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001-es BibID:BIBFORM051859
Első szerző:Zsíros Noémi (belgyógyász)
Cím:The c.-133A >G polymorphism in NPC1L1 gene influences the efficacy of ezetimibe monotherapy on apolipoprotein A1 in hyperlipidemic patients / N. Zsíros, M. Bodor, V. Varga, E. Berta, I. Balogh, I. Seres, G. Paragh, M. Harangi
Dátum:2014
ISSN:0031-7144
Megjegyzések:Niemann-Pick C1-like 1 protein (NPC1L1) plays a critical role in intestinal cholesterol absorption. Previousstudies found that the NPC1L1 c.-133A >G SNP, but not other NPC1L1 SNPs, was associated withresponse to statin treatment and statin-ezetimibe combinations. To date effect of NPC1L1 c.-133A >G SNPon ezetimibe monotherapy has not been studied. Our objective was to examine whether SNP c.-133A >Gatthe NPC1L1 gene has effects on lipid levels and on the efficacy of 3, 6 and 12 months of 10mg daily ezetimibemonotherapy in hyperlipidemic patients with statin induced adverse effects. One hundred and one typeIIa and IIb hyperlipidemic patients (72 females, 29 males; age: 61.23?9.87 ys; BMI: 28.18?4.29 kg/m2)were enrolled. The genotype frequencies were conformed to Hardy-Weinberg equilibrium. We could notfind significant differences in initial lipid levels between AA and AG+GG patients. While plasma levels ofapolipoprotein A1 (ApoA1) did not significantly decrease after ezetimibe treatment (1.96; 3.39 and 2.74%)in AA patients, a significant elevation in ApoA1 levels has been found after treatment in AG+GG patients(9.15; 8.54 and 13.58%). The effect of NPC1L1 c.-133A >G on the ApoA1 levels was found significant(p < 0.05). Efficacy of treatment with ezetimibe on other plasma lipid parameters after 3, 6 or 12 months didnot differ significantly. NPC1L1 -133A >G SNP influences the ApoA1 response to ezetimibe monotherapy,therefore, may alter the effect of ezetimibe on the structure and function of the high-density lipoproteinparticles.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pharmazie 69 (2014), p. 1-6. -
További szerzők:Bodor Miklós (1969-) (belgyógyász, endokrinológus) Varga V. Berta E. Balogh István (1972-) (molekuláris biológus, genetikus) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0031
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