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1.

001-es BibID:BIBFORM020023
Első szerző:Elliott, Mark S. J.
Cím:Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition / Marc S. J. Elliott, Clive G. Ballard, Rajesh N. Kalaria, Robert Perry, Tibor Hortobágyi, Paul T. Francis
Dátum:2009
ISSN:0006-8950
Megjegyzések:Vascular dementia accounts for approximately 15-20% of all dementias. In addition, a significant subset of people with Alzheimer's disease have concurrent cerebrovascular disease. Vascular dementia is caused by different cerebrovascular morphological abnormalities including large artery territory infarction (multi-infarct vascular dementia) and sub-cortical ischaemic vascular dementia. Despite this distinction, there is a lack of studies examining the neurochemistry of individual vascular dementia subtypes. Serotonin is believed to play an important role in cognition, and serotonin receptors may provide a novel target for future anti-dementia therapeutics. This study aimed to determine levels of two serotonin receptors in subtypes of vascular dementia and relate any changes to cognition. We have determined, using saturation radioligand binding, the binding parameters (affinity and maximal binding) of ((3)H)-WAY 100635 binding to 5-HT(1A) receptors and ((3)H)-ketanserin binding to 5-HT(2A) receptors in post-mortem tissue from the frontal and temporal cortices of patients with either multi-infarct vascular dementia, sub-cortical ischaemic vascular dementia, mixed Alzheimer's disease/vascular dementia or stroke no dementia (SND). 5-HT(1A) and 5-HT(2A) receptor binding was significantly increased in the temporal cortex of patients with either multi-infarct vascular dementia or SND, compared to age-matched controls. 5-HT(1A) receptor maximal binding in the temporal cortex was also positively correlated with cognition as determined by Mini-Mental State Examination (MMSE) and Cambridge Assessment of Mental Health for the Elderly scores (CAMCOG). These results reveal an important distinction between the neurochemistry of multi-infarct vascular dementia/SND and sub-cortical ischaemic vascular dementia, suggesting that pharmacological manipulation of serotonin offers the possibility to develop novel therapies for stroke and multi-infarct vascular dementia patients. The results also highlight the importance of the cortical 5-HT(1A) receptor in mediating cognition.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain. - 132 : 7 (2009), p. 1858-1865. -
További szerzők:Ballard, Clive G. Kalaria, Rajesh N. Perry, Robert Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
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2.

001-es BibID:BIBFORM016360
Első szerző:Kirvell, S. L.
Cím:Vesicular glutamate transporter and cognition in stroke : a case-control autopsy study / S. L. Kirvell, M. S. Elliott, R. N. Kalaria, T. Hortobágyi, C. G. Ballard, P. T. Francis
Dátum:2010
ISSN:0028-3878
Megjegyzések:OBJECTIVES: Vascular dementia (VaD) accounts for approximately 15%-20% of all dementias, but the relationship of progressive cognitive impairment to neurochemical changes is poorly understood. We have therefore investigated glutamatergic synaptic markers in VaD. METHODS: We used homogenates prepared from gray matter from 2 neocortical regions (Brodmann area [BA] 9 and BA 20) and Western blotting to determine the concentrations of key components of the glutamatergic neurotransmitter system, vesicular glutamate transporter 1 (VGLUT1) and excitatory amino acid transporter EAAT2 (GLT-1), and the ubiquitous synaptic protein, synaptophysin, in 73 individuals-48 patients with cerebrovascular disease with and without dementia, 10 patients with AD, and 15 controls-in a case-control design. RESULTS: VGLUT1 concentrations in BA 20 and BA 9 were correlated with CAMCOG total (Rs 0.525, p = 0.018, n = 20; Rs 0.560, p = 0.002, n = 27) and CAMCOG memory scores (Rs 0.616, p = 0.004, n = 20; Rs 0.675, p = 0.000, n = 27). VGLUT1 concentration in BA 9 differed between the different dementia groups and the stroke no dementia group (1-way analysis of variance F = 6.69, p = 0.001 and Bonferroni p < 0.01 in each case), with subjects with stroke who did not develop dementia exhibiting the highest mean value for VGLUT1. CONCLUSIONS: These data suggest that loss of glutamatergic synapses is a feature of VaD and Alzheimer disease but the preservation of synapses, in particular glutamatergic synapses, in the frontal cortex against the temporal cortex plays a role in sustaining cognition and protecting against dementia following a stroke.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 75 : 20 (2010), p. 1803-1809. -
További szerzők:Elliott, Mark S. J. Kalaria, Rajesh N. Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Francis, Paul T.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM065659
Első szerző:McAleese, Kirsty E.
Cím:Post-mortem assessment in vascular dementia : advances and aspirations / Kirsty E. McAleese, Irina Alafuzoff, Andreas Charidimou, Jacques De Reuck, Lea T. Grinberg, Atticus H. Hainsworth, Tibor Hortobagyi, Paul Ince, Kurt Jellinger, Jing Gao, Raj N. Kalaria, Gabor G. Kovacs, Enikö Kövari, Seth Love, Mara Popovic, Olivia Skrobot, Ricardo Taipa, Dietmar R. Thal, David Werring, Stephen B. Wharton, Johannes Attems
Dátum:2016
ISSN:1741-7015
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:BMC Medicine 14 : 1 (2016), p. 1-16. -
További szerzők:Alafuzoff, Irina Charidimou, Andreas De Reuck, Jacques Grinberg, Lea T. Hainsworth, Atticus H. Hortobágyi Tibor (1965-) (patológus) Ince, Paul Jellinger, Kurt Gao, Jing Kalaria, Rajesh N. Kovács Gábor Géza (1969-) (neurológus) Kővári Enikő Love, Seth Popovic, Mara Skrobot, Olivia A. Taipa, Ricardo Thal, Dietmar R. Werring, David Wharton, Stephen B. Attems, Johannes
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4.

001-es BibID:BIBFORM020047
Első szerző:Mulugeta, Ezra
Cím:Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia / Ezra Mulugeta, Francisco Molina-Holgado, Mark S. Elliott, Tibor Hortobagyi, Robert Perry, Rajesh N. Kalaria, Clive G. Ballard, Paul T. Francis
Dátum:2008
ISSN:1420-8008
Megjegyzések:Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin (IL)-1beta, IL-1alpha, IL-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the status of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dementia and Geriatric Cognitive Disorders. - 25 : 3 (2008), p. 278-286. -
További szerzők:Molina-Holgado, Francisco Elliott, Mark S. J. Hortobágyi Tibor (1965-) (patológus) Perry, Robert Kalaria, Rajesh N. Ballard, Clive G. Francis, Paul T.
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5.

001-es BibID:BIBFORM020018
Első szerző:Sharp, Sally I.
Cím:Choline acetyltransferase activity in vascular dementia and stroke / Sally I. Sharp, Paul T. Francis, Mark S. J. Elliott, Rajesh N. Kalaria, Natasha Bajic, Tibor Hortobagyi, Clive G. Ballard
Dátum:2009
ISSN:1420-8008
Megjegyzések:BACKGROUND/AIM: Alterations in cholinergic activity have not been systematically studied in types of cerebrovascular disease. We examined cholinergic function at postmortem, focussing on stroke and vascular dementia (VaD). METHODS: Post-mortem brain tissue was studied from 61 patients with stroke or VaD (13 infarct dementia; 8 stroke/no dementia; 11 sub-cortical ischaemic VaD, SIVD; 29 VaD and concurrent Alzheimer's disease, AD), 12 patients with AD and 23 controls. Choline acetyltransferase (ChAT) was measured in Brodmann areas (BA) 9 and 20/21. RESULTS: There were significant reductions in ChAT activity in patients with VaD and concurrent AD compared to age-matched controls (BA9: t = 2.7, p = 0.009; BA20/21: t = 4.67, p = 0.000). In patients with infarct dementia, there was a significant 27% increase in ChAT activity in BA9 (t = 2.1, p = 0.047), but not in BA20/21 (t = 1.67, p = 0.106), compared to the age-matched control group. There was no relationship between ChAT activity and cognition in the VaD patients. CONCLUSIONS: Loss of cholinergic function is only evident in VaD patients with concurrent AD. A novel increase in cholinergic activity was identified in patients with infarct dementia, which may create important new treatment opportunities.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dementia and Geriatric Cognitive Disorders. - 28 : 3 (2009), p. 233-238. -
További szerzők:Francis, Paul T. Elliott, Mark S. J. Kalaria, Rajesh N. Bajic, Natasha Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G.
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6.

001-es BibID:BIBFORM067303
Első szerző:Skrobot, Olivia A.
Cím:Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline / Olivia A. Skrobot, Johannes Attems, Margaret Esiri, Tibor Hortobágyi, James W. Ironside, Rajesh N. Kalaria, Andrew King, G. A. Lammie, David Mann, James Neal, Yoav Ben-Shlomo, P. G. Kehoe, Seth Love
Dátum:2017
ISSN:0006-8950
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Brain. - 140 : 2 (2017), p. e13. -
További szerzők:Attems, Johannes Esiri, M. M. Hortobágyi Tibor (1965-) (patológus) Ironside, James W. Kalaria, Rajesh N. King, Andrew Lammie, George A. Mann, David J. Neal, James Ben-Shlomo, Yoav Kehoe, Patrick G. Love, Seth
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7.

001-es BibID:BIBFORM065465
Első szerző:Skrobot, Olivia A.
Cím:Vascular cognitive impairment neuropathology guidelines (VCING) : the contribution of cerebrovascular pathology to cognitive impairment / Olivia A. Skrobot, Johannes Attems, Margaret Esiri, Tibor Hortobágyi, James W. Ironside, Rajesh N. Kalaria, Andrew King, George A. Lammie, David Mann, James Neal, Yoav Ben-Shlomo, Patrick G. Kehoe, Seth Love
Dátum:2016
ISSN:0006-8950
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain 139 : 11 (2016), p. 2957-2969. -
További szerzők:Attems, Johannes Esiri, M. M. Hortobágyi Tibor (1965-) (patológus) Ironside, James W. Kalaria, Rajesh N. King, Andrew Lammie, George A. Mann, David J. Neal, James Ben-Shlomo, Yoav Kehoe, Patrick G. Love, Seth
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