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001-es BibID:	BIBFORM069720
Első szerző:	Harangi Mariann (belgyógyász, endokrinológus)
Cím:	LDL apheresis or PCSK9 inhibition? Sometimes we have to combine them / Mariann Harangi, Lilla Juhász, Bíborka Nádró, József Balla, György Paragh
Dátum:	2017
Megjegyzések:	This study presents the case of a female patient with severe heterozygous familialhypercholesterolemia. Despite the combined maximum dose oral treatment with rosuvastatinand ezetimibe, we found markedly elevated lipid parameters. Therefore, we indicated monthlyselective low density lipoprotein (LDL) apheresis treatment using the Direct Adsorption ofLipoproteins system. After more than 2 years the lipid levels of the patients were still above thetherapeutic goals. Finally, we completed the treatment by the inhibitor evolocumab biweekly.Further LDL cholesterol (LDL-C) reduction was achieved resulting in lipid parameters ongoals. However, administration of evolocumab without LDL apheresis could not reduce theLDL-C below 2.5 mmol/L. We concluded that both LDL apheresis and proprotein convertasesubtilisin/kexin type 9 (PCSK9) inhibitor treatments were effective and well tolerated. None ofthem alone would be enough to achieve lipid goals in this patient. However, the combination ofthese potent treatments may normalize the lipid levels and prevent cardiovascular complications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban LDL apheresis PCSK9 inhibition familial hypercholesterolemia low-density lipoprotein lipoprotein(a)
Megjelenés:	Vessel Plus. - 1 (2017), p. 91-95. -
További szerzők:	Juhász Lilla (1990-) (általános orvos) Nádró Bíborka (1992-) (általános orvos) Balla József (1959-) (belgyógyász, nephrológus) Paragh György (1953-) (belgyógyász)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM077799
Első szerző:	Zsíros Noémi (belgyógyász)
Cím:	Successful plasmapheresis treatment of severe hypertriglyceridemia during late pregnancy / Noémi Zsíros, Beáta Kovács, György Paragh, József Balla, Mariann Harangi
Dátum:	2019
Megjegyzések:	During pregnancy, physiologic hormonal changes provoke a significant increase in triglyceride levels. Genetic abnormalities of triglyceride metabolism and secondary factors may multiply the risk of severe lipid abnormalities. Although severe gestational hypertriglyceridemia can be a life-threatening condition for both mother and fetus, its optimal treatment has not been fully clarified. A 33-year-old woman at 37 weeks of her second pregnancy was admitted to our clinic. Her triglyceride level was 57.8 mmol/L. Abdominal pain, nausea, vomiting or any other complaints were not reported. She kept a fat-restricted diet, however her triglyceride level remained 41 mmol/L. Therefore we decided to perform plasmapheresis with a replacement of human albumin as a colloidal solution. Complications did not occur during the treatment. Plasmapheresis reduced her triglyceride level by 54.1% (to 18.8 mmol/L), and the patient delivered a healthy female neonate at 40 weeks. In case of significantly increased values, plasmapheresis is a fast, effective and safe method for decreasing triglyceride level even in the third trimester.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok esettanulmány folyóiratcikk Hypertriglyceridemia pregnancy plasmapheresis
Megjelenés:	Vessel Plus. - 3 : 6 (2019), p. 1-6. -
További szerzők:	Kovács Beáta (1989-) (belgyógyász) Paragh György (1953-) (belgyógyász) Balla József (1959-) (belgyógyász, nephrológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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