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001-es BibID:BIBFORM082380
035-os BibID:(WoS)000461051200020 (Scopus)85062851009
Első szerző:Giil, Lasse Melvaer
Cím:Serum Potassium Is Associated with Cognitive Decline in Patients with Lewy Body Dementia / Lasse Melvaer Giil, Stein-Erik Hafstad Solvang, Malin Melvaer Giil, Kristoffer H. Hellton, Ragnhild Eide Skogseth, Audun Osland Vik-Mo, Tibor Hortobágyi, Dag Aarsland, Jan Erik Nordrehaug
Dátum:2019
ISSN:1387-2877
Megjegyzések:Background:Epidemiological studies link serum potassium (K+) to cognitive performance, but whether cognitive prognosis in dementia is related to K+ levels is unknown. Objective:To determine if K+ levels predict cognitive prognosis in dementia and if this varies according to diagnosis or neuropathological findings. Methods:This longitudinal cohort study recruited 183 patients with mild Alzheimer's disease or Lewy body dementia (LBD). Serum K+ and eGFR were measured at baseline and medications which could affect K+ registered. The Mini-Mental State Examination (MMSE) was measured annually over 5 years, and mortality registered. Association between K+ and ?(30 -MMSE) was estimated overall, and according to diagnosis (joint model). Associations between MMSE-decline and K+ were assessed in two subgroups with neuropathological examination (linear regression) or repeated measurements of K+ over 3 years (mixed model). Results:Serum K+ at baseline was associated with more errors on MMSE over time (Estimate 0.18, p?=?0.003), more so in LBD (p?=?0.048). The overall association and LBD interaction were only significant in the 122 patients not using K+ relevant medication. Repeated K+ measures indicated that the association with MMSE errors over time was due to a between-person effect (p?<?0.05, n?=?57). The association between the annual MMSE decline was stronger in patients with autopsy confirmed LBD and more α-synuclein pathology (all: p?<?0.05, n?=?41). Conclusion:Higher serum K+ predicts poorer cognitive prognosis in demented patients not using medications which affect K+, likely a between-person effect seen mainly in LBD.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:Journal of Alzheimers Disease. - 68 : 1 (2019), p. 239-253. -
További szerzők:Solvang, Stein-Erik Hafstad Giil, Malin Melvaer Hellton, Kristoffer H. Skogseth, Ragnhild Eide Vik-Mo, Audun Osland Hortobágyi Tibor (1965-) (patológus) Aarsland, Dag Nordrehaug, Jan Erik
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