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001-es BibID:	BIBFORM035236
Első szerző:	Zarjou, Abolfazl (kutató orvos)
Cím:	Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1 / Zarjou Abolfazl, Kim Junghyun, Traylor Amie M., Sanders Paul W., Balla József, Agarwal Anupam, Curtis Lisa M.
Dátum:	2011
ISSN:	0363-6127
Megjegyzések:	Multipotent mesenchymal stem cells (MSC) have become a popular and promising therapeutic approach in many clinical conditions. MSC are beneficial in animal models of acute kidney injury (AKI), by mediating differentiation-independent paracrine properties, and have prompted ongoing clinical trials to evaluate the safety and efficacy of MSC. Heme oxygenase-1 (HO-1) is induced in response to stress including AKI and has important anti-apoptotic, anti-inflammatory, and proangiogenic properties in these settings. We therefore examined whether HO-1 plays a role in the beneficial effects of MSC in AKI. We isolated MSC from bone marrow of age-matched HO-1+/+ and HO-1-/- mice. Our studies indicate that while differentiation of MSC into osteo- and adipocytic lineages did not differ between cells isolated from HO-1+/+ and HO-1-/- mice, MSC from HO-1-/- mice had significantly lower angiogenic potential. Moreover, HO-1-/- MSC demonstrated reduced expression and secretion of several important growth and proangiogenic factors (stromal cell-derived factor-1, vascular endothelial growth factor-A, and hepatocyte growth factor) compared with MSC derived from HO-1+/+ mice. In addition, conditioned medium of HO-1+/+ MSC rescued functional and morphological changes associated with cisplatin-induced AKI, while the HO-1-/--conditioned medium was ineffectual. Our studies indicate that HO-1 plays an important role in MSC-mediated protection. The results expand understanding of the renoprotective effects of MSC and may provide novel strategies to better utilize MSC in various disease models.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	American Journal of Physiology-Renal Physiology. - 300 : 1 (2011), p. F254-F262. -
További szerzők:	Kim, Junghyun Traylor, Amie M. Sanders, Paul W. Balla József (1959-) (belgyógyász, nephrológus) Agarwal, Anupam Curtis, Lisa M.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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