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001-es BibID:BIBFORM006864
Első szerző:Mohás Márton
Cím:Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome / Mohas, M., Szigeti, N., Marko, L., Molnar, G. A., Cseh, J., Laczy, B., Tamasko, M., Balla, J., Kappelmayer, J., Wagner, L., Wagner, Z., Csiky, B., Nagy, J., Wittmann, I.
Dátum:2008
Megjegyzések:Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. METHODS: In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). RESULTS: Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0.001) and correlated with serum total protein (r = -0.549, p < 0.001), serum albumin (r = -0.596, p < 0.001), proteinuria (r = 0.456, p < 0.001) and serum total cholesterol (r = 0.523, p < 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p < 0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p < 0.001), serum albumin (r = -0.615, p < 0.001), proteinuria (r = 0.694, p < 0.001), and serum total cholesterol (r = 0.723, p < 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2. CONCLUSIONS: These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Biological Markers/blood
Cohort Studies
Cross-Sectional Studies
Enzyme Activation/physiology
Female
Humans
Male
Middle Aged
Retrospective Studies
Megjelenés:Kidney and Blood Pressure Research. - 31 : 1 (2008), p. 47-54. -
További szerzők:Szigeti Nóra Markó Lajos Molnár Gergő Attila Cseh Judit Laczy Boglárka Tamaskó Mónika Balla József (1959-) (belgyógyász, nephrológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Wagner László Wagner Zoltán Csiky Botond Nagy Judit (kutató) Wittmann István
Internet cím:elektronikus változat
elektronikus változat
DOI
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2.

001-es BibID:BIBFORM040399
Első szerző:Vas T.
Cím:Oxidative stress and non-enzymatic glycation in IgA nephropathy / Vas T., Wagner Z., Jenei V., Varga Z., Kovács T., Wittmann I., Schinzel R., Balla G., Balla J., Heidland A., Nagy J.
Dátum:2005
ISSN:0301-0430
Megjegyzések:AIM: Approximately 20-50% of IgA nephropathy patients develop end-stage renal disease. We have previously found enhanced oxidative stress and decreased antioxidant capacity in red blood cells of IgA nephropathy patients. In this study we assess oxidative stress, non-enzymatic glycation, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content in these patients. PATIENTS AND METHODS: Non-enzymatic glycation and oxidative stress were assessed in 88 IgA nephropathy patients by measuring advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid reactive substances, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content. RESULTS: Advanced glycation end products (2659 +/- 958 a.u.) and Nepsilon-carboxymethyl-lysine (563 +/- 215 ng/ml) were significantly higher in IgA nephropathy patients with decreased renal function compared to those with normal renal function (p < 0.002) or controls (p < 0.001). Thiobarbituric acid-reactive substances in plasma and associated with low-density lipoprotein were significantly elevated and oxidative resistance of low-density lipoprotein was significantly reduced in all groups of IgA nephropathy patients. There was no significant difference in circulating fluorescent advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid-reactive substances levels, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content between patients with normal vs. impaired glucose metabolism. Low alpha-tocopherol content of low-density lipoprotein was accompanied with decreased oxidative resistance, depletion in polyunsaturated fatty acids, elevated saturated fatty acids and thiobarbituric acid-reactive substances within low-density lipoprotein suggesting enhanced lipid peroxidation. CONCLUSIONS: Decreased oxidative resistance of low-density lipoprotein and enhanced oxidative stress are common features in IgA nephropathy, while increased non-enzymatic glycation occurs as renal function declines.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Nephrology. - 64 : 5 (2005), p. 343-351. -
További szerzők:Wagner Zoltán Jeney Viktória (1971-) (vegyész, kémia tanár) Varga Z. Kovács T. Wittmann István Schinzel, R. Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Balla József (1959-) (belgyógyász, nephrológus) Heidland, A. Nagy J. (orvos)
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