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001-es BibID:BIBFORM063334
Első szerző:Alafuzoff, Irina
Cím:Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions : an inter-laboratory study by the BrainNet Europe consortium / Irina Alafuzoff, Maria Pikkarainen, Manuela Neumann, Thomas Arzberger, Safa Al-Sarraj, Istvan Bodi, Nenad Bogdanovic, Orso Bugiani, Isidro Ferrer, Ellen Gelpi, Stephen Gentleman, Giorgio Giaccone, Manuel B. Graeber, Tibor Hortobagyi, Paul G. Ince, James W. Ironside, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Tatjana Nilsson, Piero Parchi, Efstratios Patsouris, Tamas Revesz, Wolfgang Roggendorf, Annemieke Rozemuller, Danielle Seilhean, Nathalie Streichenberger, Dietmar R. Thal, Stephen B. Wharton, Hans Kretzschmar
Dátum:2015
ISSN:0300-9564
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neural Transmission. - 122 : 7 (2015), p. 957-972. -
További szerzők:Pikkarainen, Maria Neumann, Manuela Arzberger, Thomas Al-Sarraj, Safa Bódi István (1967-) (neuropatológus) Bogdanovic, Nenad Bugiani, Orso Ferrer, Isidro Gelpi, Ellen Gentleman, Stephen Giaccone, Giorgio Graeber, Manuel Hortobágyi Tibor (1965-) (patológus) Ince, Paul Ironside, James W. Kavantzas, Nikolaos King, Andrew Korkolopoulou, Penelope Kovács Gábor Géza (1969-) (neurológus) Meyronet, David Monoranu, Camelia Nilsson, Tatjana Parchi, Piero Patsouris, Efstratios Révész Tamás Roggendorf, Wolfgang Rozemuller, Annemieke Seilhean, Danielle Streichenberger, Nathalie Thal, Dietmar R. Wharton, Stephen B. Kretzschmar, Hans
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2.

001-es BibID:BIBFORM042976
Első szerző:Alafuzoff, Irina
Cím:The need to unify neuropathological assessments of vascular alterations in the ageing brain : multicentre survey by the BrainNet Europe consortium / Irina Alafuzoff, Ellen Gelpi, Safa Al-Sarraj, Thomas Arzberger, Johannes Attems, Istvan Bodi, Nenad Bogdanovic, Herbert Budka, Orso Bugiani, Elisabet Englund, Isidro Ferrer, Stephen Gentleman, Giorgio Giaccone, Manuel B. Graeber, Tibor Hortobagyi, Romana Höftberger, James W. Ironside, Kurt Jellinger, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Piero Parchi, Efstratios Patsouris, Wolfgang Roggendorf, Annemieke Rozemuller, Danielle Seilhean, Nathalie Streichenberger, Dietmar R. Thal, Stephen B. Wharton, Hans Kretzschmar
Dátum:2012
ISSN:0531-5565
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Gerontology. - 47 : 11 (2012), p. 825-833. -
További szerzők:Gelpi, Ellen Al-Sarraj, Safa Arzberger, Thomas Attems, Johannes Bódi István (1967-) (neuropatológus) Bogdanovic, Nenad Budka, Herbert Bugiani, Orso Englund, Elisabet Ferrer, Isidro Gentleman, Stephen Giaccone, Giorgio Graeber, Manuel Hortobágyi Tibor (1965-) (patológus) Höftberger, Romana Ironside, James W. Jellinger, Kurt Kavantzas, Nikolaos King, Andrew Korkolopoulou, Penelope Kovács Gábor Géza (1969-) (neurológus) Meyronet, David Monoranu, Camelia Parchi, Piero Patsouris, Efstratios Roggendorf, Wolfgang Rozemuller, Annemieke Seilhean, Danielle Streichenberger, Nathalie Thal, Dietmar R. Wharton, Stephen B. Kretzschmar, Hans
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3.

001-es BibID:BIBFORM020015
Első szerző:Alafuzoff, Irina
Cím:Assessment of beta-amyloid deposits in human brain : a study of the BrainNet Europe Consortium / Irina Alafuzoff, Dietmar R. Thal, Thomas Arzberger, Nenad Bogdanovic, Safa Al-Sarraj, Istvan Bodi, Susan Boluda, Orso Bugiani, Charles Duyckaerts, Ellen Gelpi, Stephen Gentleman, Giorgio Giaccone, Manuel Graeber, Tibor Hortobagyi, Romana Höftberger, Paul Ince, James W. Ironside, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Tatjana Nilsson, Piero Parchi, Efstratios Patsouris, Maria Pikkarainen, Tamas Revesz, Annemieke Rozemuller, Danielle Seilhean, Walter Schulz-Schaeffer, Nathalie Streichenberger, Stephen B. Wharton, Hans Kretzschmar
Dátum:2009
ISSN:0001-6322
Megjegyzések:Beta-Amyloid (A-beta) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently proposed in the same way as iota and alpha synuclein related lesions, also A-beta related pathology may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions. Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of A-beta, i.e. phase 1 = deposition of A-beta exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy (CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment of A-beta phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus, one may consider rating of A-beta-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer's disease (AD). Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Neuropathologica. - 117 : 3 (2009), p. 309-320. -
További szerzők:Thal, Dietmar R. Arzberger, Thomas Bogdanovic, Nenad Al-Sarraj, Safa Bódi István (1967-) (neuropatológus) Boluda, Susan Bugiani, Orso Duyckaerts, Charles Gelpi, Ellen Gentleman, Stephen Giaccone, Giorgio Graeber, Manuel Hortobágyi Tibor (1965-) (patológus) Höftberger, Romana Ince, Paul Ironside, James W. Kavantzas, Nikolaos King, Andrew Korkolopoulou, Penelope Kovács Gábor Géza (1969-) (neurológus) Meyronet, David Monoranu, Camelia Nilsson, Tatjana Parchi, Piero Patsouris, Efstratios Pikkarainen, Maria Révész Tamás Rozemuller, Annemieke Seilhean, Danielle Schulz-Schaeffer, Walter Streichenberger, Nathalie Wharton, Stephen B. Kretzschmar, Hans
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4.

001-es BibID:BIBFORM095313
035-os BibID:(cikkazonosító)e20202411 (WoS)000657498100002 (Scopus)85107071783
Első szerző:Heindl, Steffanie
Cím:Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies / Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T. Nelson, Ann M. Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz
Dátum:2021
ISSN:0022-1007 1540-9538
Megjegyzések:Neuroinflammation is an emerging focus of translational stroke research. Preclinical studies have demonstrated a critical role for brain-invading lymphocytes in post-stroke pathophysiology. Reducing cerebral lymphocyte invasion by anti-CD49d antibodies consistently improves outcome in the acute phase after experimental stroke models. However, clinical trials testing this approach failed to show efficacy in stroke patients for the chronic outcome 3 mo after stroke. Here, we identify a potential mechanistic reason for this phenomenon by detecting chronic T cell accumulation?evading the systemic therapy?in the post-ischemic brain. We observed a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke. Cerebral T cell accumulation in the post-ischemic brain was driven by increased local T cell proliferation rather than by T cell invasion. This observation urges re-evaluation of current immunotherapeutic approaches, which target circulating lymphocytes for promoting recovery after stroke.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Experimental Medicine. - 218 : 8 (2021), p. 1-14. -
További szerzők:Ricci, Alessio Carofiglio, Olga Zhou, Qihui Arzberger, Thomas Lénárt Nikolett Franzmeier, Nicolai Hortobágyi Tibor (1965-) (patológus) Nelson, Peter T. Stowe, Ann M. Dénes Ádám Edbauer, Dieter Liesz, Arthur
Pályázati támogatás:Nemzeti Agykutatási Program 2017-1.2.1-NKP-2017-00002
Egyéb
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5.

001-es BibID:BIBFORM051639
035-os BibID:PMID: 22471883
Első szerző:Kovács G. Gábor
Cím:Neuropathology of the hippocampus in FTLD-Tau with Pick bodies : a study of the BrainNet Europe Consortium / G. G. Kovacs, A. J. M. Rozemuller, J. C. van Swieten, E. Gelpi, K. Majtenyi, S. Al-Sarraj, C. Troakes, I. Bódi, A. King, T. Hortobágyi, M. M. Esiri, O. Ansorge, G. Giaccone, I. Ferrer, T. Arzberger, N. Bogdanovic, T. Nilsson, I. Leisser, I. Alafuzoff, J. W. Ironside, H. Kretzschmar, H. Budka
Dátum:2013
ISSN:0305-1846
Megjegyzések:Aims: Frontotemporal lobar degeneration with Pick bodies (Pick's disease) is characterized by the presence of tau immunoreactive spherical structures in the cytoplasm of neurons. In view of confusion about the molecular pathology of Pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration-associated protein depositions in the characteristically affected hippocampus. Methods: We evaluated immunoreactivity for tau (AT8, 3R, 4R), α-synuclein, TDP43, p62, and ubiquitin in the hippocampus, entorhinal and temporal cortex in 66 archival cases diagnosed neuropathologically as Pick's disease. Results: Mean age at death was 68.2 years (range 49 to 96). Fifty-two (79%) brains showed 3R immunoreactive spherical inclusions in the granule cells of the dentate gyrus. These typical cases presented mainly with the behavioural variant of FTD, followed by progressive aphasia, mixed syndromes or early memory disturbance. α-Synuclein immunoreactivity was seen only in occasional spherical tau-positive inclusions, TDP-43 IR was absent, and 4R IR was present only as neurofibrillary tangles in pyramidal neurons. Aβ immunoreactivity was observed in 16 cases; however, the overall level of Alzheimer's disease-related alterations was mainly low or intermediate (n = 3). Furthermore, we identified six cases with unclassifiable tauopathy. Conclusions: 1) Pick's disease may occur also in elderly patients and is characterized by a relatively uniform pathology with 3R tau inclusions particularly in the granule cells of dentate gyrus; 2) even minor deviation from these morphological criteria suggests a different disorder; and 3) immunohistological revision of archival cases expands the spectrum of tauopathies that require further classification. © 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society.
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Neuropathology and Applied Neurobiology. - 39 : 2 (2013), p. 166-178. -
További szerzők:Rozemuller, A. J. M. Swieten, John C. van Gelpi, Ellen Majtényi Katalin Al-Sarraj, Safa Troakes, Claire Bódi István (1967-) (neuropatológus) King, Andrew Hortobágyi Tibor (1965-) (patológus) Esiri, M. M. Ansorge, Olaf Giaccone, Giorgio Ferrer, Isidro Arzberger, Thomas Bogdanovic, Nenad Nilsson, Tatjana Leisser, I. Alafuzoff, Irina Ironside, James W. Kretzschmar, Hans Budka, Herbert
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6.

001-es BibID:BIBFORM063323
Első szerző:Kovács Gábor Géza (neurológus)
Cím:Aging-related tau astrogliopathy (ARTAG) : harmonized evaluation strategy / Gabor G. Kovacs, Isidro Ferrer, Lea T. Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J. Cairns, John F. Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M. Halliday, James W. Ironside, Seth Love, Ian R. Mackenzie, David G. Munoz, Melissa E. Murray, Peter T. Nelson, Hitoshi Takahashi, John Q. Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G. Beach, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Brittany N. Dugger, Mel Feany, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Kimmo J. Hatanpaa, Richard Heale, Patrick R. Hof, Monika Hofer, Tibor Hortobágyi, Kurt Jellinger, Gregory A. Jicha, Paul Ince, Julia Kofler, Enikö Kövari, Jillian J. Kril, David M. Mann, Radoslav Matej, Ann C. McKee, Catriona McLean, Ivan Milenkovic, Thomas J. Montine, Shigeo Murayama, Edward B. Lee, Jasmin Rahimi, Roberta D. Rodriguez, Annemieke Rozemüller, Julie A. Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B. Toledo, Markus Tolnay, Juan C. Troncoso, Harry V. Vinters, Serge Weis, Stephen B. Wharton, Charles L. White III, Thomas Wisniewski, John M. Woulfe, Masahito Yamada, Dennis W. Dickson
Dátum:2016
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta neuropathologica 131 : 1 (2016), p. 87-102. -
További szerzők:Ferrer, Isidro Grinberg, Lea T. Alafuzoff, Irina Attems, Johannes Budka, Herbert Cairns, Nigel J. Crary, John F. Duyckaerts, Charles Ghetti, Bernardino Halliday, Glenda Ironside, James W. Love, Seth Mackenzie, Ian R. Munoz, David G. Murray, Melissa E. Nelson, Peter T. Takahashi, Hitoshi Trojanowski, John Q. Ansorge, Olaf Arzberger, Thomas Baborie, Atik Beach, Thomas G. Bieniek, Kevin F. Bigio, Eileen H. Bódi István (1967-) (neuropatológus) Dugger, Brittany N. Feany, Mel Gelpi, Ellen Gentleman, Stephen Giaccone, Giorgio Hatanpaa, Kimmo J. Heale, Richard Hof, Patrick R. Hofer, Monika Hortobágyi Tibor (1965-) (patológus) Jellinger, Kurt Jicha, Gregory A. Ince, Paul Kofler, Julia Kővári Enikő Kril, Jillian J. Mann, David M. Matej, Radoslav McKee, Ann C. McLean, Catriona Milenkovic, Ivan Montine, Thomas J. Murayama, Shigeo Lee, Edward B. Rahimi, Jasmin Rodriguez, Roberta D. Rozemuller, Annemieke Schneider, Julie A. Schultz, Christian Seeley, William Seilhean, Danielle Smith, Colin Tagliavini, Fabrizio Takao, Masaki Thal, Dietmar R. Toledo, Jon B. Tolnay, Markus Troncoso, Juan C. Vinters, Harry V. Weis, Serge Wharton, Stephen B. White III, Charles L. Wisniewski, Thomas Woulfe, John M. Yamada, Masahito Dickson, Dennis W.
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