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001-es BibID:	BIBFORM024865
Első szerző:	Seres Ildikó (biokémikus)
Cím:	Age-related alterations in PON1 / I. Seres, T. Fulop, G. Paragh, A. Khalil
Dátum:	2008
Megjegyzések:	Aging is associated with an increased incidence of atherosclerosis. Atherosclerosis is an inflammatory disease initiated by oxidized low density lipoprotein (oxLDL). High density lipoprotein (HDL) is a powerful antioxidant protecting LDL and itself from oxidation as well by detoxifying the hydroperoxides from oxLDL. The enzyme responsible, at least in part, for this antioxidant effect of HDL is its tightly associated paraoxonase (PON1). As PON1 is responsible for the antioxidant effect of HDL and the atherosclerosis related cardiovascular diseases are increasing with aging an alteration either in the PON1 expression and/or activity should occur with aging. Indeed, PON1 serum concentrations do not change with aging while its activity significantly decreases. This chapter will describe the putative causes of this altered PON1 activity at the environmental and genetic levels. The possibility of PON1 activity modulation will be also discussed
Tárgyszavak:	Orvostudományok Klinikai orvostudományok könyvfejezet
Megjelenés:	The Paraoxonases : their role in disease development and xenobiotic metabolism / ed. by Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh. - p. 199-206. -
További szerzők:	Fülöp Tamás Jr Paragh György (1953-) (belgyógyász) Khalil, Abdelouahed
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM017665
Első szerző:	Seres Ildikó (biokémikus)
Cím:	Study of factors influencing the decreased HDL associated PON1 activity with aging / Seres Ildikó, Paragh György, Deschene Elaine, Fülöp Tamás, Khalil Abdelouahed
Dátum:	2004
ISSN:	0531-5565
Megjegyzések:	Paraoxonase (PON1) is principally complexed to HDL and is responsible, at least in part, for its antioxidant properties. PON1 activity decreases in several pathologies associated with atherosclerosis. The aim of this study was to investigate the PON1 activity and factors influencing its activity as a function of age. One hundred and twenty nine healthy subjects aged between 22 and 89 years were recruited for the study. We found that serum PON1 activity significantly decreased with age (r=-0.38, p<0.0001) while its arylesterase activity as well as its concentration in the serum did not change significantly. HDL concentrations remained unchanged with age, however, Apo A1 concentration showed a slight negative but significant correlation with age (r=-0.19, p<0.027). Moreover, the total cholesterol concentration was positively and significantly correlated with age (r=0.40, p<0.001). Thus, our results suggest that the decrease in PON1 activity cannot be explained by the decrease in Apo A1 concentrations with age. HDL from elderly subjects was more susceptible to oxidation than HDL from young subjects measured by higher lipid peroxidation rate. Thus, the decrease in PON1 activity may contribute to this increased susceptibility of HDL to oxidation with aging. Altogether our results suggest that the decrease in PON1 activity may be related to the development of oxidative stress conditions with aging and the increased HDL susceptibility to oxidation in elderly subjects.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Experimental Gerontology. - 39 : 1 (2004), p. 56-66. -
További szerzők:	Paragh György (1953-) (belgyógyász) Deschene, Elaine Fülöp Tamás Jr Khalil, Abdelouahed
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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