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1.

001-es BibID:BIBFORM069190
Első szerző:Alghamdi, Amani
Cím:Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia / Alghamdi Amani, Vallortigara Julie, Howlett David R., Broadstock Martin, Hortobágyi Tibor, Ballard Clive, Thomas Alan J., O'Brien John T., Aarsland Dag, Attems Johannes, Francis Paul T., Whitfield David R.
Dátum:2017
ISSN:1387-2877
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Alzheimers Disease 57 : 2 (2017), p. 373-386. -
További szerzők:Vallortigara, Julie Howlett, David R. Broadstock, Martin Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Attems, Johannes Francis, Paul T. Whitfield, David
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2.

001-es BibID:BIBFORM082386
035-os BibID:(WoS)000528101100002 (Scopus)85084051209
Első szerző:Ashton, Nicholas J.
Cím:An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders / Nicholas J. Ashton, Abdul Hye, Anto P. Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas K. Karikari, Michael Schöll, Renaud La Joie, Gil D. Rabinovici, Kina Höglund, Clive Ballard1, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Dátum:2020
ISSN:1471-003X 1471-0048
Megjegyzések:In recent years, there has been an increasing emphasis on the importance of blood-based biomarkers in the first-in-line evaluation of patients with suspected neurodegenerative disorders (NDD). While neuroimaging (structural and molecular) and cerebrospinal fluid (CSF) analyses identify the underlying pathophysiology at the earliest stage, a biologically relevant marker derived from blood would have greater utility in the primary care setting and in the early screening for eligibility for therapeutic trials. The rapid advancement of ultra-sensitive assays has enabled the investigation of pathological proteins to be measured in blood samples, but research has been predominately focused on Alzheimer's disease (AD) cohorts. Nonetheless, proteins that are currently under scrutiny as blood biomarker candidates for AD (amyloid-?, tau and neurofilament light chain) are likely to have importance for Lewy body dementia's (LBD), frontotemporal dementia's (FTD) and other NDDs in terms of shared pathologies, similar degenerative processes or in the differential diagnosis of clinical symptoms. This review gives an overview and update on the current state of blood-based biomarkers for non-AD NDD, focusing on how candidate AD and novel biomarkers perform in these populations. As background information, we also briefly outline the neuropathological, clinical, molecular imaging and CSF features of the most common NDDs outside of the AD continuum.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nature Reviews Neuroscience. - 16 : 5 (2020), p. 265-284. -
További szerzők:Hye, Abdul Rajkumar, Anto P. Leuzy, Antoine Snowden, Stuart Suárez-Calvet, Marc Karikari, Thomas K. Schöll, Michael La Joie, Renaud Rabinovici, Gil D. Höglund, Kina Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Svenningsson, Per Blennow, Kaj Zetterberg, Henrik Aarsland, Dag
Pályázati támogatás:(2017-1.2.1-NKP-2017-00002)
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3.

001-es BibID:BIBFORM029486
Első szerző:Auning, Eirik
Cím:Early and presenting symptoms of dementia with lewy bodies / Eirik Auning, Arvid Rongve, Tormod Fladby, Jan Booij, Tibor Hortobágyi, Francoise J. Siepel, Clive Ballard, Dag Aarsland
Dátum:2011
ISSN:1420-8008
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dementia And Geriatric Cognitive Disorders. - 32 : 3 (2011), p. 202-208. -
További szerzők:Rongve, Arvid Fladby, Tormod Booij, Jan Hortobágyi Tibor (1965-) (patológus) Siepel, Francoise J. Ballard, Clive G. Aarsland, Dag
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4.

001-es BibID:BIBFORM063502
Első szerző:Baek, Jean-Ha
Cím:Unfolded protein response is activated in Lewy body dementias / J.-H. Baek, D. Whitfield, D. Howlett, P. Francis, E. Bereczki, C. Ballard, T. Hortobágyi, J. Attems, D. Aarsland
Dátum:2016
ISSN:0305-1846
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuropathology And Applied Neurobiology 42 : 4 (2016), p. 352-365. -
További szerzők:Whitfield, David Howlett, David R. Francis, Paul T. Bereczki Erika Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Attems, Johannes Aarsland, Dag
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5.

001-es BibID:BIBFORM071437
Első szerző:Bereczki Erika
Cím:Synaptic markers of cognitive decline in neurodegenerative diseases : a proteomic approach / Erika Bereczki, Rui M. Branca, Paul T. Francis, Joana B. Pereira, Jean-Ha Baek, Tibor Hortobágyi, Bengt Winblad, Clive Ballard, Janne Lehtiö, Dag Aarsland
Dátum:2017
ISSN:0006-8950
Megjegyzések:See Attems and Jellinger (doi:10.1093/brain/awx360) for a scientific commentary on this article.Cognitive changes occurring throughout the pathogenesis of neurodegenerative diseases are directly linked to synaptic loss. We used in-depth proteomics to compare 32 post-mortem human brains in the prefrontal cortex of prospectively followed patients with Alzheimer's disease, Parkinson's disease with dementia, dementia with Lewy bodies and older adults without dementia. In total, we identified 10 325 proteins, 851 of which were synaptic proteins. Levels of 25 synaptic proteins were significantly altered in the various dementia groups. Significant loss of SNAP47, GAP43, SYBU (syntabulin), LRFN2, SV2C, SYT2 (synaptotagmin 2), GRIA3 and GRIA4 were further validated on a larger cohort comprised of 92 brain samples using ELISA or western blot. Cognitive impairment before death and rate of cognitive decline significantly correlated with loss of SNAP47, SYBU, LRFN2, SV2C and GRIA3 proteins. Besides differentiating Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease from controls with high sensitivity and specificity, synaptic proteins also reliably discriminated Parkinson's disease dementia from Alzheimer's disease patients. Our results suggest that these particular synaptic proteins have an important predictive and discriminative molecular fingerprint in neurodegenerative diseases and could be a potential target for early disease intervention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain 141 : 2 (2018), p. 582-595. -
További szerzők:Branca, Rui M. Francis, Paul T. Pereira, Joana B. Baek, Jean-Ha Hortobágyi Tibor (1965-) (patológus) Winblad, Bengt Ballard, Clive G. Lehtiö, Janne Aarsland, Dag
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6.

001-es BibID:BIBFORM063546
Első szerző:Bereczki Erika
Cím:Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia / Erika Bereczki, Paul T. Francis, David Howlett, Joana B. Pereira, Kina Höglund, Anna Bogstedt, Angel Cedazo-Minguez, Jean-Ha Baek, Tibor Hortobágyi, Johannes Attems, Clive Ballard, Dag Aarsland
Dátum:2016
ISSN:0893-0341
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Alzheimers & Dementia 12 : 11 (2016), p. 1149-1158. -
További szerzők:Francis, Paul T. Howlett, David R. Pereira, Joana B. Höglund, Kina Bogstedt, Anna Cedazo-Minguez, Angel Baek, Jean-Ha Hortobágyi Tibor (1965-) (patológus) Attems, Johannes Ballard, Clive G. Aarsland, Dag
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7.

001-es BibID:BIBFORM020023
Első szerző:Elliott, Mark S. J.
Cím:Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition / Marc S. J. Elliott, Clive G. Ballard, Rajesh N. Kalaria, Robert Perry, Tibor Hortobágyi, Paul T. Francis
Dátum:2009
ISSN:0006-8950
Megjegyzések:Vascular dementia accounts for approximately 15-20% of all dementias. In addition, a significant subset of people with Alzheimer's disease have concurrent cerebrovascular disease. Vascular dementia is caused by different cerebrovascular morphological abnormalities including large artery territory infarction (multi-infarct vascular dementia) and sub-cortical ischaemic vascular dementia. Despite this distinction, there is a lack of studies examining the neurochemistry of individual vascular dementia subtypes. Serotonin is believed to play an important role in cognition, and serotonin receptors may provide a novel target for future anti-dementia therapeutics. This study aimed to determine levels of two serotonin receptors in subtypes of vascular dementia and relate any changes to cognition. We have determined, using saturation radioligand binding, the binding parameters (affinity and maximal binding) of ((3)H)-WAY 100635 binding to 5-HT(1A) receptors and ((3)H)-ketanserin binding to 5-HT(2A) receptors in post-mortem tissue from the frontal and temporal cortices of patients with either multi-infarct vascular dementia, sub-cortical ischaemic vascular dementia, mixed Alzheimer's disease/vascular dementia or stroke no dementia (SND). 5-HT(1A) and 5-HT(2A) receptor binding was significantly increased in the temporal cortex of patients with either multi-infarct vascular dementia or SND, compared to age-matched controls. 5-HT(1A) receptor maximal binding in the temporal cortex was also positively correlated with cognition as determined by Mini-Mental State Examination (MMSE) and Cambridge Assessment of Mental Health for the Elderly scores (CAMCOG). These results reveal an important distinction between the neurochemistry of multi-infarct vascular dementia/SND and sub-cortical ischaemic vascular dementia, suggesting that pharmacological manipulation of serotonin offers the possibility to develop novel therapies for stroke and multi-infarct vascular dementia patients. The results also highlight the importance of the cortical 5-HT(1A) receptor in mediating cognition.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain. - 132 : 7 (2009), p. 1858-1865. -
További szerzők:Ballard, Clive G. Kalaria, Rajesh N. Perry, Robert Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
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8.

001-es BibID:BIBFORM022141
Első szerző:Fritze, Friederike
Cím:Depressive symptoms in Alzheimer's disease and Lewy body dementia : a one-year follow-up study / Friederike Fritze, Uwe Ehrt, Tibor Hortobagyi, Clive Ballard, Dag Aarsland
Dátum:2011
ISSN:1420-8008
Megjegyzések:Objective: To explore the course of depression in people with mild dementia and identify predictors for depression at 1-year follow-up. Methods: Patients with mild dementia (n = 199) were assessed using Montgomery and Åsberg Depression Rating Scale (MADRS) and the depression item from Neuropsychiatric Inventory (NPI) at baseline and after 1 year. A score above 6 on MADRS indicates at least mild depression. Linear and logistic regression analyses were performed to identify predictors of change in depression scores. Results: Among subjects with depression at baseline, 68.1% remained depressed at follow-up, whereas 31.9% had remitted, based on MADRS. Among patients without depression at baseline, 77.1% remained non-depressed at follow-up, whereas 22.9% had incident depression. The proportion with persistent depression was higher in the combined dementia with Lewy bodies (DLB)/Parkinson's disease with dementia (PDD) group (45.5%) compared to AD (28%) (p < 0.05). Greater decline on the Mini Mental State Examination (p < 0.001) and higher baseline MADRS score (p < 0.001) were significant predictors of increased MADRS score. Conclusion: Two thirds of patients with depression at baseline were still depressed at follow-up, more so in DLB with PDD compared to AD. Cognitive decline was associated with worsening of depressive symptoms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dementia and Geriatric Cognitive Disorders. - 32 : 2 (2011), p. 143-149. -
További szerzők:Ehrt, Uwe Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Aarsland, Dag
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9.

001-es BibID:BIBFORM020291
Első szerző:Fritze, Friederike
Cím:Depression in mild dementia : associations with diagnosis, APOE genotype and clinical features / Friederike Fritze, Uwe Ehrt, Hogne Sønnesyn, Martin Kurz, Tibor Hortobágyi, Sabine Piepenstock Nore, Clive Ballard, Dag Aarsland
Dátum:2011
ISSN:0885-6230
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal of Geriatric Psychiatry. - 26 : 10 (2011), p. 1054-1061. -
További szerzők:Ehrt, Uwe Sønnesyn, Hogne Kurz, Martin Hortobágyi Tibor (1965-) (patológus) Nore, Sabine Piepenstock Ballard, Clive G. Aarsland, Dag
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10.

001-es BibID:BIBFORM063676
Első szerző:Howlett, David R.
Cím:Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias / David R. Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T. O'Brien, Dag Aarsland, Mitchell K.P. Lai, Jasinda H. Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T. Francis
Dátum:2015
ISSN:1015-6305
Megjegyzések:Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterizedby the presence of ?-synuclein-containing Lewy bodies and Lewy neurites.However, both dementias also show variable degrees of Alzheimer's disease (AD) pathology(senile plaques and neurofibrillary tangles), particularly in areas of the cortex associatedwith higher cognitive functions. This study investigates the contribution of theindividual and combined pathologies in determining the rate of cognitive decline. Cortical?-synuclein, phosphorylated tau (phosphotau) and A? plaque pathology in 34 PDD and 55DLB patients was assessed semi-quantitatively in four regions of the neocortex. The declinein cognition, assessed by Mini Mental State Examination, correlated positively with thecortical ?-synuclein load. Patients also had varying degrees of senile A? plaque andphosphotau pathology. Regression analyses pointed to a combined pathology (A? plaqueplus phosphotau plus ?-synuclein-positive features), particularly in the prefrontal cortex(BA9) and temporal lobe neocortex with the superior and middle temporal gyrus (BA21,22), being a major determining factor in the development of dementia. Thus, cognitivedecline in Lewy body dementias is not a consequence of ?-synuclein-induced neurodegenerationalone but senile plaque and phosphorylated tau pathology also contribute tothe overall deficits.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Pathology. - 25 : 4 (2015), p. 401-408. -
További szerzők:Whitfield, David Johnson, Mary Attems, Johannes O'Brien, John Aarsland, Dag Lai, Mitchell K.P. Lee, Jasinda H. Chen, Christopher Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
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11.

001-es BibID:BIBFORM016360
Első szerző:Kirvell, S. L.
Cím:Vesicular glutamate transporter and cognition in stroke : a case-control autopsy study / S. L. Kirvell, M. S. Elliott, R. N. Kalaria, T. Hortobágyi, C. G. Ballard, P. T. Francis
Dátum:2010
ISSN:0028-3878
Megjegyzések:OBJECTIVES: Vascular dementia (VaD) accounts for approximately 15%-20% of all dementias, but the relationship of progressive cognitive impairment to neurochemical changes is poorly understood. We have therefore investigated glutamatergic synaptic markers in VaD. METHODS: We used homogenates prepared from gray matter from 2 neocortical regions (Brodmann area [BA] 9 and BA 20) and Western blotting to determine the concentrations of key components of the glutamatergic neurotransmitter system, vesicular glutamate transporter 1 (VGLUT1) and excitatory amino acid transporter EAAT2 (GLT-1), and the ubiquitous synaptic protein, synaptophysin, in 73 individuals-48 patients with cerebrovascular disease with and without dementia, 10 patients with AD, and 15 controls-in a case-control design. RESULTS: VGLUT1 concentrations in BA 20 and BA 9 were correlated with CAMCOG total (Rs 0.525, p = 0.018, n = 20; Rs 0.560, p = 0.002, n = 27) and CAMCOG memory scores (Rs 0.616, p = 0.004, n = 20; Rs 0.675, p = 0.000, n = 27). VGLUT1 concentration in BA 9 differed between the different dementia groups and the stroke no dementia group (1-way analysis of variance F = 6.69, p = 0.001 and Bonferroni p < 0.01 in each case), with subjects with stroke who did not develop dementia exhibiting the highest mean value for VGLUT1. CONCLUSIONS: These data suggest that loss of glutamatergic synapses is a feature of VaD and Alzheimer disease but the preservation of synapses, in particular glutamatergic synapses, in the frontal cortex against the temporal cortex plays a role in sustaining cognition and protecting against dementia following a stroke.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 75 : 20 (2010), p. 1803-1809. -
További szerzők:Elliott, Mark S. J. Kalaria, Rajesh N. Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Francis, Paul T.
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12.

001-es BibID:BIBFORM020047
Első szerző:Mulugeta, Ezra
Cím:Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia / Ezra Mulugeta, Francisco Molina-Holgado, Mark S. Elliott, Tibor Hortobagyi, Robert Perry, Rajesh N. Kalaria, Clive G. Ballard, Paul T. Francis
Dátum:2008
ISSN:1420-8008
Megjegyzések:Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin (IL)-1beta, IL-1alpha, IL-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the status of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Dementia and Geriatric Cognitive Disorders. - 25 : 3 (2008), p. 278-286. -
További szerzők:Molina-Holgado, Francisco Elliott, Mark S. J. Hortobágyi Tibor (1965-) (patológus) Perry, Robert Kalaria, Rajesh N. Ballard, Clive G. Francis, Paul T.
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