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001-es BibID:BIBFORM066611
Első szerző:Máthé Csaba (biológus)
Cím:The Effects of microcystins (Cyanobacterial Heptapeptides) on the eukaryotic cytoskeletal system / Csaba Máthé, Dániel Beyer, Márta M-Hamvas, Gábor Vasas
Dátum:2016
ISSN:1389-5575 1875-5607
Megjegyzések:Microcystins (MCYs) are cyanobacterial heptapeptides known for their high toxicity ineukaryotic cells and for their potential human health hazards. They are potent and specific inhibitorsof type 1 and 2A, serine-threonine protein phosphatases (PP1 and PP2A) and as such, interfere withkey cellular and metabolic events. Moreover, they induce oxidative stress involving reactive oxygenspecies (ROS) generation. Their cytoskeletal effects involve both mitotic and differentiated eukaryoticcells. The main objective of the present review is to summarize the most important cytoskeletal effectsof MCY on human, animal and plant cells known to date and to give an insight into the cellular and molecular backgroundof these alterations. Disruptions of microtubule (MTs), microfilament (MF) and intermediate filament (IF) organizationhave all been described, having consequences on cell shape, tissue integrity and functionality and mitotic division. Mostof these subcellular changes are closely related to PP1 and PP2A inhibition and involve misfunctioning of cytoskeletonassociated proteins. However, several cytoskeletal alterations are likely to be related to the induction of oxidative stress.MCY induced changes in MT, MF and IF assembly may have severe human health consequences. The main target ofcyanotoxin in human/ animal cells is liver and cytoskeletal disruption alters structure and functioning of hepatocytes.However, many other cell types undergo alterations similar to those observed in hepatocytes. Both PP1/PP2A inhibitionand ROS generation are involved and the activation of mitogen activated protein kinases (MAPKs) seems to play a crucialrole in the molecular events leading to cytoskeletal disruption.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Intermediate filaments
microcystin
microfilaments
microtubules
oxidative stress
protein phosphatase
Megjelenés:Mini-Reviews in Medicinal Chemistry 16 : 13 (2016), p. 1063-1077. -
További szerzők:Beyer Dániel (1982-) (molekuláris biológus) Mikóné Hamvas Márta (1963-) (biológus) Vasas Gábor (1975-) (biológus-vegyész)
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001-es BibID:BIBFORM016072
Első szerző:Vasas Gábor (biológus-vegyész)
Cím:Alkaloids from Cyanobacteria with Diverse Powerful Bioactivities / Vasas, G., Borbely, G., Nanasi, P., Nanasi, P. P.
Dátum:2010
ISSN:1389-5575
Megjegyzések:Alkaloid containing plants represent a heterogeneous group both taxonomically and chemically, a basic nitrogen being the unifying factor for the various classes. As most alkaloids are extremely toxic, organisms containing them do not feature strongly in medicine but they have always been important in the allopathic system. Typical alkaloids are derived from plant sources, they are basic, they contain one or more nitrogen, and they usually have marked physiological actions in humans or other mammalian species. This review will present various alkaloids generated by cyanobacteria, highlighting their complex structures, powerful bioactivities, and pharmacological properties. The main groups of cyanobacterial alkaloids include the neuromuscular transmission blocker anatoxins, the ion channel blocker saxitoxins, the degenerated amino acid beta-methylamino-L-alanine, the protein synthesis inhibitor guanidine alkaloid cylindrospermopsins, and cyanobacterial indol alkaloids with antiviral, antifungal, and cytotoxic activity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Mini-Reviews in Medicinal Chemistry. - 10 : 10 (2010), p. 946-955. -
További szerzők:Borbély György (1943-) (biológus) Nánási Péter Pál (1923-2013) (biokémikus) Nánási Péter Pál (1956-) (élettanász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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