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001-es BibID:	BIBFORM025174
Első szerző:	Biró Sándor (molekuláris genetikus)
Cím:	Cloning of Streptomyces griseus and Streptomyces lividans genes for glycerol dissimilation / S. Biró, K. F. Chater
Dátum:	1987
Megjegyzések:	Streptomyces lividans gyl DNA (for glycerol utilisation) was cloned by complementation of a Streptomyces coelicolor gyl mutant. Restriction mapping showed that the cloned DNA was highly homologous (perhaps 99%) to S. coelicolor gyl DNA. Using phage-mediated mutational cloning, an internal fragment of the S. coelicolor gyl operon was used to generate a gyl mutant of S. lividans, which subsequently served as recipient in the cloning of gyl DNA from S. griseus. A 7.5-kb SstI-generated fragment of S. griseus DNA was obtained which, as judged by analysis of restriction sites, was only perhaps 87% homologous with the S. coelicolor gyl operon. The cloned S. griseus DNA appears to contain intact gylA and gylB genes and probably also an upstream gene related to the putative gyl regulatory '0.9-kb' gene of S. coelicolor. Cloning of the fragment on a high-copy-number vector in S. lividans did not lead to high levels of the enzymes encoded by gylA and gylB. The S. griseus gylA and gylB genes were not detectably expressed in Escherichia coli glp mutants.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Gene. - 56 : 1 (1987), p. 79-86. -
További szerzők:	Chater, Keith F.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus változat
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001-es BibID:	BIBFORM025171
Első szerző:	Biró Sándor (molekuláris genetikus)
Cím:	The molecular genetics of glycerol utilisation in Streptomyces / S. Biró, C. P. Smith, K. F. Chater
Dátum:	1986
ISBN:	963 05 4395
Tárgyszavak:	Természettudományok Biológiai tudományok előadáskivonat
Megjelenés:	Biological, Biochemical and biological aspects of actinomycetes : Proceedings of the Sixth International Symposium on Actinomycetes Biology / eds. G. Szabó, S. Biró, M Goodfellow. - p. 117-120.
További szerzők:	Smith, Christopher P. Chater, Keith F.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM010402
Első szerző:	Chater, Keith F.
Cím:	The complex extracellular biology of Streptomyces / Keith F. Chater, Sándor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf
Dátum:	2010
ISSN:	0168-6445 (Print)
Megjegyzések:	Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have an exceptionally large number of predicted secreted proteins, including many exported via the twin-arginine transport system. Their use of noncatalytic substrate-binding proteins and hydrolytic enzymes to obtain soluble nutrients from carbohydrates such as chitin and cellulose enables them to interact with other organisms. Some of their numerous secreted proteases participate in developmentally significant extracellular cascades, regulated by inhibitors, which lead to cannibalization of the substrate mycelium biomass to support aerial growth and sporulation. They excrete many secondary metabolites, including important antibiotics. Some of these play roles in interactions with eukaryotes. Surprisingly, some antibiotic biosynthetic enzymes are extracellular. Antibiotic production is often regulated by extracellular signalling molecules, some of which also control morphological differentiation. Amphipathic proteins, assembled with the help of cellulose-like material, are required for both hyphal attachment to surfaces and aerial reproductive growth. Comparative genomic analysis suggests that the acquisition of genes for extracellular processes has played a huge part in speciation. The rare codon TTA, which is present in the key pleiotropic regulatory gene adpA and many pathway-specific regulatory genes for antibiotic production, has a particular influence on extracellular biology.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Tat system polysaccharide degradation protease cascade secondary metabolism extracellular signalling surface-active proteins
Megjelenés:	FEMS Microbiology Reviews. - 34 : 2 (2010), p. 171-198. -
További szerzők:	Biró Sándor (1949-) (molekuláris genetikus) Lee, Kye Joon Palmer, Tracy Schrempf, Hildgund
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001-es BibID:	BIBFORM005744
Első szerző:	Kiss Zsuzsanna (genetikus)
Cím:	Streptomyces griseus 45H, a producer of the extracellular autoregulator protein factor C, is a member of the species Streptomyces albidoflavus / Kiss Zsuzsanna, Ward Alan C., Birkó Zsuzsanna, Chater Keith F., Biró Sándor
Dátum:	2008
Megjegyzések:	Streptomyces griseus strain 45H, isolated in 1960 during a mutagenesis programme on the industrial streptomycin producer S. griseus 52-1, encodes an extracellular, pleiotropic autoregulatory signalling protein, factor C, which stimulates sporulation of S. griseus 52-1 in submerged culture. The facC gene, which codes for factor C, is present in very few streptomycetes and is not present in S. griseus 52-1. Based on 16S rRNA gene sequencing and other molecular data, S. griseus 45H, the factor C producer, is here shown to be related to the original laboratory strain of Streptomyces flavofungini, which was being studied in the same laboratory in 1960, and to Streptomyces albidoflavus. Southern blotting revealed that three out of four independently isolated strains of S. albidoflavus possess facC. Both the original strain of S. flavofungini and S. griseus 45H are therefore identified as members of the species Streptomyces albidoflavus, and we propose that S. griseus 45H should be renamed Streptomyces albidoflavus 45H.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban C-factor Strepromyces
Megjelenés:	International Journal of Systematic and Evolutionary Microbiology. - 58 : (Pt4) (2008), p. 1029-1031. -
További szerzők:	Ward, Alan C. Hádáné Birkó Zsuzsanna (1971-) (molekuláris genetikus) Chater, Keith F. Biró Sándor (1949-) (molekuláris genetikus)
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