective in treating the last two thrombocytopenic episodes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
chronic relapsing thrombotic thrombocytopenic purpura (TTP)
Cyclosporin-A
plasmapheresis
egyetemen (Magyarországon) készült közlemény
Megjelenés:Blood Coagulation & Fibrinolysis. - 5 : 2 (1994), p. 305-307. -
További szerzők:Borka I. (Kecskemét) Rácz K. (belgyógyász) Hársfalvi Jolán (1949-) (klinikai biokémikus) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus) Rák Kálmán (1929-2005) (belgyógyász, klinikai hematológus, véralvadás kutató)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:bibEBI00018625
Első szerző:Udvardy Miklós (belgyógyász, haematológus)
Cím:Succesful control of massive coumarol induced acute upper GI bleeding and correction of prothrombin time by recombinant active Factor VII (Eptacog-alpha, NovoSeven) in a patient with a prosthetic aortic valve and two malignancies (chronic límphoid leukaemia and lung cancer) / Udvardy, M., Telek, B., Mezey, G., Batár, P., Altorjay, I.
Dátum:2004
Megjegyzések:Severe, life-threatening acute upper gastrointestinal bleeding may occasionally occur in patients receiving coumarol prophylaxis for prosthetic heart valves. These patients are exposed to two potential, serious risks: bleeding due to the severe blood loss induced by excessive anticoagulant effect or as a consequence of the cessation of anticoagulation subsequent thrombotic occlusion of the valve and loss of patency. Herein a short case report is presented. The elderly male patient had a prosthetic valve in the aortic position and also suffered from two malignant diseases: chronic lymphocytic leukaemia and a more recently developed lung cancer with metastatic spread into both lungs. The patient had a major gastrointestinal bleed, leading to a sudden fall of haematocrit (0.09), and to a collapse of peripheral circulation due to too excessive a coumarol effect (International Normalized Ratio > 8). An acute left ventricular failure developed during the early period of the emergency blood transfusion, so the correction of prothrombin time by fresh-frozen plasma (due to the large volume requirement) was not feasible. The patient received 50 microg/kg intravenous bolus of NovoSeven (recombinant active factor VII) in an almost desperate situation. The International Normalized Ratio changed to 2.1 in 30 min; bleeding had stopped immediately. There was neither evidence of disseminated intravascular coagulation (in spite of the age and underlying diseases) nor loss of valve patency or infective endocarditis during follow-up. This modest report may call attention to the potential use of recombinant active factor VII in the coumarol-induced severe bleeding episodes of prosthetic heart valve patients.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Blood Coagulation and Fibrinolysis. - 15 : 3 (2004), p. 265-267. -
További szerzők:Telek Béla (1948-) (belgyógyász, haematológus) Mezei Gabriella (1969-) (belgyógyász) Batár Péter (1969-) (belgyógyász, haematológus) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus)
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5.

001-es BibID:bibKLT00005075
Első szerző:Udvardy Miklós (belgyógyász, haematológus)
Cím:New pentamidine related substances which simultaneously inhibit platelet aggregation and accelerate plasmin generation and in vitro clot lysis / M. Udvardy, E. Posan, J. Hársfalvi, Z. Dinya
Dátum:1996
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Blood Coagulation and Fibrinolysis. - 7 : 2 (1996), 256-258. -
További szerzők:Pósán Emőke (1963-) (belgyógyász, kardiológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Dinya Zoltán (1942-) (vegyész)
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