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1.

001-es BibID:BIBFORM069190
Első szerző:Alghamdi, Amani
Cím:Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia / Alghamdi Amani, Vallortigara Julie, Howlett David R., Broadstock Martin, Hortobágyi Tibor, Ballard Clive, Thomas Alan J., O'Brien John T., Aarsland Dag, Attems Johannes, Francis Paul T., Whitfield David R.
Dátum:2017
ISSN:1387-2877
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Alzheimers Disease 57 : 2 (2017), p. 373-386. -
További szerzők:Vallortigara, Julie Howlett, David R. Broadstock, Martin Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Attems, Johannes Francis, Paul T. Whitfield, David
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2.

001-es BibID:BIBFORM063676
Első szerző:Howlett, David R.
Cím:Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias / David R. Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T. O'Brien, Dag Aarsland, Mitchell K.P. Lai, Jasinda H. Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T. Francis
Dátum:2015
ISSN:1015-6305
Megjegyzések:Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterizedby the presence of ?-synuclein-containing Lewy bodies and Lewy neurites.However, both dementias also show variable degrees of Alzheimer's disease (AD) pathology(senile plaques and neurofibrillary tangles), particularly in areas of the cortex associatedwith higher cognitive functions. This study investigates the contribution of theindividual and combined pathologies in determining the rate of cognitive decline. Cortical?-synuclein, phosphorylated tau (phosphotau) and A? plaque pathology in 34 PDD and 55DLB patients was assessed semi-quantitatively in four regions of the neocortex. The declinein cognition, assessed by Mini Mental State Examination, correlated positively with thecortical ?-synuclein load. Patients also had varying degrees of senile A? plaque andphosphotau pathology. Regression analyses pointed to a combined pathology (A? plaqueplus phosphotau plus ?-synuclein-positive features), particularly in the prefrontal cortex(BA9) and temporal lobe neocortex with the superior and middle temporal gyrus (BA21,22), being a major determining factor in the development of dementia. Thus, cognitivedecline in Lewy body dementias is not a consequence of ?-synuclein-induced neurodegenerationalone but senile plaque and phosphorylated tau pathology also contribute tothe overall deficits.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Pathology. - 25 : 4 (2015), p. 401-408. -
További szerzők:Whitfield, David Johnson, Mary Attems, Johannes O'Brien, John Aarsland, Dag Lai, Mitchell K.P. Lee, Jasinda H. Chen, Christopher Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
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3.

001-es BibID:BIBFORM063678
Első szerző:Vallortigara, Julie
Cím:Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia / Julie Vallortigara, David Robert Edward Whitfield, William Quelch, Amani Alghamdi, David R. Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, John T. O'Brien, Alan J. Thomas, Clive G. Ballard, Dag Aarsland, Paul T. Francis
Dátum:2015
ISSN:1387-2877
Megjegyzések:Alpha-synuclein (?-syn) aggregations are the key pathological hallmark of dementia withLewy bodies (DLB) and Parkinson's disease dementia (PDD), but are also frequently presentin Alzheimer's disease (AD). Yet much remains unknown about the role of ?-syn in thesynapse and the wider role of synaptic dysfunction in these dementias. Changes inconcentrations of key ♭SNAP (Soluble N-ethylmaleimide Sensitive Factor AttachmentProtein) Receptor' (SNARE) proteins as a consequence of alterations in the aggregation stateof ?-syn may contribute to synaptic dysfunction in patients with DLB, PDD and AD and resultin impaired cognition. We have studied a large cohort (n=130) of autopsy confirmed DLB,PDD, AD and control brains. Using semi-quantitative western blotting we havedemonstrated significant changes across the diagnostic groups of DLB, PDD and AD in theSNARE and vesicle proteins syntaxin, Munc18, VAMP2 and monomeric ?-syn in theprefrontal cortex, with a significant reduction of Munc18 in AD patients (p<0.001). Thiscorrelated to the final MMSE score before death (p=0.016). We also identified a significantnegative correlation between the duration of dementia and the levels of the bindingpartners VAMP2 (p=0.0004) and monomeric ?-syn (p=0.0002). It is of particular note that thisassociation was identified in people with AD. Our findings may indicate that an upregulationof SNARE complex related proteins occurs in the early stages of disease as an attempt atcompensating for failing synapses, prior to widespread deposition of pathological ?-syn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Dementia with Lewy bodies
Parkinson's disease dementia
Alzheimer's disease
Synaptic dysfunction
SNARE process
Alpha-synuclein
VAMP2
Munc18
Megjelenés:Journal Of Alzheimers Disease. - 50 : 1 (2015), p. 101-110. -
További szerzők:Whitfield, David Quelch, William Alghamdi, Amani Howlett, David R. Hortobágyi Tibor (1965-) (patológus) Johnson, Mary Attems, Johannes O'Brien, John Thomas, Alan Ballard, Clive G. Aarsland, Dag Francis, Paul T.
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4.

001-es BibID:BIBFORM062827
Első szerző:Vallortigara, Julie
Cím:Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia / Julie Vallortigara, Sindhoo Rangarajan, David Whitfield, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Clive Ballard, Alan Thomas, John O'Brien, Dag Aarsland, Paul Francis
Dátum:2014
ISSN:2046-1402
Megjegyzések:Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD) together, represent the second most common cause of dementia, after Alzheimer's disease (AD). The synaptic dysfunctions underlying the cognitive decline and psychiatric symptoms observed throughout the development of PDD and DLB are still under investigation. In this study we examined the expression level of Dynamin1 and phospho-CaMKII, key proteins of endocytosis and synaptic plasticity respectively, as potential markers of molecular processes specifically deregulated with DLB and/or PDD. In order to measure the levels of these proteins, we isolated grey matter from post-mortem prefrontal cortex area (BA9), anterior cingulated gyrus (BA24) and parietal cortex (BA40) from DLB and PDD patients in comparison to age-matched controls and a group of AD cases. Clinical and pathological data available included the MMSE score, neuropsychiatric history, and semi-quantitative scores for AD pathology (plaques - tangles) and for ?-synuclein (Lewy bodies). Changes in the expression of the synaptic markers, and correlates with neuropathological features and cognitive decline were predominantly found in the prefrontal cortex. On one hand, levels of Dynamin1 were significantly reduced, and correlated with a higher rate of cognitive decline observed in cases from three dementia groups. On the other hand, the fraction of phospho-CaMKII was decreased, and correlated with a high score of plaques and tangles in BA9. Interestingly, the correlation between the rate of cognitive decline and the level of Dynamin1 remained when the analysis was restricted to the PDD and DLB cases, highlighting an association of Dynamin1 with cognitive decline in people with Lewy Body dementia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:F1000Research. - 3 : 108 (2014), p. 1-11. -
További szerzők:Rangarajan, Sindhoo Whitfield, David Alghamdi, Amani Howlett, David R. Hortobágyi Tibor (1965-) (patológus) Johnson, Mary Attems, Johannes Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Francis, Paul T.
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5.

001-es BibID:BIBFORM063680
Első szerző:Whitfield, David
Cím:Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia / David R. Whitfield, Julie Vallortigara, Amani Alghamdi, Tibor Hortobágyi, Clive Ballard, Alan J. Thomas, John T. O'Brien, Dag Aarsland, Paul T. Francis
Dátum:2015
ISSN:1064-7481
Megjegyzések:OBJECTIVE:Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in depression and synaptic dysfunction. We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study.METHODS:We examined brains from people with PDD (N = 29), DLB (N = 27), and AD (N = 15) and comparison subjects without depression or dementia (N = 24). Individuals were categorized according to the presence and severity of depression (on a scale of 0-3) based on standardized assessments during life (principally Neuropsychiatric Inventory). Western blotting was used to determine ZnT3 levels in Brodmann area 9 (BA9), and regression analysis was used to determine the relationship between ZnT3 and depression.RESULTS:Reductions in ZnT3 in BA9 were significantly associated with elevated depression scores in the study cohort (? = -0.351, df = 93, t = -3.318 p = 0.0004). This association remained when only individuals with DLB, PDD, and no dementia or depression were examined (? = -0.347, df = 78, t = -3.271, p = 0.002) or only individuals with AD and no dementia or depression were examined (? = -0.433, df = 37, t = -2.924, p = 0.006).CONCLUSION:Although decreased zinc levels have been implicated in the genesis of depression in animal models and in major depressive disorder in humans, this study provides the first evidence of a role for zinc in depression in people with dementia and highlights zinc metabolism as a therapeutic target.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Depression
Alzheimer disease
Lewy body dementia
Parkinson disease dementia
zinc
Megjelenés:American Journal Of Geriatric Psychiatry. - 23 : 2 (2015), p. 141-148. -
További szerzők:Vallortigara, Julie Alghamdi, Amani Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Francis, Paul T.
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6.

001-es BibID:BIBFORM063341
Első szerző:Whitfield, David
Cím:Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease : association with cognitive impairment / David R. Whitfield, Julie Vallortigara, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Stephen Newhouse, Clive Ballard, Alan J. Thomas, John T. O'Brien, Dag Aarsland, Paul T. Francis
Dátum:2014
ISSN:0197-4580
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurobiology Of Aging. - 35 : 12 (2014), p. 2836-2844. -
További szerzők:Vallortigara, Julie Alghamdi, Amani Howlett, David R. Hortobágyi Tibor (1965-) (patológus) Johnson, Mary Attems, Johannes Newhouse, Stephen Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Francis, Paul T.
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