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001-es BibID:BIBFORM082386
035-os BibID:(WoS)000528101100002 (Scopus)85084051209
Első szerző:Ashton, Nicholas J.
Cím:An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders / Nicholas J. Ashton, Abdul Hye, Anto P. Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas K. Karikari, Michael Schöll, Renaud La Joie, Gil D. Rabinovici, Kina Höglund, Clive Ballard1, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Dátum:2020
ISSN:1471-003X 1471-0048
Megjegyzések:In recent years, there has been an increasing emphasis on the importance of blood-based biomarkers in the first-in-line evaluation of patients with suspected neurodegenerative disorders (NDD). While neuroimaging (structural and molecular) and cerebrospinal fluid (CSF) analyses identify the underlying pathophysiology at the earliest stage, a biologically relevant marker derived from blood would have greater utility in the primary care setting and in the early screening for eligibility for therapeutic trials. The rapid advancement of ultra-sensitive assays has enabled the investigation of pathological proteins to be measured in blood samples, but research has been predominately focused on Alzheimer's disease (AD) cohorts. Nonetheless, proteins that are currently under scrutiny as blood biomarker candidates for AD (amyloid-?, tau and neurofilament light chain) are likely to have importance for Lewy body dementia's (LBD), frontotemporal dementia's (FTD) and other NDDs in terms of shared pathologies, similar degenerative processes or in the differential diagnosis of clinical symptoms. This review gives an overview and update on the current state of blood-based biomarkers for non-AD NDD, focusing on how candidate AD and novel biomarkers perform in these populations. As background information, we also briefly outline the neuropathological, clinical, molecular imaging and CSF features of the most common NDDs outside of the AD continuum.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nature Reviews Neuroscience. - 16 : 5 (2020), p. 265-284. -
További szerzők:Hye, Abdul Rajkumar, Anto P. Leuzy, Antoine Snowden, Stuart Suárez-Calvet, Marc Karikari, Thomas K. Schöll, Michael La Joie, Renaud Rabinovici, Gil D. Höglund, Kina Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Svenningsson, Per Blennow, Kaj Zetterberg, Henrik Aarsland, Dag
Pályázati támogatás:(2017-1.2.1-NKP-2017-00002)
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2.

001-es BibID:BIBFORM082378
035-os BibID:(cikkazonosító)5 (WoS)000455320300001 (Scopus)85059798236
Első szerző:Ashton, Nicholas J.
Cím:Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration / Nicholas J. Ashton, Antoine Leuzy, Yau Mun Lim, Claire Troakes, Tibor Hortobágyi, Kina Höglund, Dag Aarsland, Simon Lovestone, Michael Schöll, Kaj Blennow, Henrik Zetterberg, Abdul Hye
Dátum:2019
ISSN:2051-5960
Megjegyzések:Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid- (A) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic prospect to highlight accumulating pathology for secondary prevention trials. Neurofilament light chain (NfL), a marker of axonal degeneration, is robustly elevated in the blood of many neurological and neurodegenerative conditions, including AD. A strong relationship with cerebrospinal fluid (CSF) NfL suggests that these biomarker modalities reflect the same pathological process. Yet, the connection between blood NfL and brain tissue pathology has not been directly compared. In this study, longitudinal plasma NfL from cognitively healthy controls (n=12) and AD participants (n=57) were quantified by the Simoa platform. On reaching post-mortem, neuropathological assessment was performed on all participants, with additional frozen and paraffin-embedded tissue acquired from 26 participants for further biochemical (A(1-42), A(1-40), tau) and histological (NfL) evaluation. Plasma NfL concentrations were significantly increased in AD and correlated with cognitive decline, independent of age. Retrospective stratification based on Braak staging revealed that baseline plasma NfL concentrations were associated with higher neurofibrillary tangle pathology at post-mortem. Longitudinal increases in plasma NfL were observed in all Braak groupings; a significant negative association, however, was found between plasma NfL at time point 1 and both its rate of change and annual percentage increase. Immunohistochemical evaluation of NfL in the medial temporal gyrus (MTG) demonstrated an inverse relationship between Braak stages and NfL staining. Importantly, a significant negative correlation was found between the plasma NfL measurement closest to death and the level of NfL staining in the MTG at post-mortem. For the first time, we demonstrate that plasma NfL associates with the severity of neurofibrillary tangle pathology and neurodegeneration in the post-mortem brain.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Acta Neuropathologica Communications. - 7 : 1 (2019), p. 1-11. -
További szerzők:Leuzy, Antoine Lim, Yau Mun Troakes, Claire Hortobágyi Tibor (1965-) (patológus) Höglund, Kina Aarsland, Dag Lovestone, Simon Schöll, Michael Blennow, Kaj Zetterberg, Henrik Hye, Abdul
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DOI
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3.

001-es BibID:BIBFORM083679
Első szerző:Bencze János (orvos)
Cím:Dementia with Lewy bodies - a clinicopathological update / János Bencze, Woosung Seo, Abdul Hye, Dag Aarsland, Tibor Hortobágyi
Dátum:2020
Megjegyzések:Dementia is one of the major burdens of our aging society. According to certain predictions, the number of patients will double every 20 years. Although Alzheimer's disease (AD), as the most frequent neurodegenera-tive dementia, has been extensively analysed, less is known about dementia with Lewy bodies (DLB). Neuropa-thological hallmarks of DLB are the deposition of intracellular Lewy bodies (LB) and Lewy neurites (LN). DLB belongs to the ?-synucleinopathies, as the major component of these inclusions is pathologically aggregated ?-synuclein. Depending on the localizationof LBs and LNs in the central nervous system cognitive and motor symptoms can occur. In our work, we will systematically review the possible etiology and epidemiology, patho-logical (both macroscopic and microscopic) features, structural and functional imaging findings, with a special emphasis on the clinico-pathological correlations. Finally, we summarize the latest clinical symptoms-based diagnostic criteria and the novel therapeutic approaches. Since DLB is frequently accompanied with AD pathol-ogy, highlighting possible differential diagnostic approaches is an integral part of our paper. Although our pre-sent knowledge is insufficient, the rapid development of diagnostic and research methodsprovide hope for better diagnosis and more efficient treatment, contributing to a better quality of life.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Free Neuropathology. - 1 (2020), p. 1-12. -
További szerzők:Seo, Woosung Hye, Abdul Aarsland, Dag Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
GINOP-2.3.2-15-2016-00043
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NAP (2017-1.2.1-NKP-2017-00002)
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ÚNKP-19-3
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NKFIH SNN 132999
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DOI
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