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001-es BibID:	BIBFORM040065
Első szerző:	Benyó Mátyás (urológus)
Cím:	Follow-Up of Thrombin Generation after Prostate Cancer Surgery : Global Test for Increased Hypercoagulability / Matyas Benyo, Tibor Flasko, Zsuzsanna Molnar, Adrienne Kerenyi, Zoltan Batta, Tamas Jozsa, Jolan Harsfalvi
Dátum:	2012
ISSN:	1932-6203
Megjegyzések:	Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these processes providing sufficient evaluation of an individual's hemostatic competence and response to anticoagulant therapy. The objective of the study is to assess a new measure of hypercoagulability that predisposes to venous thromboembolism in the postoperative period after radical prostatectomy. Pre- (day-1) and postoperative (hour 1, day 6, month 1 and 10) blood samples of 24 patients were tested for plasma thrombin generation (peak thrombin), routine hematology and hemostasis. Patients received low molecular weight heparin for thromboprophylaxis. Peak thrombin levels were higher in patients compared to controls at baseline (p<0.001), and elevated further in the early postoperative period (p<0.001). Longer general anesthesia and high body mass index were associated with increased thrombin generation after surgery (p = 0.024 and p = 0.040). D dimer and fibrinogen levels were higher after radical prostatectomy (p = 0.001 and p<0.001). Conventional clotting tests remained within the reference range. Our study contributed to the cognition of the hypercoagulable state in cancer patients undergoing pelvic surgery and revealed the course of thrombin generation after radical prostatectomy. Whilst it is unsurprising that thrombin generation increases after tissue trauma, further evaluation of this condition during the postoperative period would lead urologists to an international and well-supported consensus regarding thromboprophylaxis in order to provide better clinical outcome. Considering the routine evaluation of procoagulant activity and extending prophylactic anticoagulant therapy accordingly may potentially prevent late thrombotic events.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Plos One. - 7 : 12 (2012), p. e51299. -
További szerzők:	Flaskó Tibor (1960-) (urológus) Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Batta Zoltán Józsa Tamás (1969-) (gyermeksebész, urológus) Hársfalvi Jolán (1949-) (klinikai biokémikus)
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001-es BibID:	BIBFORM033201
Első szerző:	Mendelboum Raviv, Shlomit (biológus)
Cím:	4-thio-deoxyuridylate modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growrth on subendothelial matrix / S. Mendelboum Raviv, A. Horváth, J. Aradi, Z. Bagoly, F. Fazakas, Z. Batta, L. Muszbek, J. Hársfalvi
Dátum:	2008
ISSN:	1538-7933
Megjegyzések:	Background:?The consensus thrombin aptamer C15-mer is a single-stranded DNA of 15 nucleotides [d(GGTTGGTGTGGTTGG)] that was identified by the selection of thrombin-binding molecules from a large combinatorial library of oligonucleotides. It is capable of inhibiting thrombin at nanomolar concentrations through binding to a specific region within thrombin exosite 1. As has been shown in our earlier studies, the 4-thio-deoxyuridylate (s4dU)-containing oligonucleotides have high affinity for a number of proteins, due to the reduced hydrophilic character of the modified oligonucleotide. Methods:?Three different analogs of the original thrombin-inhibiting sequence, in which some of the thymidylate residues were replaced by 4-thio-deoxyuridylates, were synthesized. The inhibitory effect of modified aptamers was tested on thrombin-catalyzed fibrin clot formation and fibrinopeptide A release from fibrinogen, thrombin-induced platelet aggregation/secretion, and the formation of thrombus on coverslips coated with human collagen type III, thrombin-treated fibrinogen or subendothelial matrix of human microvascular endothelial cells. Results:?As compared with the C15-mer, the analog with the sequence GG(s4dU)TGG(s4dU)G(s4dU)GGT(s4dU)GG (UC15-mer) showed a 2-fold increased inhibition of thrombin-catalyzed fibrin clot formation, fibrinopeptide A release, platelet aggregation and secretion in human plasma and thrombus formation on thrombin-treated fibrinogen surfaces under flow conditions. Concerning the inhibition of thrombin-induced fibrin formation from purified fibrinogen and activation of washed platelets, UC15-mer was 3-fold and twelve-fold more effective than C15-mer, respectively.Conclusion:?The replacement of four thymidylate residues in C15-mer by 4-thio-deoxyuridylate resulted in a new thrombin aptamer with increased anticoagulant and antithrombotic properties.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 4-thio-deoxyuridylate aptamer platelets thrombin thrombin exosite thrombus
Megjelenés:	Journal Of Thrombosis And Haemostasis. - 6 : 10 (2008), p. 1764-1771. -
További szerzők:	Horváth András (1976-) (vegyész) Aradi János (1942-) (biokémikus, vegyész) Bagoly Zsuzsa (1978-) (orvos) Fazakas Ferenc (1969-) (molekuláris biológus) Batta Zoltán Muszbek László (1942-) (haematológus, kutató orvos) Hársfalvi Jolán (1949-) (klinikai biokémikus)
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001-es BibID:	BIBFORM071315
Első szerző:	Selmeczi Anna (orvos)
Cím:	Thrombin generation and low-molecular-weight heparin prophylaxis in pregnant women with thrombophilia / Selmeczi Anna, Rachel E. J. Roach, Móré Csaba, Batta Zoltán, Hársfalvi Jolán, Anske Van de Bom, Boda Zoltán, Oláh Zsolt
Dátum:	2015
ISSN:	0340-6245
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Thrombosis and Haemostasis 113 : 2 (2015), p. 283-289. -
További szerzők:	Roach, Rachel E. J. Móré Csaba (1971-) (szülész-nőgyógyász) Batta Zoltán Hársfalvi Jolán (1949-) (klinikai biokémikus) Van de Bom, Anske Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus) Oláh Zsolt (1974-) (belgyógyász)
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