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001-es BibID:	BIBFORM110272
035-os BibID:	(cikkazonosító)1477 (WoS)000930056200001 (Scopus)85147892443
Első szerző:	Bíró Linda (vegyész)
Cím:	Interaction between [(eta(6)-p-cym)M(H2O)(3)](2+) (M-II = Ru, Os) or [(eta(5)-Cp*)M(H2O)(3)](2+) (M-III = Rh, Ir) and Phosphonate Derivatives of Iminodiacetic Acid: A Solution Equilibrium and DFT Study / Linda Bíró, Botond Tóth, Norbert Lihi, Etelka Farkas, Péter Buglyó
Dátum:	2023
ISSN:	1420-3049
Megjegyzések:	The pH-dependent binding strengths and modes of the organometallic [(eta(6)-p-cym)M(H2O)(3)](2+) (M-II = Ru, Os; p-cym = 1-methyl-4-isopropylbenzene) or [(eta(5)-Cp)M(H2O)(3)](2+) (M-III = Rh, Ir; Cp = pentamethylcyclopentadienyl anion) cations towards iminodiacetic acid (H(2)Ida) and its biorelevant mono- and diphosphonate derivatives N-(phosphonomethyl)-glycine (H(3)IdaP) and iminodi(methylphosphonic acid) (H(4)Ida2P) was studied in an aqueous solution. The results showed that all three of the ligands form 1:1 complexes via the tridentate (O,N,O) donor set, for which the binding mode was further corroborated by the DFT method. Although with IdaP(3-) and Ida2P(4-) in mono- and bis-protonated species, where H+ might also be located at the non-coordinating N atom, the theoretical calculations revealed the protonation of the phosphonate group(s) and the tridentate coordination of the phosphonate ligands. The replacement of one carboxylate in Ida(2-) by a phosphonate group (IdaP(3-)) resulted in a significant increase in the stability of the metal complexes; however, this increase vanished with Ida2P(4-), which was most likely due to some steric hindrance upon the coordination of the second large phosphonate group to form (5 + 5) joined chelates. In the phosphonate-containing systems, the neutral 1:1 complexes are the major species at pH 7.4 in the millimolar concentration range that is supported by both NMR and ESI-TOF-MS.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk IDA-based phosphonates organoruthenium organorhodium solution equilibrium complex
Megjelenés:	Molecules. - 28 : 3 (2023), p. 1-17-. -
További szerzők:	Tóth Botond Lihi Norbert (1990-) (vegyész) Farkas Etelka (1948-) (vegyész) Buglyó Péter (1965-) (vegyész)
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001-es BibID:	BIBFORM100515
035-os BibID:	(cikkazonosító)669 (WoS)000760234200001 (Scopus)85123114917
Első szerző:	Bíró Linda (vegyész)
Cím:	Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution / Bíró Linda, Buglyó Péter, Farkas Etelka
Dátum:	2022
ISSN:	1420-3049
Megjegyzések:	Complexes that incorporate both ligand(s) and metal(s) exhibiting cytotoxic activity can especially be interesting to develop multifunctional drug molecules with desired activities. In this review, the limited number of solution results collected in our laboratory on the complexes of Pd(II) and two other platinum group metals-the half-sandwich type, [(6-p-cym)Ru(H2O)3]2+, and [(5-Cp*)Rh(H2O)3]2+-with hydroxamic acid derivatives of three amino acids, two imidazole analogues, and four small peptides are summarized and evaluated. Unlike the limited number of coordination sites of these metal ions (four and three for Pd(II) and the organometallic cations, respectively), the ligands discussed here offer a relatively high number of donor atoms as well as variation in their position within the ligands, resulting in a large versatility of the likely coordination modes. The review, besides presenting the solution equilibrium results, also discusses the main factors, such as (N,N) versus (O,O) chelate; size of chelate; amino-N versus imidazole-N; primary versus secondary hydroxamic function; differences between hydrolytic ability of the metal ions studied; and hydrolysis of the coordinated peptide hydroxamic acids in their Pd(II) complexes, which all determine the coordination modes present in the complexes formed in measurable concentrations in these systems. The options for the quantitative evaluation of metal binding effectivity and selectivity of the various ligands and the comparison with each other by using solution equilibrium data are also discussed.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Molecules. - 27 : 3 (2022), p. 1-27. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Farkas Etelka (1948-) (vegyész)
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001-es BibID:	BIBFORM099415
035-os BibID:	(cikkazonosító)3586 (WoS)000666566100001 (Scopus)85108329799
Első szerző:	Nagy Sándor (vegyész)
Cím:	Donor Atom Preference of Organoruthenium and Organorhodium Cations on the Interaction with Novel Ambidentate (N,N) and (O,O) Chelating Ligands in Aqueous Solution / Nagy Sándor, Ozsváth András, Bényei Attila Cs., Farkas Etelka, Buglyó Péter
Dátum:	2021
ISSN:	1420-3049
Megjegyzések:	Two novel, pyridinone-based chelating ligands containing separated (O,O) and (Namino,Nhet) chelating sets (Namino = secondary amine; Nhet = pyrrole N for H(L3) (1-(3-(((1H-pyrrole-2-yl)methyl)-amino)propyl)-3-hydroxy-2-methylpyridin-4(1H)-one) or pyridine N for H(L5) (3-hydroxy-2-methyl-1-(3-((pyridin-2-ylmethyl)amino)propyl)pyridin-4(1H)-one)) were synthesized via reduction of the appropriate imines. Their proton dissociation processes were explored, and the molecular structures of two synthons were assessed by X-ray crystallography. These ambidentate chelating ligands are intended to develop Co(III)/PGM (PGM = platinum group metal) heterobimetallic multitargeted complexes with anticancer potential. To explore their metal ion binding ability, the interaction with Pd(II), [(?6-p-cym)Ru]2+ and [(?5-Cp)Rh]2+ (p-cym = 1-methyl-4-isopropylbenzene, Cp = pentamethyl-cyclopentadienyl anion) cations was studied in aqueous solution with the combined use of pH-potentiometry, NMR and HR ESI-MS. In general, organorhodium was found to form more labile complexes over ruthenium, while complexation of the (N,N) chelating set was slower than the processes of the pyridinone unit with (O,O) coordination. Formation of the organoruthenium complexes starts at lower pH (higher thermodynamic stabilities of the corresponding complexes) than for [(?5-Cp)Rh]2+ but, due to the higher affinity of [?6-p-cym)Ru]2+ towards hydrolysis, the complexed ligands are capable of competing with hydroxide ion in a lesser extent than for the rhodium systems. As a result, under biologically relevant conditions, the rhodium binding effectivity of the ligands becomes comparable or even slightly higher than their effectivity towards ruthenium. Our results indicate that H(L3) is a less efficient (N,N) chelator for these metal ions than H(L5). Similarly, due to the relative effectivity of the (O,O) and (N,N) chelates at a 1:1 metal-ion-to-ligand ratio, H(L5) coordinates in a (N,N) manner to both cations in the whole pH range studied while, for H(L3), the complexation starts with (O,O) coordination. At a 2:1 metal-ion-to-ligand ratio, H(L3) cannot hinder the intensive hydrolysis of the second metal ion, although a small amount of 2:1 complex with [(?5-Cp)Rh]2+ can also be detected.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ruténium ródium komplex piridinon maltol
Megjelenés:	Molecules. - 26 : 12 (2021), p. 1-23. -
További szerzők:	Ozsváth András (1992-) (vegyész) Bényei Attila (1962-) (vegyész) Farkas Etelka (1948-) (vegyész) Buglyó Péter (1965-) (vegyész)
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001-es BibID:	BIBFORM087177
035-os BibID:	(cikkazonosító)3941 (WoS)000498055500130 (Scopus)85074330646
Első szerző:	Ozsváth András (vegyész)
Cím:	Trends and Exceptions in the Interaction of Hydroxamic Acid Derivatives of Common Di- and Tripeptides with Some 3d and 4d Metal Ions in Aqueous Solution / András Ozsváth, Linda Bíró, Eszter Márta Nagy, Péter Buglyó, Daniele Sanna, Etelka Farkas
Dátum:	2019
ISSN:	1420-3049
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Molecules. - 24 : 21 (2019), p. 1-25. -
További szerzők:	Bíró Linda (1985-) (vegyész) Nagy Eszter Márta (1976-) (vegyész) Buglyó Péter (1965-) (vegyész) Sanna, Daniele (1956-) (vegyész) Farkas Etelka (1948-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP OTKA K112317 OTKA
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