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001-es BibID:	BIBFORM048958
Első szerző:	Emri Tamás (biológus)
Cím:	Towards high-siderophore-content foods : optimisation of coprogen production in submerged cultures of Penicillium nalgiovense / Tamás Emri, Viktória Tóth, Csilla Terézia Nagy, Gábor Nagy, Imre Pócsi, Gyöngyi Gyémánt, Károly Antal, József Balla, György Balla, Gyula Román, István Kovács, István Pócsi
Dátum:	2013
ISSN:	0022-5142
Megjegyzések:	Background Fungal siderophores are likely to possess atheroprotective effects in humans, and therefore studies are needed to develop siderophore-rich food additives or functional foods to increase the siderophore uptake in people prone to cardiovascular diseases. In this study the siderophore contents of mould-ripened cheeses and meat products were analysed and the coprogen production by Penicillium nalgiovense was characterised. Results High concentrations of hexadentate fungal siderophores were detected in penicillia-ripened Camembert- and Roquefort-type cheeses and also in some sausages. In one sausage fermented by P. nalgiovense, the siderophore content was comparable to those found in cheeses. Penicillium nalgiovense produced high concentrations of coprogen in submerged cultures, which were affected predominantly by the available carbon and nitrogen sources under iron starvation. Considerable coprogen yields were still detectable in the presence of iron when the fermentation medium was supplemented with the iron chelator Na2-EDTA or when P. nalgiovense was co?cultivated with Saccharomyces cerevisiae. Conclusion These data may be exploitable in the future development of high?siderophore?content foods and/or food additives. Nevertheless, the use of P. nalgiovense fermentation broths for these purposes may be limited by the instability of coprogen in fermentation media and by the β-lactam production by the fungus.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Egészség- és Környezettudomány Doktori iskola atherosclerosis coprogen sausage Penicillium nalgiovense functional food β-lactam
Megjelenés:	Journal Of The Science Of Food And Agriculture. - 93 : 9 (2013), p. 2221-2228. -
További szerzők:	Tóth Viktória (1984-) (biológus) Nagy Csilla Terézia Szemán-Nagy Gábor (1975-) (biológia tanár-molekuláris biológus) Pócsi Imre Gyémánt Gyöngyi (1960-) (vegyész) Antal Károly (neurobiológus) Balla József (1959-) (belgyógyász, nephrológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Román Gyula Kovács István Pócsi István (1961-) (vegyész)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Mikrobiális genetika és genomika TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Juhász-Nagy Pál Doktori Iskola TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Gyermekgyógyászat Kutatócsoport OTKA-K75883 OTKA
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001-es BibID:	BIBFORM070541
Első szerző:	Malina Tamás (biológus)
Cím:	Individual variability of venom from the European adder (Vipera berus berus) from one locality in Eastern Hungary / Malina T., Krecsák L., Westerström A., Szemán-Nagy G., Gyémánt G., M-Hamvas M., Rowan E. G., Harvey A. L., Warrell D. A., Pál B., Rusznák Z., Vasas G.
Dátum:	2017
ISSN:	0041-0101
Megjegyzések:	We have revealed intra-population variability among venom samples from several individual European adders (Vipera berus berus) within a defined population in Eastern Hungary. Individual differences in venom pattern were noticed, both gender-specific and age-related, by one-dimensional electrophoresis. Gelatin zymography demonstrated that these individual venoms have different degradation profiles indicating varying protease activity in the specimens from adders of different ages and genders. Some specimens shared a conserved region of substrate degradation, while others had lower or extremely low protease activity. Phospholipase A2 activity of venoms was similar but not identical. Interspecimen diversity of the venom phospholipase A2-spectra (based on the components' molecular masses) was detected by MALDI-TOF MS. The lethal toxicity of venoms (LD50) also showed differences among individual snakes. Extracted venom samples had varying neuromuscular paralysing effect on chick biventer cervicis nerve-muscle preparations. The paralysing effect of venom was lost when calcium in the physiological salt solution was replaced by strontium; indicating that the block of twitch responses to nerve stimulation is associated with the activity of a phospholipase-dependent neurotoxin. In contrast to the studied V. b. berus venoms from different geographical regions so far, this is the first V. b. berus population discovered to have predominantly neurotoxic neuromuscular activity. The relevance of varying venom yields is also discussed. This study demonstrates that individual venom variation among V. b. berus living in particular area of Eastern Hungary might contribute to a wider range of clinical manifestations of V. b. berus envenoming than elsewhere in Europe.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Intra-species venom variation Neurotoxic Phospholipase A(2) Protease Vipera berus berus
Megjelenés:	Toxicon 135 (2017), p. 59-70. -
További szerzők:	Krecsák László Westerström, Alexander Szemán-Nagy Gábor (1975-) (biológia tanár-molekuláris biológus) Gyémánt Gyöngyi (1960-) (vegyész) Mikóné Hamvas Márta (1963-) (biológus) Rowan, Edward G. Harvey, Alan L. Warrell, David A. Pál Balázs (1975-) (élettanász) Rusznák Zoltán (1965-) (élettanász) Vasas Gábor (1975-) (biológus-vegyész)
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