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001-es BibID:BIBFORM020297
Első szerző:Eskesen, Karen
Cím:Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction = Humán artériák kalcitoninszerű receptor és receptoraktivitást módosító fehérjék mRNS-expressziójának változásai stroke-ban és akut szívinfarktusban / Karen Eskesen, Tajti János, Hortobágyi Tibor, Szok Délia, Vécsei László, Lars Edvinsson
Dátum:2007
ISSN:0019-1442
Megjegyzések:Calcitonin-like receptor (CL-R) is a functional CGRP1-receptor when complexed with RAMP1 or an adrenomedullin-receptor or when complexed with RAMP2 or RAMP3. This study was carried out 1. to set up a method to examine the relative quantity of mRNA of CL-R, RAMP1, RAMP2 and RAMP3 in human coronary (CA), pulmonary (PA) and middle cerebral arteries (MCA), and 2. to examine the level of mRNA expression in cerebra- and cardiovascular diseases. The method was validated with respect to the use of postmortem tissue and we compared beta-actin and GAPDH as housekeeping genes. There was no time-dependent change in total RNA and level of mRNA for p-actin or GAPDH could be detected in vessels removed from 1 and 5 days post mortem. The expression of beta-actin appears lower in coronary artery than in pulmonary artery and middle cerebral artery with no significant difference for GAPDH; both worked well. There were some differences in mRNA expression for CL-R (higher) and RAMP3 (lower) in middle cerebral artery compared to coronary artery and pulmonary artery. There was no significant difference in mRNA for RAMP1 and RAMP2 in the three types of arteries. We did not observe any difference in mRNA for CL-R and RAMPs in arteries from patients with hemorrhagic stroke, arteriosclerosis and acute myocardial infarction when compared to patients without these diagnoses. Thus the mRNA expression seems to be unaltered in these disorders.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Ideggyógyászati Szemle. - 60 : 11-12 (2007), p. 459-466. -
További szerzők:Tajti János Hortobágyi Tibor (1965-) (patológus) Szok Délia Vécsei László (1954-) (neurológus) Edvinsson, Lars
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001-es BibID:BIBFORM020068
Első szerző:Wackenfors, Angelica
Cím:Ischemic heart disease induce upregulation of endothelin receptor mRNA in human coronary arteries / Angelica Wackenfors, Malin Emilson, Richard Ingemansson, Tibor Hortobagyi, Delia Szok, Janos Tajti, Laszlo Vecsei, Lars Edvinsson, Malin Malmsjö
Dátum:2004
ISSN:0014-2999
Megjegyzések:Endothelin has been implicated in the pathogenesis of ischemic heart disease and congestive heart failure. The aims were to quantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in human coronary arteries from patients with ischemic heart disease, congestive heart failure and controls using real-time polymerase chain reaction (real-time PCR). In addition, the suitability of organ culture as a model mimicking endothelin receptor changes in cardiovascular disease was evaluated by in vitro pharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels were significantly higher in arteries from patients with ischemic heart disease (0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure (0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). After organ culture, the endothelin ETB receptor mRNA levels were elevated, and the sarafotoxin 6c-induced vasoconstriction was more efficacious. Increased endothelin receptor activity may contribute to the increased vascular tone and development of atherosclerotic disease in ischemic heart disease in man.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Pharmacology. - 484 : 1 (2004), p. 103-109. -
További szerzők:Emilson, Malin Ingemansson, Richard Hortobágyi Tibor (1965-) (patológus) Szok Délia Tajti János Vécsei László (1954-) (neurológus) Edvinsson, Lars Malmsjö, Malin
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