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1.
001-es BibID:
BIBFORM063334
Első szerző:
Alafuzoff, Irina
Cím:
Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions : an inter-laboratory study by the BrainNet Europe consortium / Irina Alafuzoff, Maria Pikkarainen, Manuela Neumann, Thomas Arzberger, Safa Al-Sarraj, Istvan Bodi, Nenad Bogdanovic, Orso Bugiani, Isidro Ferrer, Ellen Gelpi, Stephen Gentleman, Giorgio Giaccone, Manuel B. Graeber, Tibor Hortobagyi, Paul G. Ince, James W. Ironside, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Tatjana Nilsson, Piero Parchi, Efstratios Patsouris, Tamas Revesz, Wolfgang Roggendorf, Annemieke Rozemuller, Danielle Seilhean, Nathalie Streichenberger, Dietmar R. Thal, Stephen B. Wharton, Hans Kretzschmar
Dátum:
2015
ISSN:
0300-9564
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Journal Of Neural Transmission. - 122 : 7 (2015), p. 957-972. -
További szerzők:
Pikkarainen, Maria
Neumann, Manuela
Arzberger, Thomas
Al-Sarraj, Safa
Bódi István (1967-) (neuropatológus)
Bogdanovic, Nenad
Bugiani, Orso
Ferrer, Isidro
Gelpi, Ellen
Gentleman, Stephen
Giaccone, Giorgio
Graeber, Manuel
Hortobágyi Tibor (1965-) (patológus)
Ince, Paul
Ironside, James W.
Kavantzas, Nikolaos
King, Andrew
Korkolopoulou, Penelope
Kovács Gábor Géza (1969-) (neurológus)
Meyronet, David
Monoranu, Camelia
Nilsson, Tatjana
Parchi, Piero
Patsouris, Efstratios
Révész Tamás
Roggendorf, Wolfgang
Rozemuller, Annemieke
Seilhean, Danielle
Streichenberger, Nathalie
Thal, Dietmar R.
Wharton, Stephen B.
Kretzschmar, Hans
Internet cím:
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2.
001-es BibID:
BIBFORM042976
Első szerző:
Alafuzoff, Irina
Cím:
The need to unify neuropathological assessments of vascular alterations in the ageing brain : multicentre survey by the BrainNet Europe consortium / Irina Alafuzoff, Ellen Gelpi, Safa Al-Sarraj, Thomas Arzberger, Johannes Attems, Istvan Bodi, Nenad Bogdanovic, Herbert Budka, Orso Bugiani, Elisabet Englund, Isidro Ferrer, Stephen Gentleman, Giorgio Giaccone, Manuel B. Graeber, Tibor Hortobagyi, Romana Höftberger, James W. Ironside, Kurt Jellinger, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Piero Parchi, Efstratios Patsouris, Wolfgang Roggendorf, Annemieke Rozemuller, Danielle Seilhean, Nathalie Streichenberger, Dietmar R. Thal, Stephen B. Wharton, Hans Kretzschmar
Dátum:
2012
ISSN:
0531-5565
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:
Experimental Gerontology. - 47 : 11 (2012), p. 825-833. -
További szerzők:
Gelpi, Ellen
Al-Sarraj, Safa
Arzberger, Thomas
Attems, Johannes
Bódi István (1967-) (neuropatológus)
Bogdanovic, Nenad
Budka, Herbert
Bugiani, Orso
Englund, Elisabet
Ferrer, Isidro
Gentleman, Stephen
Giaccone, Giorgio
Graeber, Manuel
Hortobágyi Tibor (1965-) (patológus)
Höftberger, Romana
Ironside, James W.
Jellinger, Kurt
Kavantzas, Nikolaos
King, Andrew
Korkolopoulou, Penelope
Kovács Gábor Géza (1969-) (neurológus)
Meyronet, David
Monoranu, Camelia
Parchi, Piero
Patsouris, Efstratios
Roggendorf, Wolfgang
Rozemuller, Annemieke
Seilhean, Danielle
Streichenberger, Nathalie
Thal, Dietmar R.
Wharton, Stephen B.
Kretzschmar, Hans
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM020015
Első szerző:
Alafuzoff, Irina
Cím:
Assessment of beta-amyloid deposits in human brain : a study of the BrainNet Europe Consortium / Irina Alafuzoff, Dietmar R. Thal, Thomas Arzberger, Nenad Bogdanovic, Safa Al-Sarraj, Istvan Bodi, Susan Boluda, Orso Bugiani, Charles Duyckaerts, Ellen Gelpi, Stephen Gentleman, Giorgio Giaccone, Manuel Graeber, Tibor Hortobagyi, Romana Höftberger, Paul Ince, James W. Ironside, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Tatjana Nilsson, Piero Parchi, Efstratios Patsouris, Maria Pikkarainen, Tamas Revesz, Annemieke Rozemuller, Danielle Seilhean, Walter Schulz-Schaeffer, Nathalie Streichenberger, Stephen B. Wharton, Hans Kretzschmar
Dátum:
2009
ISSN:
0001-6322
Megjegyzések:
Beta-Amyloid (A-beta) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently proposed in the same way as iota and alpha synuclein related lesions, also A-beta related pathology may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions. Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of A-beta, i.e. phase 1 = deposition of A-beta exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy (CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment of A-beta phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus, one may consider rating of A-beta-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer's disease (AD). Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Acta Neuropathologica. - 117 : 3 (2009), p. 309-320. -
További szerzők:
Thal, Dietmar R.
Arzberger, Thomas
Bogdanovic, Nenad
Al-Sarraj, Safa
Bódi István (1967-) (neuropatológus)
Boluda, Susan
Bugiani, Orso
Duyckaerts, Charles
Gelpi, Ellen
Gentleman, Stephen
Giaccone, Giorgio
Graeber, Manuel
Hortobágyi Tibor (1965-) (patológus)
Höftberger, Romana
Ince, Paul
Ironside, James W.
Kavantzas, Nikolaos
King, Andrew
Korkolopoulou, Penelope
Kovács Gábor Géza (1969-) (neurológus)
Meyronet, David
Monoranu, Camelia
Nilsson, Tatjana
Parchi, Piero
Patsouris, Efstratios
Pikkarainen, Maria
Révész Tamás
Rozemuller, Annemieke
Seilhean, Danielle
Schulz-Schaeffer, Walter
Streichenberger, Nathalie
Wharton, Stephen B.
Kretzschmar, Hans
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM051639
035-os BibID:
PMID: 22471883
Első szerző:
Kovács G. Gábor
Cím:
Neuropathology of the hippocampus in FTLD-Tau with Pick bodies : a study of the BrainNet Europe Consortium / G. G. Kovacs, A. J. M. Rozemuller, J. C. van Swieten, E. Gelpi, K. Majtenyi, S. Al-Sarraj, C. Troakes, I. Bódi, A. King, T. Hortobágyi, M. M. Esiri, O. Ansorge, G. Giaccone, I. Ferrer, T. Arzberger, N. Bogdanovic, T. Nilsson, I. Leisser, I. Alafuzoff, J. W. Ironside, H. Kretzschmar, H. Budka
Dátum:
2013
ISSN:
0305-1846
Megjegyzések:
Aims: Frontotemporal lobar degeneration with Pick bodies (Pick's disease) is characterized by the presence of tau immunoreactive spherical structures in the cytoplasm of neurons. In view of confusion about the molecular pathology of Pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration-associated protein depositions in the characteristically affected hippocampus. Methods: We evaluated immunoreactivity for tau (AT8, 3R, 4R), α-synuclein, TDP43, p62, and ubiquitin in the hippocampus, entorhinal and temporal cortex in 66 archival cases diagnosed neuropathologically as Pick's disease. Results: Mean age at death was 68.2 years (range 49 to 96). Fifty-two (79%) brains showed 3R immunoreactive spherical inclusions in the granule cells of the dentate gyrus. These typical cases presented mainly with the behavioural variant of FTD, followed by progressive aphasia, mixed syndromes or early memory disturbance. α-Synuclein immunoreactivity was seen only in occasional spherical tau-positive inclusions, TDP-43 IR was absent, and 4R IR was present only as neurofibrillary tangles in pyramidal neurons. Aβ immunoreactivity was observed in 16 cases; however, the overall level of Alzheimer's disease-related alterations was mainly low or intermediate (n = 3). Furthermore, we identified six cases with unclassifiable tauopathy. Conclusions: 1) Pick's disease may occur also in elderly patients and is characterized by a relatively uniform pathology with 3R tau inclusions particularly in the granule cells of dentate gyrus; 2) even minor deviation from these morphological criteria suggests a different disorder; and 3) immunohistological revision of archival cases expands the spectrum of tauopathies that require further classification. © 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:
Neuropathology and Applied Neurobiology. - 39 : 2 (2013), p. 166-178. -
További szerzők:
Rozemuller, A. J. M.
Swieten, John C. van
Gelpi, Ellen
Majtényi Katalin
Al-Sarraj, Safa
Troakes, Claire
Bódi István (1967-) (neuropatológus)
King, Andrew
Hortobágyi Tibor (1965-) (patológus)
Esiri, M. M.
Ansorge, Olaf
Giaccone, Giorgio
Ferrer, Isidro
Arzberger, Thomas
Bogdanovic, Nenad
Nilsson, Tatjana
Leisser, I.
Alafuzoff, Irina
Ironside, James W.
Kretzschmar, Hans
Budka, Herbert
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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