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001-es BibID:	BIBFORM020059
Első szerző:	Hortobágyi Tibor (patológus)
Cím:	Traumatic axonal damage in the brain can be detected using β-APP immunohistochemistry within 35 min after head injury to human adults / T. Hortobágyi, S. Wise, N. Hunt, N. Cary, V. Djurovic, A. Fegan-Earl, K. Shorrock, D. Rouse, S. Al-Sarraj
Dátum:	2007
ISSN:	0305-1846
Megjegyzések:	Immunohistochemistry staining for beta-amyloid precursor protein (beta-APP) is a sensitive method to detect early axonal damage in traumatic brain injury, which was previously estimated to be of minimum 60-90 min after head injury. We present seven cases of well-documented posttraumatic survival of 35-60 min where beta-APP detects early axonal damage. Cases were selected from routine work where documentation about survival is judged to be accurate. These are divided into three groups: group 1: severe head injury (n = 7) with documented survival between 35 and 60 min. Group 2: severe head injury (n = 4) with documented survival of less than 30 min. Group 3: cases (n = 4) where death was not due to head injury but survival is documented between 45 and 109 min. The brains were fixed in formalin for 4 weeks and six regions (frontal lobe with anterior corpus callosum, parietal lobe with deep white matter, basal ganglia with posterior limb of internal capsule, cerebellum with white matter and middle cerebellar peduncle and pons with basis pontis and superior cerebellar peduncle) were sampled. All blocks were stained for haematoxylin and eosin and beta-APP and selected ones for CD68, using antigen retrieval method. In group 1 sections revealed beta-APP immunoreactivity in forms of small globules and granules and occasionally as thin and short filaments. These were detected in the pons, corpus callosum, internal capsule and cerebral white matter, with some variation in localization and intensity. In groups 2 and 3 all the sections were negative for beta-APP staining. None of the cases showed evidence of severe brain swelling, increased intracranial pressure, ischaemia or infection. Using the antigen retrieval method, beta-APP immunohistochemistry can detect axonal damage within 35 min after severe head injury. These results may have an implication in the consideration of minimal survival time after traumatic head injury in medico-legal practice.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuropathology and Applied Neurobiology. - 33 : 2 (2007), p. 226-237. -
További szerzők:	Wise, S. Hunt, N. Cary, N. Djurovic, Vesna Fegan-Earl, A. Shorrock, K. Rouse, D. Al-Sarraj, Safa
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001-es BibID:	BIBFORM020019
Első szerző:	Hortobágyi Tibor (patológus)
Cím:	Cysticercosis of the fourth ventricle causing sudden death : a case report and review of the literature / Tibor Hortobágyi, Ali Alhakim, Olaf Biedrzycki, Vesna Djurovic, Jeewan Rawal, Safa Al-Sarraj
Dátum:	2008
ISSN:	1219-4956
Megjegyzések:	A 15 years old girl of African origin was admitted with a history of headaches and a generalised tonic seizure. Her clinical examination including fundoscopy was normal. She claimed she had been assaulted. Within a few hours of her admission she was found dead in her bed during the ward round. Cardiopulmonary resuscitation was unsuccessful. At post-mortem, the major organs showed no pathological changes and neck dissection showed no abnormality. Neuropathological examination after formalin fixation revealed a cystic lesion in the fourth ventricle, ependymitis and acute hydrocephalus. Histology showed parts of the parasite Taenia solium and the diagnosis was neurocysticercosis. This case highlights the need for forensic and general pathologists as well as forensic medical examiners and paediatricians to be aware of neurocysticercosis as a possible cause of sudden death in the presence of normal clinical findings and negative autopsy, especially in patients from Asian, African or South American countries. As cysticercosis is the commonest cause of seizures in the developing world, neurocysticercosis needs to be considered as a cause of sudden and unexpected death in any patient with a history of headaches and/or seizures.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pathology and Oncology Research. - 15 : 1 (2008), p. 143-146. -
További szerzők:	Alhakim, Ali Biedrzycki, Olaf Djurovic, Vesna Rawal, Jeewan Al-Sarraj, Safa
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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